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PDB: 16 results

3TS8
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BU of 3ts8 by Molmil
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
Descriptor: CDKN1A(p21) anti-sense strand, CDKN1A(p21) sense strand, Cellular tumor antigen p53, ...
Authors:Halazonetis, T.D, Emamzadah, S.
Deposit date:2011-09-12
Release date:2011-11-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element.
Mol Cancer Res, 9, 2011
3VEM
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BU of 3vem by Molmil
Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1
Descriptor: Helicase protein MOM1
Authors:Nishikura, T, Petty, T.J, Halazonetis, T, Paszkowski, J, Thore, S.
Deposit date:2012-01-09
Release date:2012-03-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis of Transcriptional Gene Silencing Mediated by Arabidopsis MOM1.
PLOS GENET., 8, 2012
7P2G
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BU of 7p2g by Molmil
Identification of low micromolar SARS-CoV-2 Mpro inhibitors from hits identified by in silico screens
Descriptor: (4~{R})-~{N}-(4-iodophenyl)-2-oxidanylidene-3,4-dihydro-1~{H}-quinoline-4-carboxamide, 3C-like proteinase
Authors:Rempel, S, Halazonetis, T.D.
Deposit date:2021-07-05
Release date:2022-05-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-covalent SARS-CoV-2 M pro inhibitors developed from in silico screen hits.
Sci Rep, 12, 2022
5O8K
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BU of 5o8k by Molmil
Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895
Descriptor: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Emamzadah, S, Tropia, L, Huber, F, Halazonetis, T.
Deposit date:2017-06-13
Release date:2018-06-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895
To Be Published
1XNI
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BU of 1xni by Molmil
Tandem Tudor Domain of 53BP1
Descriptor: Tumor suppressor p53-binding protein 1
Authors:Huyen, Y, Zgheib, O, DiTullio Jr, R.A, Gorgoulis, V.G, Zacharatos, P, Petty, T.J, Sheston, E.A, Mellert, H.S, Stavridi, E.S, Halazonetis, T.D.
Deposit date:2004-10-05
Release date:2004-11-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Nature, 432, 2004
4MZR
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BU of 4mzr by Molmil
Crystal structure of a polypeptide p53 mutant bound to DNA
Descriptor: Cellular tumor antigen p53, ZINC ION, consensus DNA anti-sense strand, ...
Authors:Emamzadah, S.T, Tropia, L, Vincenti, I, Falquet, B, Halazonetis, T.D.
Deposit date:2013-09-30
Release date:2014-01-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein.
J.Mol.Biol., 426, 2014
3Q01
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BU of 3q01 by Molmil
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Petty, T.J, Halazonetis, T.D.
Deposit date:2010-12-15
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
Embo J., 30, 2011
3Q05
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BU of 3q05 by Molmil
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
Descriptor: Cellular tumor antigen p53, DNA (26-MER), ZINC ION
Authors:Petty, T.J, Halazonetis, T.D.
Deposit date:2010-12-15
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
Embo J., 30, 2011
3Q06
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BU of 3q06 by Molmil
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
Descriptor: Cellular tumor antigen p53, DNA (26-MER), ZINC ION
Authors:Petty, T.J, Halazonetis, T.D.
Deposit date:2010-12-15
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
Embo J., 30, 2011
4MZI
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BU of 4mzi by Molmil
Crystal structure of a human mutant p53
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Emamzadah, S, Tropia, L, Vincenti, I, Falquet, B, Halazonetis, T.D.
Deposit date:2013-09-30
Release date:2014-01-15
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein.
J.Mol.Biol., 426, 2014
1T4W
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BU of 1t4w by Molmil
Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1
Descriptor: C.Elegans p53 tumor suppressor-like transcription factor, ZINC ION
Authors:Huyen, Y, Jeffrey, P.D, Derry, W.B, Rothman, J.H, Pavletich, N.P, Stavridi, E.S, Halazonetis, T.D.
Deposit date:2004-04-30
Release date:2004-07-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Differences in the DNA Binding Domains of Human p53 and Its C. elegans Ortholog Cep-1.
Structure, 12, 2004
1LGP
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BU of 1lgp by Molmil
Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein complexed with tungstate
Descriptor: TUNGSTATE(VI)ION, cell cycle checkpoint protein CHFR
Authors:Stavridi, E.S, Huyen, Y, Loreto, I.R, Scolnick, D.M, Halazonetis, T.D, Pavletich, N.P, Jeffrey, P.D.
Deposit date:2002-04-16
Release date:2002-05-08
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.
Structure, 10, 2002
1LGQ
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BU of 1lgq by Molmil
Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein
Descriptor: cell cycle checkpoint protein CHFR
Authors:Stavridi, E.S, Huyen, Y, Loreto, I.R, Scolnick, D.M, Halazonetis, T.D, Pavletich, N.P, Jeffrey, P.D.
Deposit date:2002-04-16
Release date:2002-05-08
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.
Structure, 10, 2002
6EKM
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BU of 6ekm by Molmil
Crystal structure of mammalian Rev7 in complex with human Rev3 second binding site
Descriptor: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Huber, F, Tropia, L, Emamzadah, S, Halazonetis, T.
Deposit date:2017-09-26
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Crystal structure of mammalian Rev7 in complex with human Rev3
To Be Published
6EKJ
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Crystal structure of mammalian Rev7 in complex with human Chromosome alignment-maintaining phosphoprotein 1
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Huber, F, Tropia, L, Emamzadah, S, Halazonetis, T.
Deposit date:2017-09-26
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of mammalian Rev7 in complex with Champ1 - CAPS molecule
To Be Published
6EKL
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BU of 6ekl by Molmil
Crystal structure of mammalian Rev7 in complex with human Chromosome alignment-maintaining phosphoprotein 1
Descriptor: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Huber, F, Tropia, L, Emamzadah, S, Halazonetis, T.
Deposit date:2017-09-26
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of mammalian Rev7 in complex with Champ1
To Be Published

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