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4AX4
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, H680A MUTANT
分子名称: GLYCEROL, PROLYL OLIGOPEPTIDASE
著者Szeltner, Z, Juhasz, T, Szamosi, I, Rea, D, Fulop, V, Modos, K, Juliano, L, Polgar, L.
登録日2012-06-08
公開日2012-09-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The Loops Facing the Active Site of Prolyl Oligopeptidase are Crucial Components in Substrate Gating and Specificity.
Biochim.Biophys.Acta, 1834, 2012
2QR5
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Aeropyrum pernix acylaminoacyl peptidase, H367A mutant
分子名称: Acylamino-acid-releasing enzyme
著者Harmat, V, Pallo, A, Kiss, A.L, Polgar, L.
登録日2007-07-27
公開日2008-05-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and kinetic contributions of the oxyanion binding site to the catalytic activity of acylaminoacyl peptidase
J.Struct.Biol., 162, 2008
4HXF
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Acylaminoacyl peptidase in complex with Z-Gly-Gly-Phe-chloromethyl ketone
分子名称: CHLORIDE ION, HEXANE-1,6-DIOL, MAGNESIUM ION, ...
著者Kiss-Szeman, A, Menyhard, D.K, Tichy-Racs, E, Hornung, B, Radi, K, Szeltner, Z, Domokos, K, Szamosi, I, Naray-Szabo, G, Polgar, L, Harmat, V.
登録日2012-11-09
公開日2013-05-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献A Self-compartmentalizing Hexamer Serine Protease from Pyrococcus Horikoshii: SUBSTRATE SELECTION ACHIEVED THROUGH MULTIMERIZATION.
J.Biol.Chem., 288, 2013
4HXE
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Pyrococcus horikoshii acylaminoacyl peptidase (uncomplexed)
分子名称: HEXANE-1,6-DIOL, MAGNESIUM ION, Putative uncharacterized protein PH0594
著者Tichy-Racs, E, Hornung, B, Radi, K, Menyhard, D.K, Kiss-Szeman, A, Szeltner, Z, Domokos, K, Szamosi, I, Naray-Szabo, G, Polgar, L, Harmat, V.
登録日2012-11-09
公開日2013-05-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献A Self-compartmentalizing Hexamer Serine Protease from Pyrococcus Horikoshii: SUBSTRATE SELECTION ACHIEVED THROUGH MULTIMERIZATION.
J.Biol.Chem., 288, 2013
4HXG
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Pyrococcus horikoshii acylaminoacyl peptidase (orthorhombic crystal form)
分子名称: CHLORIDE ION, HEXANE-1,6-DIOL, MAGNESIUM ION, ...
著者Kiss-Szeman, A, Menyhard, D.K, Tichy-Racs, E, Hornung, B, Radi, K, Szeltner, Z, Domokos, K, Szamosi, I, Naray-Szabo, G, Polgar, L, Harmat, V.
登録日2012-11-09
公開日2013-05-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A Self-compartmentalizing Hexamer Serine Protease from Pyrococcus Horikoshii: SUBSTRATE SELECTION ACHIEVED THROUGH MULTIMERIZATION.
J.Biol.Chem., 288, 2013
2HU7
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Binding of inhibitors by Acylaminoacyl peptidase
分子名称: ACETYL GROUP, Acylamino-acid-releasing enzyme, GLYCEROL, ...
著者Kiss, A.L, Hornung, B, Radi, K, Gengeliczki, Z, Sztaray, B, Harmat, V, Polgar, L.
登録日2006-07-26
公開日2007-05-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
J.Mol.Biol., 368, 2007
2HU8
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Binding of inhibitors by Acylaminoacyl peptidase
分子名称: 2-AMINOBENZOIC ACID, Acylamino-acid-releasing enzyme, GLYCINE, ...
著者Kiss, A.L, Hornung, B, Radi, K, Gengeliczki, Z, Sztaray, B, Harmat, V, Polgar, L.
登録日2006-07-26
公開日2007-05-15
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
J.Mol.Biol., 368, 2007
2HU5
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Binding of inhibitors by Acylaminoacyl-peptidase
分子名称: Acylamino-acid-releasing enzyme, GLYCEROL, GLYCINE, ...
