6J4N
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![BU of 6j4n by Molmil](/molmil-images/mine/6j4n) | Structure of papua new guinea MBL-1(PNGM-1) native | 分子名称: | Metallo-beta-lactamases PNGM-1, ZINC ION | 著者 | Hong, M.K, Park, K.S, Jeon, J.H, Lee, J.H, Park, Y.S, Lee, S.H, Kang, L.W. | 登録日 | 2019-01-10 | 公開日 | 2019-02-27 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The novel metallo-beta-lactamase PNGM-1 from a deep-sea sediment metagenome: crystallization and X-ray crystallographic analysis. Acta Crystallogr F Struct Biol Commun, 74, 2018
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3UYU
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![BU of 3uyu by Molmil](/molmil-images/mine/3uyu) | Structural basis for the antifreeze activity of an ice-binding protein (LeIBP) from Arctic yeast | 分子名称: | Antifreeze protein, GLYCEROL | 著者 | Lee, J.H, Park, A.K, Do, H, Park, K.S, Moh, S.H, Chi, Y.M, Kim, H.J. | 登録日 | 2011-12-06 | 公開日 | 2012-02-15 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Structural basis for the antifreeze activity of an ice-binding protein from an Arctic yeast. J.Biol.Chem., 2012
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3UYV
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![BU of 3uyv by Molmil](/molmil-images/mine/3uyv) | Crystal structure of a glycosylated ice-binding protein (LeIBP) from Arctic yeast | 分子名称: | Antifreeze protein, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Lee, J.H, Park, A.K, Do, H, Park, K.S, Moh, S.H, Chi, Y.M, Kim, H.J. | 登録日 | 2011-12-06 | 公開日 | 2012-02-29 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Structural basis for the antifreeze activity of an ice-binding protein from an Arctic yeast. J.Biol.Chem., 2012
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7T7L
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![BU of 7t7l by Molmil](/molmil-images/mine/7t7l) | Structure of human G9a SET-domain (EHMT2) in complex with covalent inhibitor (Compound 1) | 分子名称: | Histone-lysine N-methyltransferase EHMT2, N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)prop-2-enamide, N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)propanamide, ... | 著者 | Park, K.-S, Kumar, P. | 登録日 | 2021-12-15 | 公開日 | 2022-07-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of the First-in-Class G9a/GLP Covalent Inhibitors. J.Med.Chem., 65, 2022
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7T7M
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![BU of 7t7m by Molmil](/molmil-images/mine/7t7m) | Structure of human GLP SET-domain (EHMT1) in complex with covalent inhibitor (Compound 1) | 分子名称: | Histone-lysine N-methyltransferase EHMT1, N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)prop-2-enamide, N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)propanamide, ... | 著者 | Park, K.-S, Kumar, P. | 登録日 | 2021-12-15 | 公開日 | 2022-07-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Discovery of the First-in-Class G9a/GLP Covalent Inhibitors. J.Med.Chem., 65, 2022
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6QPL
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![BU of 6qpl by Molmil](/molmil-images/mine/6qpl) | Crystal structure of Spindlin1 in complex with the inhibitor MS31 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Johansson, C, Krojer, T, Xiong, Y, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. | 登録日 | 2019-02-14 | 公開日 | 2019-07-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). J.Med.Chem., 62, 2019
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6W6D
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![BU of 6w6d by Molmil](/molmil-images/mine/6w6d) | Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with SGC6870 inhibitor | 分子名称: | (5R)-4-(5-bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one, Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Halabelian, L, Zeng, H, Dong, A, Jin, J, Shen, Y, Kaniskan, H.U, Hutchinson, A, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2020-03-16 | 公開日 | 2020-04-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. J.Med.Chem., 64, 2021
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6P7I
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![BU of 6p7i by Molmil](/molmil-images/mine/6p7i) | Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound | 分子名称: | GLYCEROL, N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]prop-2-enamide, N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]propanamide, ... | 著者 | Halabelian, L, Dong, A, Zeng, H, Li, Y, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2019-06-05 | 公開日 | 2019-06-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor J.Med.Chem., 63, 2020
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4QD4
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![BU of 4qd4 by Molmil](/molmil-images/mine/4qd4) | Structure of ADC-68, a Novel Carbapenem-Hydrolyzing Class C Extended-Spectrum -Lactamase from Acinetobacter baumannii | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase ADC-68, CITRIC ACID | 著者 | Hong, M.K, Kang, L.W. | 登録日 | 2014-05-13 | 公開日 | 2015-01-21 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of ADC-68, a novel carbapenem-hydrolyzing class C extended-spectrum beta-lactamase isolated from Acinetobacter baumannii Acta Crystallogr.,Sect.D, 70, 2014
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7JTP
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![BU of 7jtp by Molmil](/molmil-images/mine/7jtp) | Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | 分子名称: | Elongin-B, Elongin-C, GLYCEROL, ... | 著者 | Kottur, J, Jain, R, Aggarwal, A.K. | 登録日 | 2020-08-18 | 公開日 | 2021-10-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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7JTO
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![BU of 7jto by Molmil](/molmil-images/mine/7jto) | Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | 分子名称: | 1,2-ETHANEDIOL, 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, Elongin-B, ... | 著者 | Kottur, J, Jain, R, Aggarwal, A.K. | 登録日 | 2020-08-18 | 公開日 | 2021-10-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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4J7A
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![BU of 4j7a by Molmil](/molmil-images/mine/4j7a) | Crystal Structure of Est25 - a Bacterial Homolog of Hormone-Sensitive Lipase from a Metagenomic Library | 分子名称: | Esterase | 著者 | Ngo, T.D, Ryu, B.H, Ju, H.S, Jang, E.J, Park, K.S, Joo, S.B, Kim, K.K, Kim, D.H. | 登録日 | 2013-02-13 | 公開日 | 2014-01-15 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.492 Å) | 主引用文献 | Structural and functional analyses of a bacterial homologue of hormone-sensitive lipase from a metagenomic library Acta Crystallogr.,Sect.D, 69, 2014
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6JKW
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![BU of 6jkw by Molmil](/molmil-images/mine/6jkw) | Seleno-methionine PNGM-1 from deep-sea sediment metagenome | 分子名称: | Metallo-beta-lactamases PNGM-1, ZINC ION | 著者 | Hong, M.K, Park, K.S, Jeon, J.H, Lee, J.H, Park, Y.S, Lee, S.H, Kang, L.W. | 登録日 | 2019-03-02 | 公開日 | 2019-04-17 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | PNGM 1 a novel subclass B3 metallo beta lactamase from a deep sea sediment metagenome Journal of Global Antimicrobial Resistance, 14, 2018
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