9G13
 
 | | VHH H3-2 in complex with Tau C-terminal peptide | | 分子名称: | Isoform Tau-F of Microtubule-associated protein tau, VHH H3-2 | | 著者 | Dupre, E, Landrieu, I, Danis, C, Hanoulle, X, Mortelecque, J. | | 登録日 | 2024-07-09 | | 公開日 | 2024-07-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | VHH H3-2 in complex with Tau C-terminal peptide
To Be Published
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4Q0C
 | | 3.1 A resolution crystal structure of the B. pertussis BvgS periplasmic domain | | 分子名称: | Virulence sensor protein BvgS | | 著者 | Dupre, E, Herrou, J, Lensink, M.F, Wintjens, R, Lebedev, A, Crosson, S, Villeret, V, Locht, C, Antoine, R, Jacob-Dubuisson, F. | | 登録日 | 2014-04-01 | | 公開日 | 2015-02-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Virulence Regulation with Venus Flytrap Domains: Structure and Function of the Periplasmic Moiety of the Sensor-Kinase BvgS.
Plos Pathog., 11, 2015
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7NTT
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7NTW
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6ZJ8
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7NTQ
 | | Crystal structure of the SARS-CoV-2 Main Protease complexed with N-(pyridin-3-ylmethyl)thioformamide | | 分子名称: | 3C-like proteinase, DIMETHYL SULFOXIDE, FORMIC ACID, ... | | 著者 | Dupre, E, Villeret, V, Hanoulle, X. | | 登録日 | 2021-03-10 | | 公開日 | 2022-03-02 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.495 Å) | | 主引用文献 | Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses.
Eur.J.Med.Chem., 250, 2023
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8OPI
 | | VHH Z70 mutant 1 in interaction with PHF6 Tau peptide | | 分子名称: | PHF6 Tau peptide, VHH Z70 mutant 1 | | 著者 | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | | 登録日 | 2023-04-07 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
J.Biol.Chem., 300, 2024
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8OP0
 | | VHH Z70 mutant 20 in interaction with PHF6 Tau peptide | | 分子名称: | Tau PHF6 peptide, VHH Z70 mutant 20 | | 著者 | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | | 登録日 | 2023-04-06 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
J.Biol.Chem., 300, 2024
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8PII
 | | VHH Z70 mutant 3 in interaction with PHF6 Tau peptide | | 分子名称: | Microtubule-associated protein tau, VHH Z70 Mutant 3 | | 著者 | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | | 登録日 | 2023-06-21 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
J.Biol.Chem., 300, 2024
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7NLC
 | | Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide | | 分子名称: | AMMONIUM ION, CHLORIDE ION, Protein ORF3, ... | | 著者 | Moschidi, D, Dupre, E, Villeret, V, Hanoulle, X. | | 登録日 | 2021-02-22 | | 公開日 | 2022-03-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.398 Å) | | 主引用文献 | Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide
To Be Published
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3MPK
 | | Crystal Structure of Bordetella pertussis BvgS periplasmic VFT2 domain | | 分子名称: | ACETATE ION, GLYCEROL, Virulence sensor protein bvgS | | 著者 | Herrou, J, Bompard, C, Wintjens, R, Dupre, E, Willery, E, Villeret, V, Locht, C, Antoine, R, Jacob-Dubuisson, F. | | 登録日 | 2010-04-27 | | 公開日 | 2010-10-06 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3MPL
 | | Crystal Structure of Bordetella pertussis BvgS VFT2 domain (Double Mutant F375E/Q461E) | | 分子名称: | 1,2-ETHANEDIOL, Virulence sensor protein bvgS | | 著者 | Herrou, J, Bompard, C, Wintjens, R, Dupre, E, Willery, E, Villeret, V, Locht, C, Antoine, R, Jacob-Dubuisson, F. | | 登録日 | 2010-04-27 | | 公開日 | 2010-10-06 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism.
Proc.Natl.Acad.Sci.USA, 107, 2010
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7QCQ
 | | VHH Z70 in interaction with PHF6 Tau peptide | | 分子名称: | GLYCEROL, Tau 301-312, VHH Z70 | | 著者 | Danis, C, Dupre, E, Zejneli, O, Caillierez, R, Arrial, A, Begard, S, Loyens, A, Mortelecque, J, Cantrelle, F.-X, Hanoulle, X, Rain, J.-C, Colin, M, Buee, L, Landrieu, I. | | 登録日 | 2021-11-25 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.
Mol.Ther., 30, 2022
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7NTS
 | | Crystal structure of the SARS-CoV-2 Main Protease with oxidized C145 | | 分子名称: | DIMETHYL SULFOXIDE, FORMIC ACID, GLYCEROL, ... | | 著者 | Dupre, E, Villeret, V, Hanoulle, X. | | 登録日 | 2021-03-10 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.477 Å) | | 主引用文献 | NMR Spectroscopy of the Main Protease of SARS-CoV-2 and Fragment-Based Screening Identify Three Protein Hotspots and an Antiviral Fragment.
Angew.Chem.Int.Ed.Engl., 60, 2021
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8AEB
 | | SARS-CoV-2 Main Protease complexed with N-(pyridin-3-ylmethyl)thioformamide | | 分子名称: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, N-(pyridin-3-ylmethyl)thioformamide, ... | | 著者 | Hanoulle, X, Charton, J, Deprez, B. | | 登録日 | 2022-07-12 | | 公開日 | 2023-03-15 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses.
Eur.J.Med.Chem., 250, 2023
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4QKY
 | | Crystal Structure Analysis of the Membrane Transporter FhaC | | 分子名称: | Filamentous hemagglutinin transporter protein FhaC, PHOSPHATE ION | | 著者 | Maier, T, Clantin, B, Gruss, F, Dewitte, F, Delattre, A.S, Jacob-Dubuisson, F, Hiller, S, Villeret, V. | | 登録日 | 2014-06-10 | | 公開日 | 2014-10-22 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Conserved Omp85 lid-lock structure and substrate recognition in FhaC
Nat Commun, 6, 2015
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