4ECK

Crystal Structure of the Toxoplasma gondii TS-DHFR

Summary for 4ECK

Entry DOI	10.2210/pdb4eck/pdb
Descriptor	Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (5 entities in total)
Functional Keywords	bifunctional, transferase, oxidoreductase
Biological source	Toxoplasma gondii
Total number of polymer chains	2
Total formula weight	141630.25
Authors	Sharma, H.,Anderson, K.S. (deposition date: 2012-03-26, release date: 2013-10-02, Last modification date: 2023-09-13)
Primary citation	Sharma, H.,Landau, M.J.,Vargo, M.A.,Spasov, K.A.,Anderson, K.S. First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase-Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling. Biochemistry, 52:7305-7317, 2013 Cited by PubMed: 24053355 DOI: 10.1021/bi400576t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.516 Å)

Structure validation