6L70

Complex structure of PEDV 3CLpro with GC376

Summary for 6L70

Entry DOI	10.2210/pdb6l70/pdb
Descriptor	PEDV main protease, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total)
Functional Keywords	3c-like protease, complex, hydrolase
Biological source	Porcine epidemic diarrhea virus
Total number of polymer chains	2
Total formula weight	67562.38
Authors	Ye, G.,Peng, G.Q. (deposition date: 2019-10-30, release date: 2020-04-29, Last modification date: 2023-11-22)
Primary citation	Ye, G.,Wang, X.,Tong, X.,Shi, Y.,Fu, Z.F.,Peng, G. Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376. Viruses, 12:-, 2020 Cited by PubMed: 32098094 DOI: 10.3390/v12020240 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation