1NTP
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1TGN
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3PGF
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![BU of 3pgf by Molmil](/molmil-images/mine/3pgf) | Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB) | 分子名称: | GLYCEROL, IMIDAZOLE, Maltose-binding periplasmic protein, ... | 著者 | Kossiakoff, A.A, Duguid, E.M, Sandstrom, A. | 登録日 | 2010-11-01 | 公開日 | 2011-03-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nat.Struct.Mol.Biol., 18, 2011
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2R8S
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![BU of 2r8s by Molmil](/molmil-images/mine/2r8s) | High resolution structure of a specific synthetic FAB bound to P4-P6 RNA ribozyme domain | 分子名称: | Fab heavy chain, Fab light chain, MAGNESIUM ION, ... | 著者 | Ye, J.D, Tereshko, V, Sidhu, S.S, Koide, S, Kossiakoff, A.A, Piccirilli, J.A. | 登録日 | 2007-09-11 | 公開日 | 2007-12-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Synthetic antibodies for specific recognition and crystallization of structured RNA Proc.Natl.Acad.Sci.Usa, 105, 2008
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6RLX
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7ZYI
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![BU of 7zyi by Molmil](/molmil-images/mine/7zyi) | Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody | 分子名称: | CHOLESTEROL, GLYCOCHENODEOXYCHOLIC ACID, Nanobody, ... | 著者 | Liu, H, Irobalieva, R.N, Bang-Sorensen, R, Nosol, K, Mukherjee, S, Agrawal, P, Stieger, B, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2022-05-24 | 公開日 | 2022-07-13 | 最終更新日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver. Cell Res., 32, 2022
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2FXU
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![BU of 2fxu by Molmil](/molmil-images/mine/2fxu) | X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Rizvi, S.A, Tereshko, V, Kossiakoff, A.A, Kozmin, S.A. | 登録日 | 2006-02-06 | 公開日 | 2006-03-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structure of bistramide a-actin complex at a 1.35 A resolution J.Am.Chem.Soc., 128, 2006
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7PHP
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![BU of 7php by Molmil](/molmil-images/mine/7php) | Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM | 分子名称: | Anti-Fab nanobody, Multidrug resistance protein NorM, NabFab HC, ... | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Niederer, M, Pardon, E, Steyaert, J, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2021-08-18 | 公開日 | 2021-09-01 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7PIJ
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![BU of 7pij by Molmil](/molmil-images/mine/7pij) | Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | 分子名称: | Anti-Fab nanobody, DMTNb16_4, Divalent metal cation transporter MntH, ... | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2021-08-20 | 公開日 | 2021-09-01 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7PHQ
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![BU of 7phq by Molmil](/molmil-images/mine/7phq) | Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | 分子名称: | Anti-Fab nanobody, DMT-Nb16_4, Divalent metal cation transporter MntH, ... | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2021-08-18 | 公開日 | 2021-09-01 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (8.45 Å) | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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5W2B
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![BU of 5w2b by Molmil](/molmil-images/mine/5w2b) | Crystal structure of C-terminal domain of Ebola (Reston) nucleoprotein in complex with Fab fragment | 分子名称: | Fab Heavy Chain, Fab Light Chain, Nucleoprotein | 著者 | Radwanska, M.J, Derewenda, U, Kossiakoff, A.A, Derewenda, Z.S. | 登録日 | 2017-06-06 | 公開日 | 2018-06-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab. Acta Crystallogr D Struct Biol, 74, 2018
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1KF9
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![BU of 1kf9 by Molmil](/molmil-images/mine/1kf9) | PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR | 分子名称: | EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238), PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE | 著者 | Schiffer, C.A, Ultsch, M, Walsh, S, Somers, W, De Vos, A.M, Kossiakoff, A.A. | 登録日 | 2001-11-19 | 公開日 | 2002-11-20 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites J.Mol.Biol., 316, 2002
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3BOG
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![BU of 3bog by Molmil](/molmil-images/mine/3bog) | Snow Flea Antifreeze Protein Quasi-racemate | 分子名称: | 6.5 kDa glycine-rich antifreeze protein, UNKNOWN LIGAND | 著者 | Pentelute, B.L, Kent, S.B.H, Gates, Z.P, Tereshko, V, Kossiakoff, A.A, Kurutz, J, Dashnau, J, Vaderkooi, J.M. | 登録日 | 2007-12-17 | 公開日 | 2008-09-23 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers J.Am.Chem.Soc., 130, 2008
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3BOI
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![BU of 3boi by Molmil](/molmil-images/mine/3boi) | Snow Flea Antifreeze Protein Racemate | 分子名称: | 6.5 kDa glycine-rich antifreeze protein | 著者 | Pentelute, B.L, Kent, S.B.H, Gates, Z.P, Tereshko, V, Kossiakoff, A.A, Kurutz, J, Dashnau, J, Vaderkooi, J.M. | 登録日 | 2007-12-17 | 公開日 | 2008-09-23 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers J.Am.Chem.Soc., 130, 2008
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8PG0
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![BU of 8pg0 by Molmil](/molmil-images/mine/8pg0) | Human OATP1B3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHOLESTEROL, ... | 著者 | Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2023-06-17 | 公開日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structure of human drug transporters OATP1B1 and OATP1B3. Nat Commun, 14, 2023
