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8TB7
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BU of 8tb7 by Molmil
Cryo-EM Structure of GPR61-
分子名称: 6-{[(3,5-difluoropyridin-4-yl)methyl]amino}-N-(4-ethoxy-6-methylpyrimidin-2-yl)-2-methoxy-N-(2-methoxyethyl)pyridine-3-sulfonamide, Fab hinge-binding nanobody, Fab24 BAK5 heavy chain, ...
著者Lees, J.A, Dias, J.M, Han, S.
登録日2023-06-28
公開日2023-10-04
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Nat Commun, 14, 2023
8TB0
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BU of 8tb0 by Molmil
Cryo-EM Structure of GPR61-G protein complex stabilized by scFv16
分子名称: GPR61 fused to dominant negative G alpha S/I N18 chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Lees, J.A, Dias, J.M, Han, S.
登録日2023-06-28
公開日2023-10-04
実験手法ELECTRON MICROSCOPY (3.47 Å)
主引用文献An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Nat Commun, 14, 2023
7K2V
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BU of 7k2v by Molmil
PIKfyve/Fig4/Vac14 complex centered on PIKfyve - map2
分子名称: 1-phosphatidylinositol 3-phosphate 5-kinase
著者Lees, J.A, Reinisch, K.M, Li, P.
登録日2020-09-09
公開日2020-10-21
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (6.6 Å)
主引用文献Insights into Lysosomal PI(3,5)P 2 Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex.
Mol.Cell, 80, 2020
7K1W
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BU of 7k1w by Molmil
PIKfyve/Fig4/Vac14 complex centered on Fig4 - map3
分子名称: Fig4 Sac homology model
著者Lees, J.A, Reinisch, K.M, Li, P.
登録日2020-09-08
公開日2020-10-21
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (5.1 Å)
主引用文献Insights into Lysosomal PI(3,5)P 2 Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex.
Mol.Cell, 80, 2020
7K1Y
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BU of 7k1y by Molmil
PIKfyve/Fig4/Vac14 complex centered on Vac14 - map1
分子名称: Vac14
著者Lees, J.A, Reinisch, K.M, Li, P.
登録日2020-09-08
公開日2020-10-21
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (5.25 Å)
主引用文献Insights into Lysosomal PI(3,5)P 2 Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex.
Mol.Cell, 80, 2020
6BQ1
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BU of 6bq1 by Molmil
Human PI4KIIIa lipid kinase complex
分子名称: 5-{2-amino-1-[4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide, Phosphatidylinositol 4-kinase III alpha (PI4KA), Protein FAM126A, ...
著者Lees, J.A, Zhang, Y, Oh, M, Schauder, C.M, Yu, X, Baskin, J, Dobbs, K, Notarangelo, L.D, Camilli, P.D, Walz, T, Reinisch, K.M.
登録日2017-11-27
公開日2017-12-13
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Architecture of the human PI4KIII alpha lipid kinase complex.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5TOD
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BU of 5tod by Molmil
Transmembrane protein 24 SMP domain
分子名称: Transmembrane protein 24
著者Lees, J.A, Reinisch, K.M.
登録日2016-10-17
公開日2017-03-01
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.
Science, 355, 2017
7UJA
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BU of 7uja by Molmil
Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, AM14 Fab heavy chain, AM14 Fab light chain, ...
著者Lees, J.A, Ammirati, M, Han, S.
登録日2022-03-30
公開日2023-04-19
最終更新日2023-05-10
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine.
Sci Transl Med, 15, 2023
7L7F
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BU of 7l7f by Molmil
Cryo-EM structure of human ACE2 receptor bound to protein encoded by vaccine candidate BNT162b1
分子名称: Angiotensin-converting enzyme 2, Spike glycoprotein, Envelope glycoprotein fusion
著者Lees, J.A, Han, S.
登録日2020-12-28
公開日2021-02-24
最終更新日2021-04-21
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献BNT162b vaccines protect rhesus macaques from SARS-CoV-2.
