5UKA
| Salmonella typhimurium AhpC E49Q mutant | 分子名称: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ... | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | 登録日 | 2017-01-20 | 公開日 | 2018-01-24 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid.Redox Signal., 28, 2018
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4XRD
| Salmonella typhimurium AhpC W169F mutant | 分子名称: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ... | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | 登録日 | 2015-01-21 | 公開日 | 2016-01-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid.Redox Signal., 28, 2018
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4XS4
| Salmonella typhimurium AhpC C165S mutant | 分子名称: | Alkyl hydroperoxide reductase subunit C, POTASSIUM ION | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | 登録日 | 2015-01-21 | 公開日 | 2016-01-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid.Redox Signal., 28, 2018
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4XTS
| Salmonella typhimurium AhpC T43A mutant | 分子名称: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | 登録日 | 2015-01-24 | 公開日 | 2016-01-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.704 Å) | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid.Redox Signal., 28, 2018
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4XRA
| Salmonella typhimurium AhpC T43S mutant | 分子名称: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ... | 著者 | Perkins, A, Brereton, A.E, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | 登録日 | 2015-01-20 | 公開日 | 2016-01-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid.Redox Signal., 28, 2018
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4XS6
| Salmonella typhimurium AhpC W81F mutant | 分子名称: | Alkyl hydroperoxide reductase subunit C, POTASSIUM ION | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | 登録日 | 2015-01-21 | 公開日 | 2016-01-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid.Redox Signal., 28, 2018
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4XS1
| Salmonella typhimurium AhpC T43V mutant | 分子名称: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ... | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | 登録日 | 2015-01-21 | 公開日 | 2016-01-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid.Redox Signal., 28, 2018
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3SRS
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3SRU
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3SRQ
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3SRR
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3SQY
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3SR5
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3SRW
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3MVH
| Crystal structure of Akt-1-inhibitor complexes | 分子名称: | GSK3-beta peptide, MANGANESE (II) ION, N-{[(3S)-3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl}-2,4-difluorobenzamide, ... | 著者 | Pandit, J. | 登録日 | 2010-05-04 | 公開日 | 2010-06-02 | 最終更新日 | 2021-10-06 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
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3MV5
| Crystal structure of Akt-1-inhibitor complexes | 分子名称: | (3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine, GSK3-beta peptide, MANGANESE (II) ION, ... | 著者 | Pandit, J. | 登録日 | 2010-05-03 | 公開日 | 2010-06-02 | 最終更新日 | 2021-10-06 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
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3MVJ
| Human cyclic AMP-dependent protein kinase PKA inhibitor complex | 分子名称: | (3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | 著者 | Pandit, J, Vajdos, F. | 登録日 | 2010-05-04 | 公開日 | 2010-06-02 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
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6V1M
| Structure of NDM-1 bound to QPX7728 at 1.05 A | 分子名称: | (1~{a}~{R},7~{b}~{S})-5-fluoranyl-2,2-bis(oxidanyl)-1~{a},7~{b}-dihydro-1~{H}-cyclopropa[c][1,2]benzoxaborinine-4-carboxylic acid, Metallo-beta-lactamase type 2, ZINC ION | 著者 | Pemberton, O.A, Chen, Y. | 登録日 | 2019-11-20 | 公開日 | 2020-03-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-beta-lactamases. J.Med.Chem., 63, 2020
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6V1J
| Structure of KPC-2 bound to QPX7728 at 1.30 A | 分子名称: | (1aR,7bS)-5-fluoro-2-hydroxy-1,1a,2,7b-tetrahydrocyclopropa[c][1,2]benzoxaborinine-4-carboxylic acid, (1~{a}~{R},7~{b}~{S})-5-fluoranyl-2,2-bis(oxidanyl)-1~{a},7~{b}-dihydro-1~{H}-cyclopropa[c][1,2]benzoxaborinine-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, ... | 著者 | Pemberton, O.A, Chen, Y. | 登録日 | 2019-11-20 | 公開日 | 2020-03-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-beta-lactamases. J.Med.Chem., 63, 2020
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6V1P
| Structure of VIM-2 bound to QPX7728 at 1.20 A | 分子名称: | (1~{a}~{R},7~{b}~{S})-5-fluoranyl-2,2-bis(oxidanyl)-1~{a},7~{b}-dihydro-1~{H}-cyclopropa[c][1,2]benzoxaborinine-4-carboxylic acid, ACETATE ION, Beta-lactamase class B VIM-2, ... | 著者 | Pemberton, O.A, Chen, Y. | 登録日 | 2019-11-20 | 公開日 | 2020-03-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-beta-lactamases. J.Med.Chem., 63, 2020
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6V1O
| Structure of OXA-48 bound to QPX7728 at 1.80 A | 分子名称: | (1aR,7bS)-5-fluoro-2-hydroxy-1,1a,2,7b-tetrahydrocyclopropa[c][1,2]benzoxaborinine-4-carboxylic acid, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Pemberton, O.A, Chen, Y. | 登録日 | 2019-11-20 | 公開日 | 2020-03-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-beta-lactamases. J.Med.Chem., 63, 2020
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