8SMV
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![BU of 8smv by Molmil](/molmil-images/mine/8smv) | GPR161 Gs heterotrimer | 分子名称: | CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hoppe, N, Manglik, A, Harrison, S. | 登録日 | 2023-04-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Biorxiv, 2023
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1XCT
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![BU of 1xct by Molmil](/molmil-images/mine/1xct) | Complex HCV core-Fab 19D9D6-Protein L mutant (D55A, L57H, Y64W) in space group P21212 | 分子名称: | Capsid protein C, Monoclonal antibody 19D9D6 Heavy chain, Monoclonal antibody 19D9D6 Light chain, ... | 著者 | Menez, R, Housden, N.G, Harrison, S, Jolivet-Reynaud, C, Gore, M.G, Stura, E.A. | 登録日 | 2004-09-03 | 公開日 | 2005-05-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Different crystal packing in Fab-protein L semi-disordered peptide complex. Acta Crystallogr.,Sect.D, 61, 2005
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1XF5
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![BU of 1xf5 by Molmil](/molmil-images/mine/1xf5) | Complex HCV core-Fab 19D9D6-Protein L mutant (H74C, Y64W)in space group P21212 | 分子名称: | Capsid protein C, Monoclonal antibody 19D9D6 Heavy chain, Monoclonal antibody 19D9D6 Light chain, ... | 著者 | Menez, R, Housden, N.G, Harrison, S, Jolivet-Reynaud, C, Gore, M.G, Stura, E.A. | 登録日 | 2004-09-14 | 公開日 | 2005-05-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Different crystal packing in Fab-protein L semi-disordered peptide complex. Acta Crystallogr.,Sect.D, 61, 2005
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1YMH
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![BU of 1ymh by Molmil](/molmil-images/mine/1ymh) | anti-HCV Fab 19D9D6 complexed with protein L (PpL) mutant A66W | 分子名称: | Fab 16D9D6, heavy chain, light chain, ... | 著者 | Granata, V, Housden, N.G, Harrison, S, Jolivet-Reynaud, C, Gore, M.G, Stura, E.A. | 登録日 | 2005-01-21 | 公開日 | 2005-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Comparison of the crystallization and crystal packing of two Fab single-site mutant protein L complexes. Acta Crystallogr.,Sect.D, 61, 2005
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1XCQ
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![BU of 1xcq by Molmil](/molmil-images/mine/1xcq) | Complex HCV core-Fab 19D9D6-Protein L mutant (D55A,L57H,Y64W) in space group P21 | 分子名称: | Capsid protein C, Monoclonal antibody 19D9D6 Heavy chain, Monoclonal antibody 19D9D6 Light chain, ... | 著者 | Menez, R, Housden, N.G, Harrison, S, Jolivet-Reynaud, C, Gore, M.G, Stura, E.A. | 登録日 | 2004-09-03 | 公開日 | 2005-05-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Different crystal packing in Fab-protein L semi-disordered peptide complex. Acta Crystallogr.,Sect.D, 61, 2005
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2KVN
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![BU of 2kvn by Molmil](/molmil-images/mine/2kvn) | Phi29 E-loop hairpin | 分子名称: | RNA (5'-R(*GP*GP*UP*GP*AP*UP*UP*GP*AP*GP*UP*UP*CP*AP*CP*CP*A)-3') | 著者 | Harris, S.M, Schroeder, S.J. | 登録日 | 2010-03-19 | 公開日 | 2010-07-07 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Nuclear magnetic resonance structure of the prohead RNA E-loop hairpin. Biochemistry, 49, 2010
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2N5G
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![BU of 2n5g by Molmil](/molmil-images/mine/2n5g) | NMR structure of KorA, a plasmid-encoded, global transcription regulator KorA | 分子名称: | TrfB transcriptional repressor protein | 著者 | Rajasekar, K.V, Lovering, A.L, Dancea, F.V, Scott, D.J, Harris, S, Bingle, L.E, Roessle, M, Thomas, C.M, Hyde, E.I, White, S.A. | 登録日 | 2015-07-17 | 公開日 | 2016-07-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Flexibility of KorA, a plasmid-encoded, global transcription regulator, in the presence and the absence of its operator. Nucleic Acids Res., 44, 2016
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4HVI
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![BU of 4hvi by Molmil](/molmil-images/mine/4hvi) | |
4HVH
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![BU of 4hvh by Molmil](/molmil-images/mine/4hvh) | |
4HVG
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![BU of 4hvg by Molmil](/molmil-images/mine/4hvg) | |
4HVD
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![BU of 4hvd by Molmil](/molmil-images/mine/4hvd) | JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1,2,2-trimethyl-propyl)-amide | 分子名称: | 1-phenylurea, 2-cyclopropyl-N-[(2S)-3,3-dimethylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase JAK3 | 著者 | Kuglstatter, A, Shao, A. | 登録日 | 2012-11-06 | 公開日 | 2013-01-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | 3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models. J.Med.Chem., 56, 2013
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3D14
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![BU of 3d14 by Molmil](/molmil-images/mine/3d14) | Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]- thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea | 分子名称: | 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea, serine/threonine kinase 6 | 著者 | Elling, R.A, Baskaran, S, Allen, D.A, Oslob, J.D, Romanowski, M.J. | 登録日 | 2008-05-04 | 公開日 | 2008-08-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of a potent and selective aurora kinase inhibitor. Bioorg.Med.Chem.Lett., 18, 2008
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3D15