Nature, 592, 2021
7L7K
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BU of 7l7k by Molmil
Cryo-EM structure of protein encoded by vaccine candidate BNT162b2
分子名称: Spike glycoprotein
著者Lees, J.A, Han, S.
登録日2020-12-28
公開日2021-02-24
最終更新日2021-04-21
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献BNT162b vaccines protect rhesus macaques from SARS-CoV-2.
Nature, 592, 2021
7UJ3
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BU of 7uj3 by Molmil
Crystal structure of Human respiratory syncytial virus F variant (construct pXCS847A)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, RSV variant (construct pXCS847A) F1, RSV variant (construct pXCS847A) F2, ...
著者Han, S, Ammirati, M.
登録日2022-03-30
公開日2023-04-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine.
Sci Transl Med, 15, 2023
6CBC
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BU of 6cbc by Molmil
Crystal structure of an N-terminal fragment of Vps13.
分子名称: Vacuolar protein sorting-associated protein
著者Kumar, N, Horenkamp, F.A, Reinisch, K.M.
登録日2018-02-02
公開日2018-08-08
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites.
J. Cell Biol., 217, 2018
6ITL
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BU of 6itl by Molmil
Crystal structure of malate dehydrogenase from Mannheimia succiniciproducens in complex with NAD
分子名称: GLYCEROL, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Seo, H, Kim, K.-J.
登録日2018-11-23
公開日2019-11-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase.
Nat Commun, 11, 2020
7YO8
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BU of 7yo8 by Molmil
Crystal structure of fission yeast Hfl1 LIR fused to human GABARAPL2
分子名称: Transmembrane protein 184 homolog C30D11.06c,Gamma-aminobutyric acid receptor-associated protein-like 2
著者Yamasaki, A, Noda, N.N.
登録日2022-08-01
公開日2022-11-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.805 Å)
主引用文献Development of new tools to study membrane-anchored mammalian Atg8 proteins.
Autophagy, 19, 2023
7YO9
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BU of 7yo9 by Molmil
Crystal structure of fusion protein of human TP53INP2 LIR and human GABARAP
分子名称: ISOPROPYL ALCOHOL, PHOSPHATE ION, Tumor protein p53-inducible nuclear protein 2,Gamma-aminobutyric acid receptor-associated protein
著者Yamasaki, A, Noda, N.N.
登録日2022-08-01
公開日2022-11-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Development of new tools to study membrane-anchored mammalian Atg8 proteins.
Autophagy, 19, 2023
6ITK
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BU of 6itk by Molmil
Crystal structure of malate dehydrogenase from Corynebacterium glutamicum ATCC 13032 in complex with NAD and malate
分子名称: (2S)-2-hydroxybutanedioic acid, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Seo, H, Kim, K.-J.
登録日2018-11-23
公開日2019-11-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase.
Nat Commun, 11, 2020
8RFB
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BU of 8rfb by Molmil
Cryo-EM structure of the R243C mutant of human Prolyl Endopeptidase-Like (PREPL) protein involved in Congenital myasthenic syndrome-22 (CMS22)
分子名称: Prolyl endopeptidase-like
著者Theodoropoulou, A, Cavani, E, Antanasijevic, A, Marcaida, M.J, Dal Peraro, M.
登録日2023-12-12
公開日2024-09-04
最終更新日2024-09-18
実験手法ELECTRON MICROSCOPY (4.01 Å)
主引用文献Missense variants in CMS22 patients reveal that PREPL has both enzymatic and nonenzymatic functions.
JCI Insight, 9, 2024
5TPR
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BU of 5tpr by Molmil
Desmethyl-4-deoxygadusol synthase from Anabaena variabilis (Ava_3858) with NAD+ and Zn2+ bound
分子名称: 3-dehydroquinate synthase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Kean, K.M, Karplus, P.A.
登録日2016-10-21
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Evolution and Distribution of C7-Cyclitol Synthases in Prokaryotes and Eukaryotes.
ACS Chem. Biol., 12, 2017

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件を2024-09-18に公開中

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