7JH6

De novo designed two-domain di-Zn(II) and porphyrin-binding protein

Summary for 7JH6

Entry DOI	10.2210/pdb7jh6/pdb
Descriptor	Two-domain di-Zn(II) and porphyrin-binding protein, ZINC ION, [5,10,15,20-tetrakis(trifluoromethyl)porphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]zinc, ... (5 entities in total)
Functional Keywords	metalloprotein, inter-domain coupling and cooperation, de novo protein design, allostery, synthetic porphyrin, de novo protein
Biological source	synthetic construct
Total number of polymer chains	4
Total formula weight	86931.44
Authors	Schmidt, N.,Liu, L.,DeGrado, W.F. (deposition date: 2020-07-20, release date: 2020-12-09, Last modification date: 2024-04-03)
Primary citation	Pirro, F.,Schmidt, N.,Lincoff, J.,Widel, Z.X.,Polizzi, N.F.,Liu, L.,Therien, M.J.,Grabe, M.,Chino, M.,Lombardi, A.,DeGrado, W.F. Allosteric cooperation in a de novo-designed two-domain protein. Proc.Natl.Acad.Sci.USA, 117:33246-33253, 2020 Cited by PubMed: 33318174 DOI: 10.1073/pnas.2017062117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation