6V1O
Structure of OXA-48 bound to QPX7728 at 1.80 A
Summary for 6V1O
Entry DOI | 10.2210/pdb6v1o/pdb |
Descriptor | OXA family beta-lactamase, (1aR,7bS)-5-fluoro-2-hydroxy-1,1a,2,7b-tetrahydrocyclopropa[c][1,2]benzoxaborinine-4-carboxylic acid, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | carbapenemase, boronate, inhibitor, beta-lactamase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 4 |
Total formula weight | 124632.78 |
Authors | Pemberton, O.A.,Chen, Y. (deposition date: 2019-11-20, release date: 2020-03-25, Last modification date: 2023-11-15) |
Primary citation | Hecker, S.J.,Reddy, K.R.,Lomovskaya, O.,Griffith, D.C.,Rubio-Aparicio, D.,Nelson, K.,Tsivkovski, R.,Sun, D.,Sabet, M.,Tarazi, Z.,Parkinson, J.,Totrov, M.,Boyer, S.H.,Glinka, T.W.,Pemberton, O.A.,Chen, Y.,Dudley, M.N. Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-beta-lactamases. J.Med.Chem., 63:7491-7507, 2020 Cited by PubMed: 32150407DOI: 10.1021/acs.jmedchem.9b01976 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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