1YDK
 
 | | Crystal structure of the I219A mutant of human glutathione transferase A1-1 with S-hexylglutathione | | 分子名称: | Glutathione S-transferase A1, S-HEXYLGLUTATHIONE | | 著者 | Kuhnert, D.C, Sayed, Y, Mosebi, S, Sayed, M, Sewell, T, Dirr, H.W. | | 登録日 | 2004-12-24 | | 公開日 | 2005-06-07 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Tertiary Interactions Stabilise the C-terminal Region of Human Glutathione Transferase A1-1: a Crystallographic and Calorimetric Study.
J.Mol.Biol., 349, 2005
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2R3X
 | | Crystal structure of an R15L hGSTA1-1 mutant complexed with S-hexyl-glutathione | | 分子名称: | Glutathione S-transferase A1, S-HEXYLGLUTATHIONE | | 著者 | Burke, J.P.W.G, Kinsley, N, Sayed, M, Sewell, T, Dirr, H.W. | | 登録日 | 2007-08-30 | | 公開日 | 2007-12-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1.
Biophys.Chem., 146, 2010
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2R6K
 | | Crystal structure of an I71V hGSTA1-1 mutant in complex with S-hexylglutathione | | 分子名称: | Glutathione S-transferase A1, S-HEXYLGLUTATHIONE | | 著者 | Dirr, H.W, Fisher, L, Burke, J.P.W.G, Sayed, M, Sewell, T. | | 登録日 | 2007-09-06 | | 公開日 | 2008-08-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function.
Acta Crystallogr.,Sect.F, 66, 2010
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9BLG
 | | Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with PF-07284892 | | 分子名称: | (1S)-1'-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-1,2,4-triazin-3-yl}-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine, Tyrosine-protein phosphatase non-receptor type 11 | | 著者 | Bester, S.M, Wu, W.-I, Mou, T.-C. | | 登録日 | 2024-04-30 | | 公開日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy.
Cancer Discov, 13, 2023
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