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9E19
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BU of 9e19 by Molmil
Structure of RyR1 in the open state in the presence of pentoxifylline
分子名称: 3,7-DIMETHYL-1-(5-OXOHEXYL)-3,7-DIHYDRO-1H-PURINE-2,6-DIONE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ...
著者Miotto, M.C, Marks, A.R.
登録日2024-10-21
公開日2024-10-30
実験手法ELECTRON MICROSCOPY (4.04 Å)
主引用文献Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
9E1G
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BU of 9e1g by Molmil
Structure of RyR1 in the primed state in the presence of oxypurinol
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Oxypurinol, ...
著者Miotto, M.C, Marks, A.R.
登録日2024-10-21
公開日2024-10-30
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
9E1H
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BU of 9e1h by Molmil
Structure of RyR1 in the primed state in the presence of oxopyricid
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Miotto, M.C, Marks, A.R.
登録日2024-10-21
公開日2024-10-30
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
9E1E
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BU of 9e1e by Molmil
Structure of RyR1 in the primed state in the presence of uracil
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Miotto, M.C, Marks, A.R.
登録日2024-10-21
公開日2024-10-30
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
9E1I
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BU of 9e1i by Molmil
Structure of RyR1 in the open state in the presence of oxopyricid
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Miotto, M.C, Marks, A.R.
登録日2024-10-21
公開日2024-10-30
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
9E18
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BU of 9e18 by Molmil
Structure of RyR1 in the primed state in the presence of pentoxifylline
分子名称: 3,7-DIMETHYL-1-(5-OXOHEXYL)-3,7-DIHYDRO-1H-PURINE-2,6-DIONE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ...
著者Miotto, M.C, Marks, A.R.
登録日2024-10-21
公開日2024-10-30
実験手法ELECTRON MICROSCOPY (2.68 Å)
主引用文献Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
9E17
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BU of 9e17 by Molmil
Structure of RyR1 in the primed state in the presence of caffeine (reprocessed/reanalyzed from EMPIAR-10997, 7TZC, EMD-26205)
分子名称: (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Miotto, M.C, Marks, A.R.
登録日2024-10-21
公開日2024-10-30
実験手法ELECTRON MICROSCOPY (2.45 Å)
主引用文献Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
9E1B
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BU of 9e1b by Molmil
Structure of RyR1 in the open state in the presence of dyphylline
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Miotto, M.C, Marks, A.R.
登録日2024-10-21
公開日2024-10-30
実験手法ELECTRON MICROSCOPY (4.49 Å)
主引用文献Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
9E1F
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BU of 9e1f by Molmil
Structure of RyR1 in the primed state in the presence of allopurinol
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Miotto, M.C, Marks, A.R.
登録日2024-10-21
公開日2024-10-30
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
9E1A
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BU of 9e1a by Molmil
Structure of RyR1 in the primed state in the presence of dyphylline
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Miotto, M.C, Marks, A.R.
登録日2024-10-21
公開日2024-10-30
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
9E1D
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BU of 9e1d by Molmil
Structure of RyR1 in the primed state in the presence of enprofylline
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Miotto, M.C, Marks, A.R.
登録日2024-10-21
公開日2024-10-30
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
9E1C
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BU of 9e1c by Molmil
Structure of RyR1 in the primed state in the presence of IBMX
分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ...
著者Miotto, M.C, Marks, A.R.
登録日2024-10-21
公開日2024-10-30
実験手法ELECTRON MICROSCOPY (2.63 Å)
主引用文献Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
8UQ3
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BU of 8uq3 by Molmil
Structure of human RyR2-S2808D in the closed state in the presence of ARM210
分子名称: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-10-23
公開日2023-11-15
最終更新日2024-10-02
実験手法ELECTRON MICROSCOPY (3.18 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
8UQ4
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BU of 8uq4 by Molmil
Structure of human RyR2-S2808D in the subprimed state in the presence of H2O2/NOC-12/GSH
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-10-23
公開日2023-11-15
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.64 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
8UQ2
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BU of 8uq2 by Molmil
Structure of human RyR2-S2808D in the subprimed state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-10-23
公開日2023-11-15
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
8UXC
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BU of 8uxc by Molmil
Structure of PKA phosphorylated human RyR2-R420Q in the primed state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
8UQ5
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BU of 8uq5 by Molmil
Structure of human RyR2-S2808D in the primed state in the presence of Rapamycin
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Ryanodine receptor 2, ZINC ION
著者Miotto, M.C, Marks, A.R.
登録日2023-10-23
公開日2023-11-15
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (3.96 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
8UXE
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BU of 8uxe by Molmil
Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210
分子名称: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
8UXG
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BU of 8uxg by Molmil
Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210
分子名称: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
8UXH
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BU of 8uxh by Molmil
Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
8UXF
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BU of 8uxf by Molmil
Structure of PKA phosphorylated human RyR2-R420W in the primed state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
最終更新日2024-10-02
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
8UXL
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BU of 8uxl by Molmil
Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium and calmodulin
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
8UXM
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BU of 8uxm by Molmil
Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.56 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
8UXI
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BU of 8uxi by Molmil
Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
最終更新日2024-10-02
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
7U9X
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BU of 7u9x by Molmil
Structure of PKA phosphorylated human RyR2-R2474S in the closed state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ...
著者Miotto, M.C, Marks, A.R.
登録日2022-03-11
公開日2022-08-03
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (2.58 Å)
主引用文献Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Sci Adv, 8, 2022

 

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件を2024-11-06に公開中

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