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3TS8
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BU of 3ts8 by Molmil
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
分子名称: CDKN1A(p21) anti-sense strand, CDKN1A(p21) sense strand, Cellular tumor antigen p53, ...
著者Halazonetis, T.D, Emamzadah, S.
登録日2011-09-12
公開日2011-11-23
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element.
Mol Cancer Res, 9, 2011
1XNI
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BU of 1xni by Molmil
Tandem Tudor Domain of 53BP1
分子名称: Tumor suppressor p53-binding protein 1
著者Huyen, Y, Zgheib, O, DiTullio Jr, R.A, Gorgoulis, V.G, Zacharatos, P, Petty, T.J, Sheston, E.A, Mellert, H.S, Stavridi, E.S, Halazonetis, T.D.
登録日2004-10-05
公開日2004-11-30
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Nature, 432, 2004
7P2G
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BU of 7p2g by Molmil
Identification of low micromolar SARS-CoV-2 Mpro inhibitors from hits identified by in silico screens
分子名称: (4~{R})-~{N}-(4-iodophenyl)-2-oxidanylidene-3,4-dihydro-1~{H}-quinoline-4-carboxamide, 3C-like proteinase
著者Rempel, S, Halazonetis, T.D.
登録日2021-07-05
公開日2022-05-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Non-covalent SARS-CoV-2 M pro inhibitors developed from in silico screen hits.
Sci Rep, 12, 2022
1T4W
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BU of 1t4w by Molmil
Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1
分子名称: C.Elegans p53 tumor suppressor-like transcription factor, ZINC ION
著者Huyen, Y, Jeffrey, P.D, Derry, W.B, Rothman, J.H, Pavletich, N.P, Stavridi, E.S, Halazonetis, T.D.
登録日2004-04-30
公開日2004-07-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Differences in the DNA Binding Domains of Human p53 and Its C. elegans Ortholog Cep-1.
Structure, 12, 2004
4MZR
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BU of 4mzr by Molmil
Crystal structure of a polypeptide p53 mutant bound to DNA
分子名称: Cellular tumor antigen p53, ZINC ION, consensus DNA anti-sense strand, ...
著者Emamzadah, S.T, Tropia, L, Vincenti, I, Falquet, B, Halazonetis, T.D.
登録日2013-09-30
公開日2014-01-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein.
J.Mol.Biol., 426, 2014
4MZI
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BU of 4mzi by Molmil
Crystal structure of a human mutant p53
分子名称: Cellular tumor antigen p53, ZINC ION
著者Emamzadah, S, Tropia, L, Vincenti, I, Falquet, B, Halazonetis, T.D.
登録日2013-09-30
公開日2014-01-15
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein.
J.Mol.Biol., 426, 2014
1LGP
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BU of 1lgp by Molmil
Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein complexed with tungstate
分子名称: TUNGSTATE(VI)ION, cell cycle checkpoint protein CHFR
著者Stavridi, E.S, Huyen, Y, Loreto, I.R, Scolnick, D.M, Halazonetis, T.D, Pavletich, N.P, Jeffrey, P.D.
登録日2002-04-16
公開日2002-05-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.
Structure, 10, 2002
1LGQ
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BU of 1lgq by Molmil
Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein
分子名称: cell cycle checkpoint protein CHFR
著者Stavridi, E.S, Huyen, Y, Loreto, I.R, Scolnick, D.M, Halazonetis, T.D, Pavletich, N.P, Jeffrey, P.D.
登録日2002-04-16
公開日2002-05-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.
Structure, 10, 2002
3Q01
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BU of 3q01 by Molmil
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
分子名称: Cellular tumor antigen p53, ZINC ION
著者Petty, T.J, Halazonetis, T.D.
登録日2010-12-15
公開日2011-05-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
Embo J., 30, 2011
3Q05
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BU of 3q05 by Molmil
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
分子名称: Cellular tumor antigen p53, DNA (26-MER), ZINC ION
著者Petty, T.J, Halazonetis, T.D.
登録日2010-12-15
公開日2011-05-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
Embo J., 30, 2011
3Q06
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BU of 3q06 by Molmil
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
分子名称: Cellular tumor antigen p53, DNA (26-MER), ZINC ION
著者Petty, T.J, Halazonetis, T.D.
登録日2010-12-15
公開日2011-05-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
Embo J., 30, 2011
3VEM
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BU of 3vem by Molmil
Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1
分子名称: Helicase protein MOM1
著者Nishikura, T, Petty, T.J, Halazonetis, T, Paszkowski, J, Thore, S.
登録日2012-01-09
公開日2012-03-07
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural Basis of Transcriptional Gene Silencing Mediated by Arabidopsis MOM1.
PLOS GENET., 8, 2012
1A1U
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BU of 1a1u by Molmil
SOLUTION STRUCTURE DETERMINATION OF A P53 MUTANT DIMERIZATION DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称: P53
著者Mccoy, M.A, Stavridi, E.S, Waterman, J.L.F, Wieczorek, A, Opella, S.J, Halezonetis, T.D.
登録日1997-12-16
公開日1998-04-08
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain.
EMBO J., 16, 1997
4QLI
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A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
分子名称: 14-3-3 protein sigma, GLYCEROL, MAGNESIUM ION, ...
著者Bier, D, Ottmann, C.
登録日2014-06-12
公開日2015-06-17
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
To be Published

222036

件を2024-07-03に公開中

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