著者Kiss, A.L, Hornung, B, Radi, K, Gengeliczki, Z, Sztaray, B, Harmat, V, Polgar, L.
登録日2006-07-26
公開日2007-05-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
J.Mol.Biol., 368, 2007
3O4J
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Structure and Catalysis of Acylaminoacyl Peptidase
分子名称: Acylamino-acid-releasing enzyme, CHLORIDE ION, GLYCEROL, ...
著者Harmat, V, Domokos, K, Menyhard, D.K, Pallo, A, Szeltner, Z, Szamosi, I, Beke-Somfai, T, Naray-Szabo, G, Polgar, L.
登録日2010-07-27
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and Catalysis of Acylaminoacyl Peptidase: CLOSED AND OPEN SUBUNITS OF A DIMER OLIGOPEPTIDASE.
J.Biol.Chem., 286, 2011
3O4I
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Structure and Catalysis of Acylaminoacyl Peptidase
分子名称: Acylamino-acid-releasing enzyme, CHLORIDE ION, GLYCEROL
著者Harmat, V, Domokos, K, Menyhard, D.K, Pallo, A, Szeltner, Z, Szamosi, I, Beke-Somfai, T, Naray-Szabo, G, Polgar, L.
登録日2010-07-27
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure and Catalysis of Acylaminoacyl Peptidase: CLOSED AND OPEN SUBUNITS OF A DIMER OLIGOPEPTIDASE.
J.Biol.Chem., 286, 2011
3O4H
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Structure and Catalysis of Acylaminoacyl Peptidase
分子名称: Acylamino-acid-releasing enzyme, GLYCEROL, SODIUM ION
著者Harmat, V, Domokos, K, Menyhard, D.K, Pallo, A, Szeltner, Z, Szamosi, I, Beke-Somfai, T, Naray-Szabo, G, Polgar, L.
登録日2010-07-27
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Structure and Catalysis of Acylaminoacyl Peptidase: CLOSED AND OPEN SUBUNITS OF A DIMER OLIGOPEPTIDASE.
J.Biol.Chem., 286, 2011
3O4G
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Structure and Catalysis of Acylaminoacyl Peptidase
分子名称: Acylamino-acid-releasing enzyme, GLYCEROL
著者Harmat, V, Domokos, K, Menyhard, D.K, Pallo, A, Szeltner, Z, Szamosi, I, Beke-Somfai, T, Naray-Szabo, G, Polgar, L.
登録日2010-07-27
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and Catalysis of Acylaminoacyl Peptidase: CLOSED AND OPEN SUBUNITS OF A DIMER OLIGOPEPTIDASE.
J.Biol.Chem., 286, 2011
1UOP
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, S554A MUTANT WITH BOUND PEPTIDE LIGAND GLY-PHE-GLU-PRO
分子名称: GLYCEROL, PEPTIDE LIGAND GLY-PHE-GLU-PRO, PROLYL ENDOPEPTIDASE
著者Rea, D, Fulop, V.
登録日2003-09-22
公開日2003-10-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Electrostatic Environment at the Active Site of Prolyl Oligopeptidase is Highly Influential During Substrate Binding
J.Biol.Chem., 278, 2003
1VZ2
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, Y73C/V427C/C255T MUTANT
分子名称: GLYCEROL, PROLYL ENDOPEPTIDASE
著者Rea, D, Fulop, V.
登録日2004-05-14
公開日2004-07-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Concerted Structural Changes in the Peptidase and the Propeller Domains of Prolyl Oligopeptidase are Required for Substrate Binding
J.Mol.Biol., 340, 2004
1VZ3
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, T597C MUTANT
分子名称: GLYCEROL, PROLYL ENDOPEPTIDASE
著者Rea, D, Fulop, V.
登録日2004-05-14
公開日2004-07-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Concerted Structural Changes in the Peptidase and the Propeller Domains of Prolyl Oligopeptidase are Required for Substrate Binding
J.Mol.Biol., 340, 2004
1UOO
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Prolyl oligopeptidase from porcine brain, S554A mutant with bound peptide ligand GLY-PHE-ARG-PRO
分子名称: GLYCEROL, PEPTIDE LIGAND GLY-PHE-ARG-PRO, PROLYL ENDOPEPTIDASE
著者Rea, D, Fulop, V.
