8P1I
| Single particle cryo-EM co-structure of Klebsiella pneumoniae AcrB with the BDM91288 efflux pump inhibitor at 2.97 Angstrom resolution | 分子名称: | 1,2-DIOCTANOYL-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL), 3-chloranyl-2,6-di(piperazin-4-ium-1-yl)quinoline, Efflux pump membrane transporter, ... | 著者 | Boernsen, C, Mueller, R.T, Pos, K.M, Frangakis, A.S. | 登録日 | 2023-05-12 | 公開日 | 2024-01-17 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae. Embo Mol Med, 16, 2024
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8P4I
| Cyanide dihydratase from Bacillus pumilus C1 | 分子名称: | Cyanide dihydratase | 著者 | Mulelu, A.E, Reitz, J, van Rooyen, J.M, Scheffer, M, Frangakis, A.S, Dlamini, L.S, Woodward, J.D, Benedik, M.J, Sewell, B.T. | 登録日 | 2023-05-22 | 公開日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.83 Å) | 主引用文献 | The Role of Histidine Residues in the Oligomerization of Cyanide Dihydratase from Bacillus pumilus C1 To Be Published
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8PBY
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8PC1
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8PBX
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8C5I
| Cyanide dihydratase from Bacillus pumilus C1 variant - Q86R,H305K,H308K,H323K | 分子名称: | Cyanide dihydratase | 著者 | Mulelu, A.E, Reitz, J, van Rooyen, J, Scheffer, M, Frangakis, A.S, Dlamini, L.S, Woodward, J.D, Benedik, M.J, Sewell, B.T. | 登録日 | 2023-01-09 | 公開日 | 2023-01-18 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | The Role of Histidine Residues in the Oligomerization of Cyanide Dihydratase from Bacillus pumilus C1 To Be Published
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7A7D
| Cadherin fit into cryo-ET map | 分子名称: | Desmocollin-2, Desmoglein-2 | 著者 | Sikora, M, Ermel, U.H, Seybold, A, Kunz, M, Calloni, G, Reitz, J, Vabulas, R.M, Hummer, G, Frangakis, A.S. | 登録日 | 2020-08-28 | 公開日 | 2020-12-23 | 実験手法 | ELECTRON MICROSCOPY (26 Å) | 主引用文献 | Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography. Proc.Natl.Acad.Sci.USA, 117, 2020
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5M3F
| Yeast RNA polymerase I elongation complex at 3.8A | 分子名称: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | 著者 | Neyer, S, Kunz, M, Geiss, C, Hantsche, M, Hodirnau, V.-V, Seybert, A, Engel, C, Scheffer, M.P, Cramer, P, Frangakis, A.S. | 登録日 | 2016-10-14 | 公開日 | 2016-11-23 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of RNA polymerase I transcribing ribosomal DNA genes. Nature, 540, 2016
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5M3M
| Free monomeric RNA polymerase I at 4.0A resolution | 分子名称: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | 著者 | Neyer, S, Kunz, M, Geiss, C, Hantsche, M, Hodirnau, V.-V, Seybert, A, Engel, C, Scheffer, M.P, Cramer, P, Frangakis, A.S. | 登録日 | 2016-10-15 | 公開日 | 2016-11-23 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure of RNA polymerase I transcribing ribosomal DNA genes. Nature, 540, 2016
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6TLZ
| N-Domain P40/P90 Mycoplasma pneumoniae complexed with 3'SL | 分子名称: | Mgp-operon protein 3, N-acetyl-alpha-neuraminic acid, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ... | 著者 | Vizarraga, D, Aparicio, D, Illanes, R, Fita, I, Perez-Luque, R, Martin, J. | 登録日 | 2019-12-03 | 公開日 | 2020-11-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae. Nat Commun, 11, 2020
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8PC0
| Sub-tomogram average of the open conformation of the Nap adhesion complex from the human pathogen Mycoplasma genitalium. | 分子名称: | Adhesin P1, Mgp-operon protein 3, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-1,5-anhydro-D-glucitol, ... | 著者 | Sprankel, L, Scheffer, M.P, Frangakis, A.F. | 登録日 | 2023-06-09 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (17 Å) | 主引用文献 | Cryo-electron tomography reveals the binding and release states of the major adhesion complex from Mycoplasma genitalium. Plos Pathog., 19, 2023
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8PBZ
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7B8Q
| Acinetobacter baumannii multidrug transporter AdeB in L*OO state | 分子名称: | Efflux pump membrane transporter | 著者 | Ornik-Cha, A, Reitz, J, Seybert, A, Frangakis, A, Pos, K.M. | 登録日 | 2020-12-13 | 公開日 | 2021-10-20 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun, 12, 2021
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7B8P
| Acinetobacter baumannii multidrug transporter AdeB in OOO state | 分子名称: | Efflux pump membrane transporter | 著者 | Ornik-Cha, A, Reitz, J, Seybert, A, Frangakis, A, Pos, K.M. | 登録日 | 2020-12-13 | 公開日 | 2021-10-20 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun, 12, 2021
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9FCH
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8A9B
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8A9A
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6YRK
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7B8S
| Fusidic acid bound structure of bacterial efflux pump. | 分子名称: | DARPin, FUSIDIC ACID, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | 著者 | Wilhelm, J, Sjuts, H, Pos, K.M. | 登録日 | 2020-12-13 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun, 12, 2021
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7B8T
| Levofloxacin bound structure of bacterial efflux pump. | 分子名称: | (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | 著者 | Wilhelm, J, Sjuts, H, Pos, K.M. | 登録日 | 2020-12-13 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun, 12, 2021
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7B8R
| Doxycycline bound structure of bacterial efflux pump. | 分子名称: | (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, DARPin, DI(HYDROXYETHYL)ETHER, ... | 著者 | Wilhelm, J, Sjuts, H, Pos, K.M. | 登録日 | 2020-12-13 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun, 12, 2021
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6QDW
| Cryo-EM structure of the 50S ribosomal subunit at 2.83 Angstroms with modeled GBC SecM peptide | 分子名称: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Schulte, L, Reitz, J, Hodirnau, V.V, Kudlinzki, D, Mao, J, Glaubitz, C, Frangakis, A, Schwalbe, H. | 登録日 | 2019-01-03 | 公開日 | 2020-01-15 | 最終更新日 | 2020-12-02 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. Nat Commun, 11, 2020
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6TM0
| N-Domain P40/P90 Mycoplasma pneumoniae complexed with 6'SL | 分子名称: | Mgp-operon protein 3, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | 著者 | Vizarraga, D, Aparicio, D, Illanes, R, Fita, I, Perez-Luque, R, Martin, J. | 登録日 | 2019-12-03 | 公開日 | 2020-11-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae. Nat Commun, 11, 2020
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7BWM
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6RC9
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