7T7M

Structure of human GLP SET-domain (EHMT1) in complex with covalent inhibitor (Compound 1)

Summary for 7T7M

Entry DOI	10.2210/pdb7t7m/pdb
Descriptor	Histone-lysine N-methyltransferase EHMT1, ZINC ION, N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)prop-2-enamide, ... (5 entities in total)
Functional Keywords	glp, covalent inhibitor, gene regulation, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	134932.52
Authors	Park, K.-S.,Kumar, P. (deposition date: 2021-12-15, release date: 2022-07-06, Last modification date: 2023-10-18)
Primary citation	Park, K.S.,Xiong, Y.,Yim, H.,Velez, J.,Babault, N.,Kumar, P.,Liu, J.,Jin, J. Discovery of the First-in-Class G9a/GLP Covalent Inhibitors. J.Med.Chem., 65:10506-10522, 2022 Cited by PubMed: 35763668 DOI: 10.1021/acs.jmedchem.2c00652 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation