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3DG8
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BU of 3dg8 by Molmil
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide, ...
著者Dasgupta, T, Chitnumsub, P, Maneeruttanarungroj, C, Kamchonwongpaisan, S, Nichols, S, Lyons, T.M, Tirado-Rives, J, Jorgensen, W.L, Yuthavong, Y, Anderson, K.S.
登録日2008-06-13
公開日2009-01-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria.
Acs Chem.Biol., 4, 2009
3DGA
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BU of 3dga by Molmil
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide, ...
著者Dasgupta, T, Chitnumsub, P, Maneeruttanarungroj, C, Kamchonwongpaisan, S, Nichols, S, Lyons, T.M, Tirado-Rives, J, Jorgensen, W.L, Yuthavong, Y, Anderson, K.S.
登録日2008-06-13
公開日2009-01-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria.
Acs Chem.Biol., 4, 2009
6JTZ
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BU of 6jtz by Molmil
Crystal Structure of hRecQ1_D2-Zn-WH containing mutation on beta-hairpin
分子名称: ATP-dependent DNA helicase Q1, ZINC ION
著者Das, T, Mukhopadhyay, S, Bose, M, Das, A.K, Ganguly, A.
登録日2019-04-12
公開日2020-04-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.797 Å)
主引用文献Residues at the interface between zinc binding and winged helix domains of human RECQ1 play a significant role in DNA strand annealing activity.
Nucleic Acids Res., 2021
8ENJ
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BU of 8enj by Molmil
Design, synthesis, biological evaluation, and X-ray crystallography of diarylpyrazole derivatives possessing terminal arylsulfonamide moieties as anti-proliferative agents targeting c-Jun N-terminal kinase (JNK)
分子名称: Mitogen-activated protein kinase 10, N-[3-({(4P)-4-[(3M)-1-tert-butyl-3-(3-hydroxyphenyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)propyl]-4-hydroxybenzene-1-sulfonamide
著者Park, H, Mersal, K.I.
登録日2022-09-30
公開日2023-10-18
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.
Eur.J.Med.Chem., 261, 2023
5CTT
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BU of 5ctt by Molmil
Crystal structure of human SART3/TIP110 NLS-mouse importin alpha complex
分子名称: Importin subunit alpha-1, Squamous cell carcinoma antigen recognized by T-cells 3
著者Park, J.K, Kim, E.E.
登録日2015-07-24
公開日2016-04-27
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3
Nucleic Acids Res., 44, 2016
5CTQ
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BU of 5ctq by Molmil
Crystal structure of human SART3/TIP110 half-a TPR (HAT) domain
分子名称: Squamous cell carcinoma antigen recognized by T-cells 3
著者Park, J.K, Kim, E.E.
登録日2015-07-24
公開日2016-04-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3
Nucleic Acids Res., 44, 2016
5CTR
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BU of 5ctr by Molmil
Crystal structure of human SART3 HAT-C domain-human USP4 DUSP-UBL domain complex
分子名称: Squamous cell carcinoma antigen recognized by T-cells 3, Ubiquitin carboxyl-terminal hydrolase 4
著者Park, J.K, Kim, E.E.
登録日2015-07-24
公開日2016-04-27
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.012 Å)
主引用文献Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3
Nucleic Acids Res., 44, 2016
8CZQ
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BU of 8czq by Molmil
The crystal structure of MtbTOP1 in complex with both G- and T-segments
分子名称: ACETATE ION, DNA (5'-D(*CP*TP*TP*CP*CP*GP*CP*TP*TP*GP*AP*C)-3'), DNA topoisomerase 1, ...
著者Tan, K, Tse-Dinh, Y.-C.
登録日2022-05-25
公開日2022-12-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献The interaction between transport-segment DNA and topoisomerase IA-crystal structure of MtbTOP1 in complex with both G- and T-segments.
Nucleic Acids Res., 51, 2023
1EIZ
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BU of 1eiz by Molmil
FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE
分子名称: FTSJ, S-ADENOSYLMETHIONINE
著者Bugl, H, Fauman, E.B, Staker, B.L, Zheng, F, Kushner, S.R, Saper, M.A, Bardwell, J.C.A, Jakob, U.
登録日2000-02-29
公開日2000-08-30
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献RNA methylation under heat shock control.
Mol.Cell, 6, 2000
1EJ0
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BU of 1ej0 by Molmil
FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE, MERCURY DERIVATIVE
分子名称: FTSJ, MERCURY (II) ION, S-ADENOSYLMETHIONINE
著者Bugl, H, Fauman, E.B, Staker, B.L, Zheng, F, Kushner, S.R, Saper, M.A, Bardwell, J.C.A, Jakob, U.
登録日2000-02-29
公開日2000-08-30
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献RNA methylation under heat shock control.
Mol.Cell, 6, 2000

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件を2024-08-07に公開中

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