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2YIX
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BU of 2yix by Molmil
Triazolopyridine Inhibitors of p38
分子名称: 1-ethyl-3-(2-{[3-(1-methylethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]sulfanyl}benzyl)urea, MITOGEN-ACTIVATED PROTEIN KINASE 14
著者Millan, D.S, Anderson, M, Bunnage, M.E, Burrows, J.L, Butcher, K.J, Dodd, P.G, Evans, T.J, Fairman, D.A, Han, s, Hughes, S.J, Irving, S.L, Kilty, I.C, Lemaitre, A, Lewthawaite, R.A, Mahke, A, Marr, E, Mathias, J.P, Philip, J, Phillips, C, Smith, R.T, Stefaniak, M.H, Yeadon, M.
登録日2011-05-17
公開日2011-11-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Design and Synthesis of Inhaled P38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease.
J.Med.Chem., 54, 2011
2YIW
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triazolopyridine inhibitors of p38 kinase
分子名称: 1-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-{[3-(1-methylethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]sulfanyl}benzyl)urea, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, MITOGEN-ACTIVATED PROTEIN KINASE 14
著者Millan, D.S, Anderson, M, Bunnage, M.E, Burrows, J.L, Butcher, K.J, Dodd, P.G, Evans, T.J, Fairman, D.A, Hughes, S.J, Irving, S.L, Kilty, I.C, Lemaitre, A, Lewthwaite, R.A, Mahnke, A, Mathais, J.P, Philip, J, Phillips, C, Smith, R.T, Stefamiak, M.H, Yeadon, M.
登録日2011-05-17
公開日2011-11-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Design and Synthesis of Inhaled P38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease.
J.Med.Chem., 54, 2011
2YIS
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BU of 2yis by Molmil
triazolopyridine inhibitors of p38 kinase.
分子名称: 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-{2-[(3-{2-[(2-hydroxyethyl)sulfanyl]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)sulfanyl]benzyl}urea, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, MITOGEN-ACTIVATED PROTEIN KINASE 14
著者Millan, D.S, Anderson, M, Bazin, R, Bunnage, M.E, Burrows, J.L, Butcher, K.J, Dodd, P.G, Evans, T.J, Fairman, D.A, Hughes, S.J, Irving, S.L, Kilty, I.C, Lemaitre, A, Lewthwaite, R.A, Mahnke, A, Mathais, J.P, Philip, J, Phillips, C, Smith, R.T, Stefaniack, M.H, Yeadon, M.
登録日2011-05-16
公開日2011-11-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Design and Synthesis of Inhaled P38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease.
J.Med.Chem., 54, 2011
2CE1
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BU of 2ce1 by Molmil
Structure of reduced Arabidopsis thaliana cytochrome 6A
分子名称: CYTOCHROME C6, HEME C
著者Marcaida, M.J, Schlarb-Ridley, B.G, Worrall, J.A.R, Wastl, J, Evans, T.J, Bendall, D.S, Luisi, B.F, Howe, C.J.
登録日2006-02-02
公開日2006-07-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of Cytochrome C(6A), a Novel Dithio-Cytochrome of Arabidopsis Thaliana, and its Reactivity with Plastocyanin: Implications for Function.
J.Mol.Biol., 360, 2006
2CE0
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BU of 2ce0 by Molmil
Structure of oxidized Arabidopsis thaliana cytochrome 6A
分子名称: CYTOCHROME C6, HEME C
著者Marcaida, M.J, Schlarb-Ridley, B.G, Worrall, J.A.R, Wastl, J, Evans, T.J, Bendall, D.S, Luisi, B.F, Howe, C.J.
登録日2006-02-01
公開日2006-07-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.24 Å)
主引用文献Structure of Cytochrome C(6A), a Novel Dithio-Cytochrome of Arabidopsis Thaliana, and its Reactivity with Plastocyanin: Implications for Function.
J.Mol.Biol., 360, 2006
4KK7
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BU of 4kk7 by Molmil
Structure of EccB1 from the type VII (ESX-1) secretion system of Mycobacterium tuberculosis.
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ESX-1 secretion system protein eccB1, GLYCEROL, ...
著者Korotkov, K.V, Evans, T.J.
登録日2013-05-05
公開日2013-06-19
最終更新日2016-03-23
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Bmc Struct.Biol., 16, 2016
4KV2
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BU of 4kv2 by Molmil
Ubiquitin-like domain of the mycobacterium tuberculosis type VII secretion system protein ECCD1
分子名称: ESX-1 secretion system protein eccD1
著者Korotkov, K.V, Evans, T.J.
登録日2013-05-22
公開日2014-04-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Bmc Struct.Biol., 16, 2016
4KV3
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BU of 4kv3 by Molmil
Ubiquitin-like domain of the Mycobacterium tuberculosis type VII secretion system protein EccD1 as maltose-binding protein fusion
分子名称: Chimera fusion protein of ESX-1 secretion system protein eccD1 and Maltose-binding periplasmic protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Korotkov, K.V, Evans, T.J.
登録日2013-05-22
公開日2014-04-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Bmc Struct.Biol., 16, 2016
4KG7
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BU of 4kg7 by Molmil
Structure of MycP3 protease from the type VII (ESX-3) secretion system.
分子名称: CHLORIDE ION, Peptidase S8 and S53, subtilisin, ...
著者Korotkov, K.V, Evans, T.J.
登録日2013-04-28
公開日2013-06-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis.
