6X8N
| Crystal Structure of H49A ABLE mutant | 分子名称: | De novo designed ABLE protein | 著者 | Polizzi, N.F. | 登録日 | 2020-06-01 | 公開日 | 2020-08-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A defined structural unit enables de novo design of small-molecule-binding proteins. Science, 369, 2020
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6W6X
| Crystal Structure of ABLE Apo-protein | 分子名称: | ACETATE ION, De novo designed ABLE protein, SULFATE ION | 著者 | Polizzi, N.F. | 登録日 | 2020-03-18 | 公開日 | 2020-08-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.297 Å) | 主引用文献 | A defined structural unit enables de novo design of small-molecule-binding proteins. Science, 369, 2020
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6W70
| Crystal Structure of apixaban-bound ABLE | 分子名称: | 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDINE-3-CARBOXAMIDE, ACETATE ION, De novo designed ABLE, ... | 著者 | Polizzi, N.F. | 登録日 | 2020-03-18 | 公開日 | 2020-08-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.296 Å) | 主引用文献 | A defined structural unit enables de novo design of small-molecule-binding proteins. Science, 369, 2020
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5TGY
| NMR structure of holo-PS1 | 分子名称: | PS1, [5,10,15,20-tetrakis(trifluoromethyl)porphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]zinc | 著者 | Polizzi, N.F, Wu, Y. | 登録日 | 2016-09-28 | 公開日 | 2017-08-09 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | De novo design of a hyperstable non-natural protein-ligand complex with sub- angstrom accuracy. Nat Chem, 9, 2017
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5TGW
| NMR structure of apo-PS1 | 分子名称: | PS1 | 著者 | Polizzi, N.F, Wu, Y. | 登録日 | 2016-09-28 | 公開日 | 2017-08-09 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | De novo design of a hyperstable non-natural protein-ligand complex with sub- angstrom accuracy. Nat Chem, 9, 2017
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5UGK
| Zinc-Binding Structure of a Catalytic Amyloid from Solid-State NMR Spectroscopy | 分子名称: | ILE-HIS-VAL-HIS-LEU-GLN-ILE, ZINC ION | 著者 | Lee, M, Wang, T, Makhlynets, O.V, Wu, Y, Polizzi, N, Wu, H, Gosavi, P.M, Korendovych, I.V, DeGrado, W.F, Hong, M. | 登録日 | 2017-01-09 | 公開日 | 2017-05-31 | 最終更新日 | 2024-05-15 | 実験手法 | SOLID-STATE NMR | 主引用文献 | Zinc-binding structure of a catalytic amyloid from solid-state NMR. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7JH6
| De novo designed two-domain di-Zn(II) and porphyrin-binding protein | 分子名称: | NONAETHYLENE GLYCOL, Two-domain di-Zn(II) and porphyrin-binding protein, ZINC ION, ... | 著者 | Schmidt, N, Liu, L, DeGrado, W.F. | 登録日 | 2020-07-20 | 公開日 | 2020-12-09 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Allosteric cooperation in a de novo-designed two-domain protein. Proc.Natl.Acad.Sci.USA, 117, 2020
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8TNB
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8TNC
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8TN1
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8TN6
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8TND
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6BKL
| Influenza A M2 transmembrane domain bound to rimantadine | 分子名称: | (1S)-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-amine, Matrix protein 2, RIMANTADINE | 著者 | Thomaston, J.L, DeGrado, W.F. | 登録日 | 2017-11-08 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | 主引用文献 | Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140, 2018
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6BKK
| Influenza A M2 transmembrane domain bound to amantadine | 分子名称: | (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine, CHLORIDE ION, Matrix protein 2 | 著者 | Thomaston, J.L, DeGrado, W.F. | 登録日 | 2017-11-08 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | 主引用文献 | Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140, 2018
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6BOC
| Influenza A M2 transmembrane domain bound to rimantadine in the Inward(open) conformation | 分子名称: | (1S)-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-amine, CHLORIDE ION, Matrix protein 2, ... | 著者 | Thomaston, J.L, DeGrado, W.F. | 登録日 | 2017-11-19 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140, 2018
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6BMZ
| Influenza A M2 transmembrane domain bound to a spiroadamantane inhibitor | 分子名称: | (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, CHLORIDE ION, Matrix protein 2 | 著者 | Thomaston, J.L, DeGrado, W.F. | 登録日 | 2017-11-15 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.634 Å) | 主引用文献 | Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140, 2018
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