2AUD
 
 | | Unliganded HincII | | 分子名称: | Type II restriction enzyme HincII | | 著者 | Horton, N.C, Little, E.J. | | 登録日 | 2005-08-27 | | 公開日 | 2005-10-04 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | DNA-induced conformational changes in Type II restriction endonucleases: The structure of unliganded HincII
J.Mol.Biol., 351, 2005
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1KC6
 | | HincII Bound to Cognate DNA | | 分子名称: | 5'-D(P*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*G)-3', SODIUM ION, TYPE II RESTRICTION ENZYME HINCII | | 著者 | Horton, N.C, Dorner, L.F, Perona, J.J. | | 登録日 | 2001-11-07 | | 公開日 | 2001-12-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Sequence selectivity and degeneracy of a restriction endonuclease mediated by DNA intercalation.
Nat.Struct.Biol., 9, 2002
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1SX5
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1SX8
 | | EcoRV bound to cognate DNA and Mn2+ | | 分子名称: | 5'-D(*C*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3', MANGANESE (II) ION, Type II restriction enzyme EcoRV | | 著者 | Horton, N.C, Perona, J.J. | | 登録日 | 2004-03-30 | | 公開日 | 2004-04-06 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | DNA Cleavage by EcoRV Endonuclease: Two Metal Ions in Three Metal Ion Binding Sites
Biochemistry, 43, 2004
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1STX
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1SUZ
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1RV5
 | | COMPLEX OF ECORV ENDONUCLEASE WITH D(AAAGAT)/D(ATCTT) | | 分子名称: | 5'-D(*AP*AP*AP*GP*AP*T*AP*TP*CP*TP*T)-3', ECORV ENDONUCLEASE | | 著者 | Horton, N.C, Perona, J.J. | | 登録日 | 1998-06-01 | | 公開日 | 1998-11-11 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Role of protein-induced bending in the specificity of DNA recognition: crystal structure of EcoRV endonuclease complexed with d(AAAGAT) + d(ATCTT).
J.Mol.Biol., 277, 1998
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1EO3
 | | INHIBITION OF ECORV ENDONUCLEASE BY DEOXYRIBO-3'-S-PHOSPHOROTHIOLATES: A HIGH RESOLUTION X-RAY CRYSTALLOGRAPHIC STUDY | | 分子名称: | ACETIC ACID, DNA (5'-D(*CP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3'), MAGNESIUM ION, ... | | 著者 | Horton, N.C, Connolly, B.A, Perona, J.J. | | 登録日 | 2000-03-21 | | 公開日 | 2000-04-04 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study
J.Am.Chem.Soc., 122, 2000
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1EO4
 | | ECORV BOUND TO MN2+ AND COGNATE DNA CONTAINING A 3'S SUBSTITION AT THE CLEAVAGE SITE | | 分子名称: | ACETIC ACID, DNA (5'-D(*CP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3'), MANGANESE (II) ION, ... | | 著者 | Horton, N.C, Connolly, B.A, Perona, J.J. | | 登録日 | 2000-03-21 | | 公開日 | 2000-04-04 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study
J.Am.Chem.Soc., 122, 2000
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1FIX
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1EON
 | | ECORV BOUND TO 3'-S-PHOSPHOROTHIOLATE DNA AND CA2+ | | 分子名称: | ACETIC ACID, CHLORIDE ION, DNA (5'-D(*AP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3'), ... | | 著者 | Horton, N.C, Connolly, B.A, Perona, J.J. | | 登録日 | 2000-03-23 | | 公開日 | 2000-04-04 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study
J.Am.Chem.Soc., 122, 2000
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1EOO
 | | ECORV BOUND TO COGNATE DNA | | 分子名称: | DNA (5'-D(*GP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*C)-3'), TYPE II RESTRICTION ENZYME ECORV | | 著者 | Horton, N.C, Perona, J.J. | | 登録日 | 2000-03-23 | | 公開日 | 2000-04-04 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Crystallographic snapshots along a protein-induced DNA-bending pathway.
Proc.Natl.Acad.Sci.USA, 97, 2000
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1EOP
 | | ECORV BOUND TO COGNATE DNA | | 分子名称: | DNA (5'-D(*GP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*C)-3'), TYPE II RESTRICTION ENZYME ECORV | | 著者 | Horton, N.C, Perona, J.J. | | 登録日 | 2000-03-23 | | 公開日 | 2000-04-04 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystallographic snapshots along a protein-induced DNA-bending pathway.
Proc.Natl.Acad.Sci.USA, 97, 2000
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1TX3
 | | HINCII BOUND TO COGNATE DNA | | 分子名称: | 5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*G)-3', SODIUM ION, Type II restriction enzyme HindII | | 著者 | Horton, N.C, Dorner, L.F, Perona, J.J. | | 登録日 | 2004-07-01 | | 公開日 | 2005-02-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Ca2+ binding in the active site of HincII: implications for the catalytic mechanism
Biochemistry, 43, 2004
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1BGB
 | | ECORV ENDONUCLEASE COMPLEX WITH 5'-CGGGATATCCC DNA | | 分子名称: | DNA (5'-D(*CP*GP*GP*GP*AP*TP*AP*TP*CP*CP*C)-3'), ECORV ENDONUCLEASE | | 著者 | Perona, J, Horton, N.C. | | 登録日 | 1998-05-28 | | 公開日 | 1998-10-28 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Recognition of flanking DNA sequences by EcoRV endonuclease involves alternative patterns of water-mediated contacts.