J.Struct.Biol., 184, 2013
4F3V
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BU of 4f3v by Molmil
Crystal structure of N-terminal domain of EccA1 ATPase from ESX-1 secretion system of Mycobacterium tuberculosis
分子名称: ESX-1 secretion system protein EccA1, SAMARIUM (III) ION, SULFATE ION
著者Korotkov, K.V, Evans, T.J.
登録日2012-05-09
公開日2012-06-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the N-terminal domain of EccA1 ATPase from the ESX-1 secretion system of Mycobacterium tuberculosis.
Proteins, 82, 2014
4FTF
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BU of 4ftf by Molmil
Structure of the Type II secretion system pilotin AspS from Vibrio cholerae
分子名称: ACETATE ION, Alternate secretin pathway subunit S (VC395_1821, VC1703), ...
著者Korotkov, K.V, Evans, T.J.
登録日2012-06-27
公開日2012-11-28
最終更新日2013-02-06
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Assembly of the Type II Secretion System such as Found in Vibrio cholerae Depends on the Novel Pilotin AspS.
Plos Pathog., 9, 2013
4HVL
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BU of 4hvl by Molmil
Structure of a serine protease MycP1, an essential component of the type VII (ESX-1) secretion system
分子名称: ACETATE ION, CHLORIDE ION, IMIDAZOLE, ...
著者Korotkov, K.V, Evans, T.J.
登録日2012-11-06
公開日2013-05-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis.
J.Struct.Biol., 184, 2013
5CYU
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BU of 5cyu by Molmil
Structure of the soluble domain of EccB1 from the Mycobacterium smegmatis ESX-1 secretion system.
分子名称: Conserved membrane protein
著者Arbing, M.A, Chan, S, Kahng, S, Kim, J, Eisenberg, D.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-07-30
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.07 Å)
主引用文献Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Bmc Struct.Biol., 16, 2016
5DLB
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BU of 5dlb by Molmil
Crystal structure of chaperone EspG3 of ESX-3 type VII secretion system from Mycobacterium marinum M
分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, GLYCEROL, PLATINUM (II) ION, ...
著者Chan, S, Arbing, M.A, Kim, J, Kahng, S, Sawaya, M.R, Eisenberg, D.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-09-04
公開日2015-09-23
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems.
J. Mol. Biol., 431, 2019
4XWP
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BU of 4xwp by Molmil
Structure of PE-PPE domains of ESX-1 secreted protein EspB, C2221 in presence of Ca
分子名称: CALCIUM ION, ESX-1 secretion-associated protein EspB
著者Korotkov, K.V.
登録日2015-01-28
公開日2015-02-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis.
J.Struct.Biol., 191, 2015
4XY3
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BU of 4xy3 by Molmil
Structure of ESX-1 secreted protein EspB
分子名称: ESX-1 secretion-associated protein EspB
著者Wagner, J.M, Korotkov, K.V.
登録日2015-02-01
公開日2015-02-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.04 Å)
主引用文献Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis.
J.Struct.Biol., 191, 2015
4XXN
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BU of 4xxn by Molmil
Structure of PE-PPE domains of ESX-1 secreted protein EspB, I222
分子名称: CHLORIDE ION, ESX-1 secretion-associated protein EspB, SODIUM ION
著者Korotkov, K.V.
登録日2015-01-30
公開日2015-02-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis.
J.Struct.Biol., 191, 2015
4XXX
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BU of 4xxx by Molmil
Structure of PE-PPE domains of ESX-1 secreted protein EspB, C2221
分子名称: CHLORIDE ION, ESX-1 secretion-associated protein EspB, GLYCEROL
著者Piton, J, Pojer, F, Korotkov, K.V.
登録日2015-01-30
公開日2015-02-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis.
J.Struct.Biol., 191, 2015
4RCL
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BU of 4rcl by Molmil
Structure of EspG3 chaperone from the type VII (ESX-3) secretion system, space group P43212
分子名称: ESPG3
著者Korotkov, K.V.
登録日2014-09-16
公開日2015-09-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems.
J. Mol. Biol., 431, 2019
4L4W
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BU of 4l4w by Molmil
Structure of EspG3 chaperone from the type VII (ESX-3) secretion system
分子名称: EspG3
著者Korotkov, K.V.
登録日2013-06-09
公開日2014-06-11
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.036 Å)
主引用文献Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems.
J. Mol. Biol., 431, 2019
4KXR
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BU of 4kxr by Molmil
Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer
分子名称: EspG5, PE25, PPE41
著者Korotkova, N, Creekmore, C.C, Korotkov, K.V.
登録日2013-05-27
公開日2014-05-28
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer.
Mol.Microbiol., 94, 2014
5SXL
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Structure of EspG3 chaperone from the type VII (ESX-3) secretion system, space group P3221
分子名称: ESX-3 secretion-associated protein EspG3
著者Korotkov, K.V.
登録日2016-08-09
公開日2016-08-24
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems.
J. Mol. Biol., 431, 2019
5VBA
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BU of 5vba by Molmil
Structure of EspG1 chaperone from the type VII (ESX-1) secretion system determined with the assistance of N-terminal T4 lysozyme fusion
分子名称: CHLORIDE ION, Lysozyme, ESX-1 secretion-associated protein EspG1 chimera
著者Korotkov, K.V.
登録日2017-03-29
公開日2017-07-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems.
J. Mol. Biol., 431, 2019

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