4WZF
 
 | | Crystal structural basis for Rv0315, an immunostimulatory antigen and pseudo beta-1, 3-glucanase of Mycobacterium tuberculosis | | 分子名称: | 1,2-ETHANEDIOL, 1,3-beta-glucanase, CALCIUM ION | | 著者 | Dong, W.Y, Fu, Z.F, Peng, G.Q. | | 登録日 | 2014-11-19 | | 公開日 | 2015-12-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | | 主引用文献 | Crystal structural basis for Rv0315, an immunostimulatory antigen and inactive beta-1,3-glucanase of Mycobacterium tuberculosis.
Sci Rep, 5, 2015
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4XFQ
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4ZUH
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6IVD
 | | TGEV nsp1 mutant - 91-95sg | | 分子名称: | nsp1 mutant protein | | 著者 | Shen, Z, Peng, G.Q. | | 登録日 | 2018-12-03 | | 公開日 | 2019-08-07 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.975 Å) | | 主引用文献 | A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence.
J.Biol.Chem., 294, 2019
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6IVC
 | | The full length of TGEV nsp1 | | 分子名称: | nsp1 protein | | 著者 | Shen, Z, Peng, G.Q. | | 登録日 | 2018-12-03 | | 公開日 | 2019-08-07 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence.
J.Biol.Chem., 294, 2019
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4Z5V
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5Y4L
 | | PRRSV nsp4 | | 分子名称: | Non-structural protein | | 著者 | Shi, Y.J, Gang, Y, Peng, G.Q. | | 登録日 | 2017-08-04 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | | 主引用文献 | Identification of two antiviral inhibitors targeting 3C-like serine/3C-like protease of porcine reproductive and respiratory syndrome virus and porcine epidemic diarrhea virus.
Vet. Microbiol., 213, 2018
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6L70
 | | Complex structure of PEDV 3CLpro with GC376 | | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, PEDV main protease | | 著者 | Ye, G, Peng, G.Q. | | 登録日 | 2019-10-30 | | 公開日 | 2020-04-29 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376.
Viruses, 12, 2020
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6LPA
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6LKX
 | | The structure of PRRSV helicase | | 分子名称: | CITRIC ACID, GLYCEROL, RNA-dependent RNA polymerase, ... | | 著者 | Shi, Y.J, Tong, X.H, Peng, G.Q. | | 登録日 | 2019-12-20 | | 公開日 | 2020-05-27 | | 最終更新日 | 2021-06-09 | | 実験手法 | X-RAY DIFFRACTION (2.998 Å) | | 主引用文献 | Structural Characterization of the Helicase nsp10 Encoded by Porcine Reproductive and Respiratory Syndrome Virus.
J.Virol., 94, 2020
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6LN0
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6LP9
 | | the protein of cat virus | | 分子名称: | nsp1 protein | | 著者 | Shen, Z, Peng, G.Q. | | 登録日 | 2020-01-09 | | 公開日 | 2020-08-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | | 主引用文献 | Structural and Biological Basis of Alphacoronavirus nsp1 Associated with Host Proliferation and Immune Evasion.
Viruses, 12, 2020
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7CBT
 | | The crystal structure of SARS-CoV-2 main protease in complex with GC376 | | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase | | 著者 | Shi, Y, Peng, G. | | 登録日 | 2020-06-13 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.346 Å) | | 主引用文献 | The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract.
Emerg Microbes Infect, 10, 2021
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7CYD
 | | Cryo-EM structures of Alphacoronavirus spike glycoprotein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Song, X, Shi, Y, Ding, W, Liu, Z.J, Peng, G. | | 登録日 | 2020-09-03 | | 公開日 | 2020-12-23 | | 最終更新日 | 2021-06-02 | | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | | 主引用文献 | Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes.
Nat Commun, 12, 2021
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7CYC
 | | Cryo-EM structures of Alphacoronavirus spike glycoprotein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Song, X, Shi, Y, Ding, W, Liu, Z.J, Peng, G. | | 登録日 | 2020-09-03 | | 公開日 | 2020-12-23 | | 最終更新日 | 2021-06-02 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes.
Nat Commun, 12, 2021
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