登録日2003-09-22
公開日2003-10-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Electrostatic Environment at the Active Site of Prolyl Oligopeptidase is Highly Influential During Substrate Binding
J.Biol.Chem., 278, 2003
1O6G
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, D641N MUTANT WITH BOUND PEPTIDE LIGAND SUC-GLY-PRO
分子名称: GLYCINE, PROLINE, Prolyl endopeptidase, ...
著者Rea, D, Fulop, V.
登録日2002-09-15
公開日2002-11-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase.
J. Biol. Chem., 277, 2002
1O6F
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, D641A MUTANT WITH BOUND PEPTIDE LIGAND SUC-GLY-PRO
分子名称: GLYCEROL, GLYCINE, PROLINE, ...
著者Rea, D, Fulop, V.
登録日2002-09-15
公開日2002-11-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase.
J. Biol. Chem., 277, 2002
1UOQ
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, S554A MUTANT WITH BOUND PEPTIDE LIGAND GLU-PHE-SER-PRO
分子名称: GLYCEROL, PEPTIDE LIGAND GLU-PHE-SER-PRO, PROLYL ENDOPEPTIDASE
著者Rea, D, Fulop, V.
登録日2003-09-22
公開日2003-10-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Electrostatic Environment at the Active Site of Prolyl Oligopeptidase is Highly Influential During Substrate Binding
J.Biol.Chem., 278, 2003
1H2Y
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, Y473F MUTANT WITH COVALENTLY BOUND INHIBITOR Z-PRO-PROLINAL
分子名称: GLYCEROL, N-BENZYLOXYCARBONYL-L-PROLYL-L-PROLINAL, PROLYL ENDOPEPTIDASE
著者Rea, D, Fulop, V.
登録日2002-08-20
公開日2002-11-11
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Electrostatic Effects and Binding Determinants in the Catalysis of Prolyl Oligopeptidase: Site Specific Mutagenesis at the Oxyanion Binding Site
J.Biol.Chem., 277, 2002
1H2X
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, Y473F MUTANT
分子名称: GLYCEROL, PROLYL ENDOPEPTIDASE
著者Fulop, V.
登録日2002-08-20
公開日2002-11-11
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Electrostatic Effects and Binding Determinants in the Catalysis of Prolyl Oligopeptidase: Site Specific Mutagenesis at the Oxyanion Binding Site
J.Biol.Chem., 277, 2002
1H2W
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN
分子名称: GLYCEROL, PROLYL ENDOPEPTIDASE
著者Fulop, V.
登録日2002-08-20
公開日2002-11-11
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Electrostatic Effects and Binding Determinants in the Catalysis of Prolyl Oligopeptidase: Site Specific Mutagenesis at the Oxyanion Binding Site
J.Biol.Chem., 277, 2002
1H2Z
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, S554A MUTANT WITH BOUND PEPTIDE LIGAND SUC-GLY-PRO
分子名称: GLYCEROL, GLYCINE, PROLINE, ...
著者Rea, D, Fulop, V.
登録日2002-08-20
公開日2002-11-11
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Electrostatic Effects and Binding Determinants in the Catalysis of Prolyl Oligopeptidase: Site Specific Mutagenesis at the Oxyanion Binding Site
J.Biol.Chem., 277, 2002
1E8M
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, MUTANT, COMPLEXED WITH INHIBITOR
分子名称: GLYCEROL, N-[(benzyloxy)carbonyl]glycyl-L-proline, PROLYL ENDOPEPTIDASE
著者Fulop, V.
登録日2000-09-27
公開日2001-01-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structures of Prolyl Oligopeptidase Substrate/ Inhibitor Complexes. Use of Inhibitor Binding for Titration of the Catalytic Histidine Residue
J.Biol.Chem., 276, 2001
1E8N
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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, MUTANT, COMPLEXED WITH PEPTIDE
分子名称: GLYCEROL, PEPTIDE INHIBITOR, PROLYL ENDOPEPTIDASE
著者Fulop, V.
登録日2000-09-27
公開日2001-01-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structures of Prolyl Oligopeptidase Substrate/ Inhibitor Complexes. Use of Inhibitor Binding for Titration of the Catalytic Histidine Residue
J.Biol.Chem., 276, 2001

 

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