3LOK
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![BU of 3lok by Molmil](/molmil-images/mine/3lok) | |
2QLQ
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![BU of 2qlq by Molmil](/molmil-images/mine/2qlq) | Crystal structure of SRC kinase domain with covalent inhibitor RL3 | 分子名称: | (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide, Proto-oncogene tyrosine-protein kinase Src | 著者 | Michalczyk, A, Rode, H.B, Gruetter, C, Rauh, D. | 登録日 | 2007-07-13 | 公開日 | 2008-03-11 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg.Med.Chem., 16, 2008
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2QQ7
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![BU of 2qq7 by Molmil](/molmil-images/mine/2qq7) | Crystal structure of drug resistant SRC kinase domain with irreversible inhibitor | 分子名称: | (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide, Proto-oncogene tyrosine-protein kinase Src | 著者 | Michalczyk, A, Rode, H.B, Gruetter, C, Rauh, D. | 登録日 | 2007-07-26 | 公開日 | 2008-03-11 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg.Med.Chem., 16, 2008
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2QI8
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![BU of 2qi8 by Molmil](/molmil-images/mine/2qi8) | Crystal structure of drug resistant SRC kinase domain | 分子名称: | GLYCEROL, Proto-oncogene tyrosine-protein kinase Src | 著者 | Michalczyk, A, Rode, H.B, Gruetter, C, Rauh, D. | 登録日 | 2007-07-03 | 公開日 | 2008-03-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg.Med.Chem., 16, 2008
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3F3T
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![BU of 3f3t by Molmil](/molmil-images/mine/3f3t) | Kinase domain of cSrc in complex with inhibitor RL38 (Type III) | 分子名称: | 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea, Proto-oncogene tyrosine-protein kinase Src | 著者 | Gruetter, C, Klueter, S, Getlik, M, Rauh, D. | 登録日 | 2008-10-31 | 公開日 | 2009-03-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A new screening assay for allosteric inhibitors of cSrc Nat.Chem.Biol., 5, 2009
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3G5D
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![BU of 3g5d by Molmil](/molmil-images/mine/3g5d) | Kinase domain of cSrc in complex with Dasatinib | 分子名称: | GLYCEROL, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Proto-oncogene tyrosine-protein kinase Src | 著者 | Grutter, C, Kluter, S, Rauh, D. | 登録日 | 2009-02-05 | 公開日 | 2009-06-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc J.Med.Chem., 52, 2009
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3F3U
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![BU of 3f3u by Molmil](/molmil-images/mine/3f3u) | Kinase domain of cSrc in complex with inhibitor RL37 (Type III) | 分子名称: | 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea, Proto-oncogene tyrosine-protein kinase Src | 著者 | Gruetter, C, Klueter, S, Getlik, M, Rauh, D. | 登録日 | 2008-10-31 | 公開日 | 2009-03-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A new screening assay for allosteric inhibitors of cSrc Nat.Chem.Biol., 5, 2009
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3F3V
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![BU of 3f3v by Molmil](/molmil-images/mine/3f3v) | Kinase domain of cSrc in complex with inhibitor RL45 (Type II) | 分子名称: | 1-{4-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea, Proto-oncogene tyrosine-protein kinase Src | 著者 | Grutter, C, Kluter, S, Getlik, M, Rauh, D. | 登録日 | 2008-10-31 | 公開日 | 2009-06-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc J.Med.Chem., 52, 2009
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3F3W
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![BU of 3f3w by Molmil](/molmil-images/mine/3f3w) | Drug resistant cSrc kinase domain in complex with inhibitor RL45 (Type II) | 分子名称: | 1-{4-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea, Proto-oncogene tyrosine-protein kinase Src | 著者 | Grutter, C, Kluter, S, Getlik, M, Rauh, D. | 登録日 | 2008-10-31 | 公開日 | 2009-06-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc J.Med.Chem., 52, 2009
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