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1M7W
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BU of 1m7w by Molmil
HNF4a ligand binding domain with bound fatty acid
分子名称: Hepatocyte nuclear factor 4-alpha, LAURIC ACID
著者Dhe-Paganon, S, Duda, K, Iwamoto, M, Chi, Y.I, Shoelson, S.E.
登録日2002-07-22
公開日2003-07-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand
J.Biol.Chem., 277, 2002
1EKG
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BU of 1ekg by Molmil
MATURE HUMAN FRATAXIN
分子名称: FRATAXIN
著者Dhe-Paganon, S, Shigeta, R, Chi, Y.I, Ristow, M, Shoelson, S.E.
登録日2000-03-08
公開日2000-11-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of human frataxin.
J.Biol.Chem., 275, 2000
1IFR
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BU of 1ifr by Molmil
Structure of Lamin A/C Globular Domain
分子名称: GLYCEROL, Lamin A/C
著者Dhe-Paganon, S, Werner, E.D, Shoelson, S.E.
登録日2001-04-13
公開日2002-07-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of the globular tail of nuclear lamin.
J.Biol.Chem., 277, 2002
1QQG
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BU of 1qqg by Molmil
CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1
分子名称: INSULIN RECEPTOR SUBSTRATE 1
著者Dhe-Paganon, S, Shoelson, S.E.
登録日1999-06-04
公開日1999-08-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Proc.Natl.Acad.Sci.USA, 96, 1999
1Q2H
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BU of 1q2h by Molmil
Phenylalanine Zipper Mediates APS Dimerization
分子名称: adaptor protein with pleckstrin homology and src homology 2 domains
著者Dhe-Paganon, S, Werner, E.D, Nishi, M, Chi, Y.-I, Shoelson, S.E.
登録日2003-07-24
公開日2004-08-03
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A phenylalanine zipper mediates APS dimerization.
Nat.Struct.Mol.Biol., 11, 2004
6MBZ
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BU of 6mbz by Molmil
Structure of Transcription Factor
分子名称: Signal transducer and activator of transcription 5B
著者Seo, H.-S, Dhe-Paganon, S.
登録日2018-08-30
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Structural and functional consequences of the STAT5BN642Hdriver mutation.
Nat Commun, 10, 2019
7MKX
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BU of 7mkx by Molmil
Crystal Structure Analysis of human CDK2 and CCNA2 complex
分子名称: 2-[(5-bromo-2-{4-[(cyanomethyl)sulfamoyl]anilino}pyrimidin-4-yl)amino]-6-fluorobenzamide, Cyclin-A2, Cyclin-dependent kinase 2
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-04-27
公開日2022-11-09
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Crystal Structure Analysis of human CDK2 and CCNA2 complex
To Be Published
3S8I
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BU of 3s8i by Molmil
The retroviral-like protease (RVP) domain of human DDI1
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ...
著者Walker, J.R, Asinas, A, Dong, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2011-05-28
公開日2011-07-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Retropepsin-Like Domain of Human DDI1
To be Published
2IBI
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BU of 2ibi by Molmil
Covalent Ubiquitin-USP2 Complex
分子名称: ETHANAMINE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 2, ...
著者Walker, J.R, Avvakumov, G.V, Bernstein, G, Xue, S, Finerty Jr, P.J, MacKenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2006-09-11
公開日2006-10-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Covalent Ubiquitin-USP2 Complex
To be Published
3CLZ
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BU of 3clz by Molmil
The set and ring associated (SRA) domain of UHRF1 bound to methylated DNA
分子名称: 5'-D(*DCP*DCP*DCP*DTP*DGP*DCP*DGP*DGP*DGP*DCP*DCP*DC)-3', 5'-D(*DGP*DGP*DGP*DCP*DCP*(5CM)P*DGP*DCP*DAP*DGP*DGP*DG)-3', E3 ubiquitin-protein ligase UHRF1
著者Walker, J.R, Avvakumov, G.V, Xue, S, Dong, A, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2008-03-20
公開日2008-04-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.
Nature, 455, 2008
3DB4
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BU of 3db4 by Molmil
Crystal structure of the tandem tudor domains of the E3 ubiquitin-protein ligase UHRF1
分子名称: E3 ubiquitin-protein ligase UHRF1, SULFATE ION
著者Walker, J.R, Avvakumov, G.V, Xue, S, Dong, A, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2008-05-30
公開日2008-09-16
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.
J.Biol.Chem., 286, 2011
3CEG
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BU of 3ceg by Molmil
Crystal structure of the UBC domain of baculoviral IAP repeat-containing protein 6
分子名称: Baculoviral IAP repeat-containing protein 6
著者Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2008-02-29
公開日2008-04-01
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.008 Å)
主引用文献A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
Mol Cell Proteomics, 11, 2012
8CUC
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BU of 8cuc by Molmil
Crystal structure analysis of SALL4 zinc finger domain in complex with DNA
分子名称: DNA (5'-D(P*CP*GP*AP*AP*AP*TP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*TP*AP*TP*TP*TP*CP*G)-3'), Sal-like protein 4, ...
