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Prim-Pol Domain of CRISPR-associated Prim-Pol (CAPP) from Marinitoga sp. 1137 - Primer Initiation Complex
分子名称:	2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, COBALT (II) ION, GUANOSINE-5'-TRIPHOSPHATE, ...
著者	Li, A.W.H, Doherty, A.J.
登録日	2021-07-27
公開日	2022-05-04
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Molecular basis for the initiation of DNA primer synthesis. Nature, 605, 2022

7QAZ

Prim-Pol Domain of CRISPR-associated Prim-Pol (CAPP) from Marinitoga sp. 1137 - Primer Initiation Complex
分子名称:	2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, COBALT (II) ION, GUANOSINE-5'-TRIPHOSPHATE, ...
著者	Li, A.W.H, Doherty, A.J.
登録日	2021-11-17
公開日	2022-05-04
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.11 Å)
主引用文献	Molecular basis for the initiation of DNA primer synthesis. Nature, 605, 2022

7NQD

Prim-Pol Domain of CRISPR-associated Prim-Pol (CAPP) from Marinitoga sp. 1137
分子名称:	TPR_REGION domain-containing protein
著者	Li, A.W.H, Doherty, A.J.
登録日	2021-03-01
公開日	2022-05-04
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.97 Å)
主引用文献	Molecular basis for the initiation of DNA primer synthesis. Nature, 605, 2022

7NQF

Prim-Pol Domain of CRISPR-associated Prim-Pol (CAPP) from Marinitoga sp. 1137 with dsDNA
分子名称:	COBALT (II) ION, DNA(CGTGDG), TPR_REGION domain-containing protein
著者	Li, A.W.H, Doherty, A.J.
登録日	2021-03-01
公開日	2022-05-04
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.02 Å)
主引用文献	Molecular basis for the initiation of DNA primer synthesis. Nature, 605, 2022

7NQE

Prim-Pol Domain of CRISPR-associated Prim-Pol (CAPP) from Marinitoga sp. 1137 with dGTP
分子名称:	1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
著者	Li, A.W.H, Doherty, A.J.
登録日	2021-03-01
公開日	2022-05-04
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.28 Å)
主引用文献	Molecular basis for the initiation of DNA primer synthesis. Nature, 605, 2022

5HY6

Spodoptera frugiperda eukaryotic translation initiation factor EIF5A
分子名称:	Eukaryotic translation initiation factor 5A
著者	Li, A.W.H, Oliver, A.W, Pearl, L.H.
登録日	2016-02-01
公開日	2016-02-10
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.186 Å)
主引用文献	Structure of Spodoptera frugiperda eukaryotic translation initiation factor EIF5A To Be Published

5CU7

Bacteroides Thetaiotaomicron Multiple Inositol Polyphosphate Phosphatase A324D Mutant
分子名称:	PHOSPHATE ION, multiple inositol polyphosphate histidine phosphatase 1
著者	Li, A.W.H, Hemmings, A.M.
登録日	2015-07-24
公開日	2016-08-17
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (1.73 Å)
主引用文献	The Hydrolytic Positional Specificity Towards Phytic Acid of a Bacterial Multiple Inositol Polyphosphate Phosphatase To be published

5CX4

Crystal Structure of a Multiple Inositol Polyphosphate Phosphatase
分子名称:	PHOSPHATE ION, multiple inositol polyphosphate histidine phosphatase 1
著者	Li, A.W.H, Hemmings, A.M.
登録日	2015-07-28
公開日	2016-08-17
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.06 Å)
主引用文献	The Hydrolytic Positional Specificity Towards Phytic Acid of a Bacterial Multiple Inositol Polyphosphate Phosphatase To be published

6RXD

Crystal Structure of Bifidobacterium longum Multiple Inositol Polyphosphate Phosphatase Apo Form
分子名称:	Histidine acid phosphatase, ZINC ION
著者	Li, A.W.H, Brearley, C.A, Hemmings, A.M.
登録日	2019-06-07
公開日	2020-07-08
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced-fit structural mechanism. J.Biol.Chem., 295, 2020

8BGJ

Crystal structure of Reverse Transcriptase domain from Caloramator australicus CART-CAPP
分子名称:	L(+)-TARTARIC ACID, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ...
著者	Li, A.W.H, Doherty, A.J.
登録日	2022-10-27
公開日	2023-06-07
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.63 Å)
主引用文献	Reverse transcriptases prime DNA synthesis. Nucleic Acids Res., 51, 2023

8BAO

Dysgonamonadaceae bacterium CRISPR ancillary nuclease 2
分子名称:	BROMIDE ION, Cyclic tetra-adenylate (cA4), DUF1887 family protein, ...
著者	Li, A.W.H, Doherty, A.J.
登録日	2022-10-11
公開日	2022-11-30
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (2.06 Å)
主引用文献	Reverse transcriptases prime DNA synthesis. Nucleic Acids Res., 51, 2023

3QCY

Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 4-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide
分子名称:	(2S)-4-[2-amino-6-(3-amino-2H-indazol-6-yl)pyrimidin-4-yl]-N-phenylmorpholine-2-carboxamide, 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, ...
著者	Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M.
登録日	2011-01-17
公開日	2011-03-09
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011

3QCX

Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-{2-Amino-6-[(3R)-3-methyl-4-morpholinyl]-4-pyrimidinyl}-1H-indazol-3-amine
分子名称:	3-phosphoinositide-dependent protein kinase 1, 6-{2-amino-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-4-yl}-2H-indazol-3-amine, GLYCEROL, ...
著者	Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M.
登録日	2011-01-17
公開日	2011-03-09
最終更新日	2011-11-16
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011

