3FWE
 
 | | Crystal Structure of the Apo D138L CAP mutant | | 分子名称: | Catabolite gene activator, PROLINE | | 著者 | Sharma, H, Wang, J, Kong, J, Yu, S, Steitz, T. | | 登録日 | 2009-01-17 | | 公開日 | 2009-09-08 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding
Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
4ECK
 | | Crystal Structure of the Toxoplasma gondii TS-DHFR | | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | | 著者 | Sharma, H, Anderson, K.S. | | 登録日 | 2012-03-26 | | 公開日 | 2013-10-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.516 Å) | | 主引用文献 | First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase-Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling.
Biochemistry, 52, 2013
|
|
4EIL
 | | Crystal Structure of the loop truncated Toxoplasma gondii TS-DHFR | | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | | 著者 | Sharma, H. | | 登録日 | 2012-04-05 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1971 Å) | | 主引用文献 | First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase-Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling.
Biochemistry, 52, 2013
|
|
9BK2
 | | Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (S-enantiomer, monoclinic P form) | | 分子名称: | (2S)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid, DIMETHYL SULFOXIDE, L-lactate dehydrogenase A chain, ... | | 著者 | Lovell, S, Cooper, A, Battaile, K.P, Sharma, H, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2024-04-26 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer.
Eur.J.Med.Chem., 275, 2024
|
|
9BK3
 | | Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (R-enantiomer, orthorhombic P form) | | 分子名称: | (2R)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid, CHLORIDE ION, L-lactate dehydrogenase A chain, ... | | 著者 | Lovell, S, Cooper, A, Battaile, K.P, Sharma, H. | | 登録日 | 2024-04-26 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer.
Eur.J.Med.Chem., 275, 2024
|
|
3HIF
 | | The crystal structure of apo wild type CAP at 3.6 A resolution. | | 分子名称: | Catabolite gene activator | | 著者 | Steitz, T.A, Sharma, H, Wang, J, Kong, J, Yu, S. | | 登録日 | 2009-05-19 | | 公開日 | 2009-09-08 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.59 Å) | | 主引用文献 | Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding.
Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
4KYA
 | | Crystal structure of non-classical TS inhibitor 3 in complex with Toxoplasma gondii TS-DHFR | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-Amino-5-(1-naphthylsulfanyl)-3,9-dihydro-4H-pyrimido[4,5-b]indol-4-one, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | | 著者 | Sharma, H, Anderson, K.S. | | 登録日 | 2013-05-28 | | 公開日 | 2014-08-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.263 Å) | | 主引用文献 | Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.
ACS Med Chem Lett, 4, 2013
|
|
4KY4
 | | Crystal structure of non-classical TS inhibitor 2 in complex with Toxoplasma gondii TS-DHFR | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-amino-5-(phenylsulfanyl)-3,9-dihydro-4H-pyrimido[4,5-b]indol-4-one, Aminopterin, ... | | 著者 | Sharma, H, Anderson, K.S. | | 登録日 | 2013-05-28 | | 公開日 | 2014-08-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.
ACS Med Chem Lett, 4, 2013
|
|
2GTL
 | | Lumbricus Erythrocruorin at 3.5A resolution | | 分子名称: | CALCIUM ION, CARBON MONOXIDE, Extracellular globin 2, ... | | 著者 | Royer Jr, W.E, Sharma, H, Strand, K, Knapp, J.E, Bhyravbhatla, B. | | 登録日 | 2006-04-28 | | 公開日 | 2006-07-18 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Lumbricus erythrocruorin at 3.5 a resolution: architecture of a megadalton respiratory complex.
Structure, 14, 2006
|
|
6ZU5
 | | Structure of the Paranosema locustae ribosome in complex with Lso2 | | 分子名称: | 18S rRNA, 25S rRNA, 5S rRNA, ... | | 著者 | Ehrenbolger, K, Jespersen, N, Sharma, H, Sokolova, Y.Y, Tokarev, Y.S, Vossbrinck, C.R, Barandun, J. | | 登録日 | 2020-07-21 | | 公開日 | 2020-11-04 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Differences in structure and hibernation mechanism highlight diversification of the microsporidian ribosome.
Plos Biol., 18, 2020
|
|
7MZV
 | | Structure of yeast pseudouridine synthase 7 (PUS7) | | 分子名称: | Multisubstrate pseudouridine synthase 7, SULFATE ION | | 著者 | Purchal, M, Koutmos, M. | | 登録日 | 2021-05-24 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Pseudouridine synthase 7 is an opportunistic enzyme that binds and modifies substrates with diverse sequences and structures.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