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8PHW
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![BU of 8phw by Molmil](/molmil-images/mine/8phw) | Human OATP1B1 | 分子名称: | CHOLESTEROL HEMISUCCINATE, Fab18 (heavy chain, variable region), ... | 著者 | Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2023-06-20 | 公開日 | 2023-09-27 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of human drug transporters OATP1B1 and OATP1B3. Nat Commun, 14, 2023
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8THE
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![BU of 8the by Molmil](/molmil-images/mine/8the) | Cryo-EM structure of Pseudomonas aeruginosa TonB-dependent transporter PhuR in complex with synthetic antibody and heme | 分子名称: | (2~{R},4~{R},5~{S},6~{S})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{R},4~{R},5~{S},6~{S})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{S})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-4,5-bis(oxidanyl)oxane-2-carboxylic acid, Heme/hemoglobin uptake outer membrane receptor PhuR, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Knejski, P, Erramilli, S.K, Kossiakoff, A.A. | 登録日 | 2023-07-15 | 公開日 | 2024-01-31 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding. Structure, 32, 2024
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6SNI
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![BU of 6sni by Molmil](/molmil-images/mine/6sni) | Cryo-EM structure of nanodisc reconstituted yeast ALG6 in complex with 6AG9 Fab | 分子名称: | 6AG9-Fab heavy chain, 6AG9-Fab light chain, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | 登録日 | 2019-08-24 | 公開日 | 2020-03-11 | 最終更新日 | 2020-04-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure and mechanism of the ER-based glucosyltransferase ALG6. Nature, 579, 2020
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6U8C
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![BU of 6u8c by Molmil](/molmil-images/mine/6u8c) | Crystal structure of an engineered ultra-high affinity Fab-Protein G complex | 分子名称: | Antibody heavy chain Fab, Antibody light chain Fab, Protein G | 著者 | Slezak, T, Filippova, E.V, Davydova, E.K, Kossiakoff, A.A. | 登録日 | 2019-09-04 | 公開日 | 2019-10-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability. Protein Sci., 29, 2020
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6SNH
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![BU of 6snh by Molmil](/molmil-images/mine/6snh) | Cryo-EM structure of yeast ALG6 in complex with 6AG9 Fab and Dol25-P-Glc | 分子名称: | 6AG9 Fab heavy chain, 6AG9 Fab light chain, Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase, ... | 著者 | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | 登録日 | 2019-08-24 | 公開日 | 2020-03-11 | 最終更新日 | 2020-04-01 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure and mechanism of the ER-based glucosyltransferase ALG6. Nature, 579, 2020
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6UKJ
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![BU of 6ukj by Molmil](/molmil-images/mine/6ukj) | Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform | 分子名称: | CHOLESTEROL HEMISUCCINATE, Chloroquine resistance transporter, Fab Heavy Chain, ... | 著者 | Kim, J, Tan, Y.Z, Wicht, K.J, Erramilli, S.K, Dhingra, S.K, Okombo, J, Vendome, J, Hagenah, L.M, Giacometti, S.I, Warren, A.L, Nosol, K, Roepe, P.D, Potter, C.S, Carragher, B, Kossiakoff, A.A, Quick, M, Fidock, D.A, Mancia, F. | 登録日 | 2019-10-05 | 公開日 | 2019-12-04 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure and drug resistance of the Plasmodium falciparum transporter PfCRT. Nature, 576, 2019
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8SLB
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![BU of 8slb by Molmil](/molmil-images/mine/8slb) | X-ray structure of CorA N-terminal domain in complex with conformation-specific synthetic antibody C12 | 分子名称: | CHLORIDE ION, Cobalt/magnesium transport protein CorA, sAB C12 Heavy Chain, ... | 著者 | Dominik, P.K, Erramilli, S.K, Reddy, B.G, Kossiakoff, A.A. | 登録日 | 2023-04-21 | 公開日 | 2023-06-07 | 最終更新日 | 2023-07-26 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA. J.Mol.Biol., 435, 2023
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4XTR
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![BU of 4xtr by Molmil](/molmil-images/mine/4xtr) | Structure of Get3 bound to the transmembrane domain of Pep12 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase GET3, ... | 著者 | Mateja, A, Paduch, M, Chang, H.-Y, Szydlowska, A, Kossiakoff, A.A, Hegde, R.S, Keenan, R.J. | 登録日 | 2015-01-23 | 公開日 | 2015-03-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo. Science, 347, 2015
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4XH2
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![BU of 4xh2 by Molmil](/molmil-images/mine/4xh2) | Crystal structure of human paxillin LD4 motif in complex with Fab fragment | 分子名称: | ACETATE ION, ACETYL GROUP, Fab Heavy Chain, ... | 著者 | Nocula-Lugowska, M, Lugowski, M, Salgia, R, Kossiakoff, A.A. | 登録日 | 2015-01-04 | 公開日 | 2015-07-01 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin. J.Mol.Biol., 427, 2015
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4XMN
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![BU of 4xmn by Molmil](/molmil-images/mine/4xmn) | Structure of the yeast coat nucleoporin complex, space group P212121 | 分子名称: | Antibody 87 heavy chain, Antibody 87 light chain, Nucleoporin NUP120, ... | 著者 | Stuwe, T, Correia, A.R, Lin, D.H, Paduch, M, Lu, V.T, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2015-01-14 | 公開日 | 2015-03-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (7.6 Å) | 主引用文献 | Nuclear pores. Architecture of the nuclear pore complex coat. Science, 347, 2015
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