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3FDQ
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BU of 3fdq by Molmil
Recognition of AT-rich DNA binding sites by the MogR Repressor
分子名称: 5'-D(*AP*TP*TP*TP*TP*TP*TP*AP*AP*AP*AP*AP*AP*AP*T)-3', 5'-D(*TP*AP*TP*TP*TP*TP*TP*TP*TP*AP*AP*AP*AP*AP*A)-3', Motility gene repressor mogR
著者Shen, A, Higgins, D.E, Panne, D.
登録日2008-11-26
公開日2009-06-02
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Recognition of AT-Rich DNA Binding Sites by the MogR Repressor.
Structure, 17, 2009
3GCD
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BU of 3gcd by Molmil
Structure of the V. cholerae RTX cysteine protease domain in complex with an aza-Leucine peptide inhibitor
分子名称: INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION, ...
著者Lupardus, P.J, Garcia, K.C, Shen, A, Bogyo, M.
登録日2009-02-21
公開日2009-05-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin.
Nat.Chem.Biol., 5, 2009
3EEB
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BU of 3eeb by Molmil
Structure of the V. cholerae RTX cysteine protease domain
分子名称: INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION
著者Lupardus, P.J, Shen, A, Bogyo, M, Garcia, K.C.
登録日2008-09-04
公開日2008-10-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain
Science, 322, 2008
6NST
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BU of 6nst by Molmil
Crystal structure of branched chain amino acid aminotransferase from Pseudomonas aeruginosa
分子名称: Branched-chain-amino-acid aminotransferase, SULFATE ION
著者Chang, C, Skarina, T, Savshenko, A, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2019-01-25
公開日2019-02-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.136 Å)
主引用文献Crystal structure of branched chain amino acid aminotransferase from Pseudomonas aeruginosa
To Be Published
4S3G
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BU of 4s3g by Molmil
Structure of the F249X mutant of Phosphatidylinositol-specific phospholipase C from Staphylococcus aureus
分子名称: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ACETATE ION
著者He, T, Gershenson, A, Eyles, S.J, Gao, J, Roberts, M.F.
登録日2015-01-26
公開日2015-07-01
最終更新日2015-08-19
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Fluorinated Aromatic Amino Acids Distinguish Cation-pi Interactions from Membrane Insertion.
J.Biol.Chem., 290, 2015
4RV3
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BU of 4rv3 by Molmil
Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus
分子名称: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ACETATE ION
著者He, T, Gershenson, A, Eyles, S.J, Gao, J, Roberts, M.F.
登録日2014-11-24
公開日2015-07-01
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Fluorinated Aromatic Amino Acids Distinguish Cation-pi Interactions from Membrane Insertion.
J.Biol.Chem., 290, 2015
1C7J
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BU of 1c7j by Molmil
PNB ESTERASE 56C8
分子名称: POTASSIUM ION, PROTEIN (PARA-NITROBENZYL ESTERASE), SULFATE ION
著者Spiller, B, Gershenson, A, Arnold, F, Stevens, R.C.
登録日2000-02-21
公開日2000-03-29
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A structural view of evolutionary divergence.
Proc.Natl.Acad.Sci.USA, 96, 1999
1C7I
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BU of 1c7i by Molmil
THERMOPHYLIC PNB ESTERASE
分子名称: CALCIUM ION, PROTEIN (PARA-NITROBENZYL ESTERASE)
著者Spiller, B, Gershenson, A, Arnold, F, Stevens, R.
登録日2000-02-21
公開日2000-03-29
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A structural view of evolutionary divergence.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QE3
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BU of 1qe3 by Molmil
PNB ESTERASE
分子名称: PARA-NITROBENZYL ESTERASE, SULFATE ION, ZINC ION
著者Spiller, B, Gershenson, A, Arnold, F, Stevens, R.
登録日1999-07-12
公開日1999-07-21
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献A structural view of evolutionary divergence.
Proc.Natl.Acad.Sci.USA, 96, 1999
4F2U
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BU of 4f2u by Molmil
Structure of the N254Y/H258Y double mutant of the Phosphatidylinositol-Specific Phospholipase C from S.aureus
分子名称: 1-phosphatidylinositol phosphodiesterase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION
著者Cheng, J, Goldstein, R, Stec, B, Gershenson, A, Roberts, M.F.
