3JSU
| Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-chloro-N~6~-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine, Dihydrofolate reductase-thymidylate synthase, ... | 著者 | Chitnumsub, P, Maneeruttanarungroj, C, Kamchonwongpaisan, S, Yuthavong, Y, Diagana, T.T. | 登録日 | 2009-09-11 | 公開日 | 2010-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate Antimicrob.Agents Chemother., 54, 2010
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8VOF
| GI targeted CpPI4K inhibitor | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2 of Phosphatidylinositol 4-kinase beta,Isoform 2 of Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... | 著者 | Knapp, M.S, Cuellar, C, Mamo, M. | 登録日 | 2024-01-15 | 公開日 | 2024-09-04 | 最終更新日 | 2024-09-25 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis Nat Microbiol, 2024
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6Q2A
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4R9S
| Mycobacterium tuberculosis InhA bound to NITD-916 | 分子名称: | 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenylpyridin-2(1H)-one, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Noble, C.G. | 登録日 | 2014-09-07 | 公開日 | 2015-01-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Direct inhibitors of InhA are active against Mycobacterium tuberculosis Sci Transl Med, 7, 2015
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8GCC
| T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor CT1 | 分子名称: | 2-{3-[(Z)-iminomethyl]-1H-1,2,4-triazol-1-yl}-1-{(3M)-3-[2-(trifluoromethyl)phenyl]-6H-pyrrolo[3,4-b]pyridin-6-yl}ethan-1-one, DNA (28-MER), DNA topoisomerase 2 | 著者 | Schenk, A, Deniston, C, Noeske, J. | 登録日 | 2023-03-01 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380, 2023
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4R9R
| Mycobacterium tuberculosis InhA bound to NITD-564 | 分子名称: | 6-(cyclohexylmethyl)-4-hydroxy-3-phenylpyridin-2(1H)-one, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Noble, C.G. | 登録日 | 2014-09-07 | 公開日 | 2015-01-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Direct inhibitors of InhA are active against Mycobacterium tuberculosis Sci Transl Med, 7, 2015
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7ZYJ
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