著者Seo, H.S, Dhe-Paganon, S.
登録日2022-05-17
公開日2023-05-24
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Crystal Structure Analysis of SALL4 Zinc Finger domain in complex with DNA
To Be Published
6DUN
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BU of 6dun by Molmil
Crystal Structure Analysis of PIN1
分子名称: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, TRIHYDROXYARSENITE(III)
著者Seo, H.-S, Dhe-Paganon, S.
登録日2018-06-21
公開日2019-03-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.
Nat Commun, 9, 2018
2I7A
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BU of 2i7a by Molmil
Domain IV of Human Calpain 13
分子名称: CALCIUM ION, Calpain 13, GLYCEROL, ...
著者Walker, J.R, Ng, K, Davis, T.L, Ravulapalli, R, Butler-cole, C, Finerty Jr, P.J, Newman, E.M, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2006-08-30
公開日2006-09-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of Human Calpain 13
To be Published
8ECM
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BU of 8ecm by Molmil
Crystal Structure Analysis of Acetyl-CoA acetyltransferase from Firmicutes bacterium
分子名称: Acetyl-CoA acetyltransferase
著者Seo, H.S, Dhe-Paganon, S.
登録日2022-09-02
公開日2023-05-31
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease.
Nat Med, 29, 2023
8EBK
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BU of 8ebk by Molmil
Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog
分子名称: ACE-LEU-THR-PHE-0EH-GLU-TYR-TRP-ALA-GLN-LEU-MK8-SER-ALA-ALA, HDMX
著者Seo, H.-S, Dhe-Paganon, S.
登録日2022-08-31
公開日2023-10-04
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog
To Be Published
8TLO
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BU of 8tlo by Molmil
Crystal Structure Analysis of BCL11A in complex with DNA
分子名称: B-cell lymphoma/leukemia 11A, DNA (5'-D(P*CP*GP*AP*CP*CP*GP*CP*AP*TP*TP*GP*GP*TP*CP*AP*AP*GP*CP*G)-3'), DNA (5'-D(P*GP*CP*TP*TP*GP*AP*CP*CP*AP*AP*TP*GP*CP*GP*GP*TP*CP*GP*C)-3'), ...
著者Seo, H.-S, Dhe-Paganon, S.
登録日2023-07-27
公開日2024-08-14
最終更新日2024-12-18
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6.
Structure, 32, 2024
4WJL
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BU of 4wjl by Molmil
Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Inactive dipeptidyl peptidase 10, ...
著者Bezerra, G.A, Dobrovetsky, E, Seitova, A, Fedosyuk, S, Dhe-Paganon, S, Gruber, K.
登録日2014-09-30
公開日2015-03-18
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels.
Sci Rep, 5, 2015
4WVL
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BU of 4wvl by Molmil
Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Histone-lysine N-methyltransferase, ...
著者Xu, X, Dhe-Paganon, S, Blacklow, S.
登録日2014-11-06
公開日2014-12-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement.
Acs Chem.Biol., 10, 2015
6MBW
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Structure of Transcription Factor
分子名称: Signal transducer and activator of transcription 5B
著者Seo, H.-S, Dhe-Paganon, S.
登録日2018-08-30
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.29 Å)
主引用文献Structural and functional consequences of the STAT5BN642H driver mutation.
Nat Commun, 10, 2019
5JWM
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BU of 5jwm by Molmil
Bivalent BET Bromodomain Inhibition
分子名称: 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]ethanamide, Bromodomain-containing protein 4
著者Seo, H.-S, Dhe-Paganon, S.
登録日2016-05-12
公開日2016-07-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Design and characterization of bivalent BET inhibitors.
Nat.Chem.Biol., 12, 2016
7KMR
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BU of 7kmr by Molmil
Crystal structure analysis of human KRAS mutant
分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas
著者Seo, H.-S, Dhe-Paganon, S.
登録日2020-11-03
公開日2021-11-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022
5K5F
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BU of 5k5f by Molmil
NMR structure of the HLTF HIRAN domain
分子名称: Helicase-like transcription factor
著者Bezsonova, I, Neculai, D, Korzhnev, D, Weigelt, J, Bountra, C, Edwards, A, Arrowsmith, C, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2016-05-23
公開日2016-06-08
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献NMR structure of the HLTF HIRAN domain
To Be Published
7LI5
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BU of 7li5 by Molmil
Crystal Structure Analysis of human TEAD1
分子名称: 1-[(3R,4R)-3-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]-4-{[4-(trifluoromethyl)phenyl]methoxy}pyrrolidin-1-yl]prop-2-en-1-one, SULFATE ION, Transcriptional enhancer factor TEF-1
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-01-26
公開日2022-02-02
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Crystal Structure Analysis of human TEAD1
To Be Published

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件を2025-07-09に公開中

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