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![BU of 3d15 by Molmil](/molmil-images/mine/3d15) | Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-(3-chloro-phenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)- ethyl]-thiazol-2-yl}-urea [SNS-314] | 分子名称: | 1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea, serine/threonine kinase 6 | 著者 | Elling, R.A, Bui, M, Allen, D.A, Oslob, J.D, Romanowski, M.J. | 登録日 | 2008-05-04 | 公開日 | 2009-05-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of a potent and selective aurora kinase inhibitor. Bioorg.Med.Chem.Lett., 18, 2008
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4PCO
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7LX2
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![BU of 7lx2 by Molmil](/molmil-images/mine/7lx2) | Cryo-EM structure of ConSOSL.UFO.664 (ConS) in complex with bNAb PGT122 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Env glycoprotein gp160, ... | 著者 | Martin, G.M, Ward, A.B, Sattentau, Q.J. | 登録日 | 2021-03-03 | 公開日 | 2022-03-09 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens. Npj Vaccines, 8, 2023
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7LX3
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![BU of 7lx3 by Molmil](/molmil-images/mine/7lx3) | Cryo-EM structure of EDC-crosslinked ConSOSL.UFO.664 (ConS-EDC) in complex with bNAb PGT122 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Env glycoprotein gp160, ... | 著者 | Martin, G.M, Ward, A.B, Sattentau, Q.J. | 登録日 | 2021-03-03 | 公開日 | 2022-03-09 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens. Npj Vaccines, 8, 2023
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7LXM
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![BU of 7lxm by Molmil](/molmil-images/mine/7lxm) | Cryo-EM structure of ConM SOSIP.v7 (ConM) in complex with bNAb PGT122 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Env glycoprotein gp120, ... | 著者 | Martin, G.M, Ward, A.B, Sattentau, Q.J. | 登録日 | 2021-03-04 | 公開日 | 2022-03-09 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens. Npj Vaccines, 8, 2023
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7LXN
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![BU of 7lxn by Molmil](/molmil-images/mine/7lxn) | Cryo-EM structure of EDC-crosslinked ConM SOSIP.v7 (ConM-EDC) in complex with bNAb PGT122 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Env glycoprotein gp120, ... | 著者 | Martin, G.M, Ward, A.B, Sattentau, Q.J. | 登録日 | 2021-03-04 | 公開日 | 2022-03-09 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | 主引用文献 | Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens. Npj Vaccines, 8, 2023
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8TQD
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![BU of 8tqd by Molmil](/molmil-images/mine/8tqd) | NF-Kappa-B1 Bound with a Covalent Inhibitor | 分子名称: | 1-(2-bromo-4-chlorophenyl)-N-{(3S)-1-[(E)-iminomethyl]pyrrolidin-3-yl}methanesulfonamide, Nuclear factor NF-kappa-B p105 subunit | 著者 | Hilbert, B.J. | 登録日 | 2023-08-07 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell, 187, 2024
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4WTU
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![BU of 4wtu by Molmil](/molmil-images/mine/4wtu) | Crystal structure of BACE1 in complex with 2-aminooxazoline 3-aza-4-fluoro-xanthene inhibitor 22 | 分子名称: | (5S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine, Beta-secretase 1, GLYCEROL, ... | 著者 | Whittington, D.A, Long, A.M. | 登録日 | 2014-10-30 | 公開日 | 2015-03-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | An Orally Available BACE1 Inhibitor That Affords Robust CNS A beta Reduction without Cardiovascular Liabilities. Acs Med.Chem.Lett., 6, 2015
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7KW1
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![BU of 7kw1 by Molmil](/molmil-images/mine/7kw1) | Structure of hSTING in complex with novel carbocyclic pyrimidine CDN-3 | 分子名称: | (2R,5R,7R,8R,10R,12aR,14R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-16-hydroxy-14-[(pyrimidin-4-yl)oxy]-2,10-disulfanyldecahydro-2H,10H-5,8-methano-2lambda~5~,10lambda~5~-cyclopenta[l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | 著者 | Skene, R. | 登録日 | 2020-11-29 | 公開日 | 2021-06-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route. J.Med.Chem., 64, 2021
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7KVX
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![BU of 7kvx by Molmil](/molmil-images/mine/7kvx) | Structure of hSTING in complex with novel carbocyclic pyrimidine CDN 1 | 分子名称: | (2R,5R,7R,8R,10R,12aR,14R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-16-hydroxy-14-[(pyrimidin-4-yl)amino]-2,10-disulfanyldecahydro-2H,10H-5,8-methano-2lambda~5~,10lambda~5~-cyclopenta[l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | 著者 | Skene, R. | 登録日 | 2020-11-29 | 公開日 | 2021-06-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route. J.Med.Chem., 64, 2021
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7KVZ
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![BU of 7kvz by Molmil](/molmil-images/mine/7kvz) | Structure of hSTING in complex with novel carbocyclic pyrimidine CDN-2 | 分子名称: | (2R,5R,7R,8R,10S,12aR,14R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2,10,16-trihydroxy-14-[(pyrimidin-4-yl)oxy]decahydro-2H,10H-5,8-methano-2lambda~5~,10lambda~5~-cyclopenta[l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | 著者 | Skene, R.J. | 登録日 | 2020-11-29 | 公開日 | 2022-02-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route. J.Med.Chem., 64, 2021
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1MHH
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![BU of 1mhh by Molmil](/molmil-images/mine/1mhh) | |
1LCJ
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![BU of 1lcj by Molmil](/molmil-images/mine/1lcj) | |