登録日2012-05-08
公開日2012-12-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity.
J.Biol.Chem., 287, 2012
4F2T
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BU of 4f2t by Molmil
Modulation of S.aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding.
分子名称: 1-phosphatidylinositol phosphodiesterase, ACETATE ION
著者Cheng, J, Goldstein, R, Stec, B, Gershenson, A, Roberts, M.F.
登録日2012-05-08
公開日2012-12-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity.
J.Biol.Chem., 287, 2012
4F2B
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BU of 4f2b by Molmil
Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding
分子名称: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase
著者Cheng, J, Goldstein, R, Stec, B, Gershenson, A, Roberts, M.F.
登録日2012-05-07
公開日2012-12-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity.
J.Biol.Chem., 287, 2012
4I9J
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BU of 4i9j by Molmil
Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC
分子名称: (4S,7R)-7-(heptanoyloxy)-4-hydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphahexadecan-1-aminium 4-oxide, 1-phosphatidylinositol phosphodiesterase, ACETATE ION
著者Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F.
登録日2012-12-05
公開日2013-04-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
4I8Y
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BU of 4i8y by Molmil
Structure of the unliganded N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus
分子名称: 1-phosphatidylinositol phosphodiesterase, ACETATE ION, CHLORIDE ION
著者Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F.
登録日2012-12-04
公開日2013-04-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
4I90
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BU of 4i90 by Molmil
Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to choline
分子名称: 1-phosphatidylinositol phosphodiesterase, ACETATE ION, CHLORIDE ION, ...
著者Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F.
登録日2012-12-04
公開日2013-04-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
4I9M
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Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from Staphylococcus aureus bound to HEPES
分子名称: 1-phosphatidylinositol phosphodiesterase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION
著者Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F.
登録日2012-12-05
公開日2013-04-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
4I9T
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BU of 4i9t by Molmil
Structure of the H258Y mutant of the phosphatidylinositol-specific phospholipase C from Staphylococcus aureus
分子名称: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, SULFATE ION, ...
著者Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F.
登録日2012-12-05
公開日2013-04-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
3PEE
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BU of 3pee by Molmil
Structure of the C. difficile TcdB cysteine protease domain
分子名称: CALCIUM ION, INOSITOL HEXAKISPHOSPHATE, Toxin B
著者Lupardus, P.J, Garcia, K.C.
登録日2010-10-26
公開日2011-02-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins.
Nat.Struct.Mol.Biol., 18, 2011
4LWE
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BU of 4lwe by Molmil
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ2
分子名称: Heat shock protein HSP 90-alpha, N-[3-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetamide
著者Li, J, Shi, F, Xiong, B, He, J.
登録日2013-07-27
公開日2014-07-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
4LWI
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BU of 4lwi by Molmil
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6
分子名称: Heat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl}cyclopropanecarboxamide
著者Li, J, Shi, F, Xiong, B, He, J.
登録日2013-07-27
公開日2014-07-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
4LWF
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Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ3
分子名称: 4-(5-amino-1,2-oxazol-3-yl)-6-(propan-2-yl)benzene-1,3-diol, Heat shock protein HSP 90-alpha
著者Li, J, Shi, F, Xiong, B, He, J.
登録日2013-07-27
公開日2014-07-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
4LWG
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BU of 4lwg by Molmil
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ4
分子名称: 1-(5-chloro-2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone, Heat shock protein HSP 90-alpha
著者Li, J, Shi, F, Xiong, B, He, J.
登録日2013-07-27
公開日2014-07-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.599 Å)
主引用文献Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
4LWH
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Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5
分子名称: Heat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazol-5-yl}cyclopropanecarboxamide
著者Li, J, Shi, F, Xiong, B, He, J.
登録日2013-07-27
公開日2014-07-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
1Y12
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Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa
分子名称: hypothetical protein PA0085
著者Cuff, M.E, Zhou, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
登録日2004-11-16
公開日2005-01-25
最終更新日2020-03-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.
Science, 312, 2006
4L8Z
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Crystal structure of Human Hsp90 with RL1
分子名称: Heat shock protein HSP 90-alpha, [5-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
著者Li, J, Ren, J, Yang, M, Xiong, B, He, J.
登録日2013-06-18
公開日2014-06-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.703 Å)
主引用文献Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
Bioorg.Med.Chem.Lett., 24, 2014

 

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