3QCS

Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-[2-Amino-6-(4-morpholinyl)-4-pyrimidinyl]-1H-indazol-3-amine
分子名称:	3-phosphoinositide-dependent protein kinase 1, 6-[2-amino-6-(morpholin-4-yl)pyrimidin-4-yl]-2H-indazol-3-amine, GLYCEROL, ...
著者	Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M.
登録日	2011-01-17
公開日	2011-03-09
最終更新日	2017-11-08
実験手法	X-RAY DIFFRACTION (2.487 Å)
主引用文献	Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011

3QD0

Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with (2R,5S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide
分子名称:	(3S,6R)-1-[2-amino-6-(3-amino-2H-indazol-6-yl)pyrimidin-4-yl]-6-methyl-N-phenylpiperidine-3-carboxamide, 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, ...
著者	Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M.
登録日	2011-01-17
公開日	2011-03-09
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (1.99 Å)
主引用文献	Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011

3QCQ

Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-(3-Amino-1H-indazol-6-yl)-N4-ethyl-2,4-pyrimidinediamine
分子名称:	3-phosphoinositide-dependent protein kinase 1, 6-(3-amino-2H-indazol-6-yl)-N~4~-ethylpyrimidine-2,4-diamine, GLYCEROL, ...
著者	Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M.
登録日	2011-01-17
公開日	2011-03-09
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (2.501 Å)
主引用文献	Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011

3QD3

Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl {(3R,6S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-3-piperidinyl}carbamate
分子名称:	3-phosphoinositide-dependent protein kinase 1, GLYCEROL, SULFATE ION, ...
著者	Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M.
登録日	2011-01-17
公開日	2011-03-09
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011

3QD4

Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl{(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}carbamate
分子名称:	3-phosphoinositide-dependent protein kinase 1, SULFATE ION, tert-butyl {(3R,5R)-1-[2-amino-6-(3-amino-2H-indazol-6-yl)pyrimidin-4-yl]-5-methylpiperidin-3-yl}carbamate
著者	Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M.
登録日	2011-01-17
公開日	2011-03-09
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011

8OXE

Inositol 1,3,4-trisphosphate 5/6-kinase 1 from Solanum tuberosum (StITPK1) in complex with ADP/Mg2+
分子名称:	ADENOSINE-5'-DIPHOSPHATE, Inositol-tetrakisphosphate 1-kinase, MAGNESIUM ION
著者	Faba-Rodriguez, R, Li, A.W.H, Brearley, C.A, Hemmings, A.M.
登録日	2023-05-02
公開日	2024-03-27
実験手法	X-RAY DIFFRACTION (2.26 Å)
主引用文献	Crystal Structure and Enzymology of Solanum tuberosum Inositol Tris/Tetrakisphosphate Kinase 1 ( St ITPK1). Biochemistry, 63, 2024

7DJT

Human SARM1 inhibitory state bounded with inhibitor dHNN
分子名称:	NAD(+) hydrolase SARM1, O3-methyl O5-(2-methylpropyl) 2,6-dimethyl-4-[2-(oxidanylamino)phenyl]pyridine-3,5-dicarboxylate
著者	Cai, Y, Zhang, H.
登録日	2020-11-21
公開日	2021-05-19
最終更新日	2023-11-15
実験手法	ELECTRON MICROSCOPY (2.8 Å)
主引用文献	Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate. Elife, 10, 2021

4FDU

Crystal Structure of a Multiple Inositol Polyphosphate Phosphatase
分子名称:	1,2-ETHANEDIOL, D-MYO-INOSITOL-HEXASULPHATE, Putative multiple inositol polyphosphate histidine phosphatase 1
著者	Li, A.W.H, Hemmings, A.M.
登録日	2012-05-29
公開日	2014-01-29
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.293 Å)
主引用文献	A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut. Cell Rep, 6, 2014

4FDT

Crystal Structure of a Multiple Inositol Polyphosphate Phosphatase
分子名称:	1,2-ETHANEDIOL, PHOSPHATE ION, Putative multiple inositol polyphosphate histidine phosphatase 1
著者	Li, A.W.H, Hemmings, A.M.
登録日	2012-05-29
公開日	2014-01-29
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.93 Å)
主引用文献	A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut. Cell Rep, 6, 2014

8GNJ

Human SARM1 bounded with NMN and Nanobody-C6, Conformation 2
分子名称:	BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1, Nanobody-C6
著者	Cai, Y, Zhang, H.
登録日	2022-08-24
公開日	2023-01-18
実験手法	ELECTRON MICROSCOPY (3.78 Å)
主引用文献	A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Nat Commun, 13, 2022

8GNI

Human SARM1 bounded with NMN and Nanobody-C6, Conformation 1
分子名称:	BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1, Nanobody C6
著者	Cai, Y, Zhang, H.
登録日	2022-08-24
公開日	2023-01-18
実験手法	ELECTRON MICROSCOPY (3.74 Å)
主引用文献	A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Nat Commun, 13, 2022

8GQ5

Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure
分子名称:	NAD(+) hydrolase SARM1, Nanobody C6
著者	Cai, Y, Zhang, H.
登録日	2022-08-29
公開日	2023-01-18
実験手法	ELECTRON MICROSCOPY (2.7 Å)
主引用文献	A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Nat Commun, 13, 2022

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