J.Biol.Chem., 273, 1998
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1BSS
 | | ECORV-T93A/DNA/CA2+ | | 分子名称: | 5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3', CALCIUM ION, ECORV ENDONUCLEASE | | 著者 | Perona, J.J, Horton, N.C. | | 登録日 | 1998-08-30 | | 公開日 | 1998-09-02 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases
Proc.Natl.Acad.Sci.USA, 95, 1998
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2GIJ
 | | Q138F HincII bound to cognate DNA GTTAAC and Ca2+ | | 分子名称: | 5'-D(*GP*CP*CP*GP*GP*TP*TP*AP*AP*CP*CP*GP*GP*C)-3', CALCIUM ION, SODIUM ION, ... | | 著者 | Horton, N.C, Joshi, H.K. | | 登録日 | 2006-03-28 | | 公開日 | 2006-07-18 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
J.Biol.Chem., 281, 2006
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2GIH
 | | Q138F HincII bound to cognate DNA GTCGAC and Ca2+ | | 分子名称: | 5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*GP*C)-3', CALCIUM ION, Type II restriction enzyme HincII | | 著者 | Horton, N.C, Joshi, H.K, Etzkorn, C, Chatwell, L, Bitinaite, J. | | 登録日 | 2006-03-28 | | 公開日 | 2006-07-18 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
J.Biol.Chem., 281, 2006
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2GII
 | | Q138F HincII bound to cognate DNA GTTAAC | | 分子名称: | 5'-D(*GP*CP*CP*GP*GP*TP*TP*AP*AP*CP*CP*GP*GP*C)-3', Type II restriction enzyme HincII | | 著者 | Horton, N.C, Joshi, H.K. | | 登録日 | 2006-03-28 | | 公開日 | 2006-07-18 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
J.Biol.Chem., 281, 2006
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2GIG
 | | Alteration of sequence specificity of the type II restriction endonuclease HINCII through an indirect readout mechanism | | 分子名称: | 5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*GP*C)-3', SODIUM ION, Type II restriction enzyme HincII | | 著者 | Horton, N.C, Joshi, H.K, Etzkorn, C, Chatwell, L, Bitinaite, J. | | 登録日 | 2006-03-28 | | 公開日 | 2006-07-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
J.Biol.Chem., 281, 2006
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2GIE
 | | HincII bound to cognate DNA GTTAAC | | 分子名称: | 5'-D(*GP*CP*CP*GP*GP*TP*TP*AP*AP*CP*CP*GP*G)-3', SODIUM ION, Type II restriction enzyme HincII | | 著者 | Horton, N.C, Joshi, H.K, Etzkorn, C, Chatwell, L, Bitinaite, J. | | 登録日 | 2006-03-28 | | 公開日 | 2006-07-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
J.Biol.Chem., 281, 2006
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3N7B
 | | SgrAI bound to secondary site DNA and Ca(II) | | 分子名称: | CALCIUM ION, DNA (5'-D(*AP*GP*TP*CP*CP*AP*CP*CP*GP*GP*GP*GP*GP*AP*CP*T)-3'), DNA (5'-D(*AP*GP*TP*CP*CP*CP*CP*CP*GP*GP*TP*GP*GP*AP*CP*T)-3'), ... | | 著者 | Horton, N.C, Little, E.J, Dunten, P.W. | | 登録日 | 2010-05-26 | | 公開日 | 2010-11-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | New clues in the allosteric activation of DNA cleavage by SgrAI: structures of SgrAI bound to cleaved primary-site DNA and uncleaved secondary-site DNA.
Acta Crystallogr.,Sect.D, 67, 2011
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3N78
 | | SgrAI bound to Secondary Site DNA and Mg(II) | | 分子名称: | DNA (5'-D(*AP*GP*TP*CP*CP*AP*CP*CP*GP*GP*GP*GP*GP*AP*CP*T)-3'), DNA (5'-D(*AP*GP*TP*CP*CP*CP*CP*CP*GP*GP*TP*GP*GP*AP*CP*T)-3'), MAGNESIUM ION, ... | | 著者 | Horton, N.C, Little, E.J, Dunten, P.W. | | 登録日 | 2010-05-26 | | 公開日 | 2010-11-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | New clues in the allosteric activation of DNA cleavage by SgrAI: structures of SgrAI bound to cleaved primary-site DNA and uncleaved secondary-site DNA.
Acta Crystallogr.,Sect.D, 67, 2011
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2I13
 | | Aart, a six finger zinc finger designed to recognize ANN triplets | | 分子名称: | 5'-D(*CP*AP*GP*AP*TP*GP*TP*AP*GP*GP*GP*AP*AP*AP*AP*GP*CP*CP*CP*GP*GP*G)-3', 5'-D(*GP*CP*CP*CP*GP*GP*GP*CP*TP*TP*TP*TP*CP*CP*CP*TP*AP*CP*AP*TP*CP*T)-3', Aart, ... | | 著者 | Horton, N.C, Segal, D.J, Bhakta, M, Crotty, J.W, Barbas III, C.F. | | 登録日 | 2006-08-12 | | 公開日 | 2006-10-03 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Structure of Aart, a Designed Six-finger Zinc Finger Peptide, Bound to DNA.
J.Mol.Biol., 363, 2006
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3E44
 | | Q138F HincII bound to cleaved DNA (GTT | AAC) and Mn2+ | | 分子名称: | 5'-D(*DGP*DCP*DCP*DGP*DGP*DTP*DT)-3', 5'-D(P*DAP*DAP*DCP*DCP*DGP*DGP*DC)-3', MANGANESE (II) ION, ... | | 著者 | Horton, N.C, Babic, A.C, Little, E.J, Manohar, V.M. | | 登録日 | 2008-08-08 | | 公開日 | 2008-08-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | DNA distortion and specificity in a sequence-specific endonuclease.
J.Mol.Biol., 383, 2008
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