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8SP7
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BU of 8sp7 by Molmil
LINE-1 retrotransposon endonuclease domain complex with tranexamic acid
分子名称: LINE-1 retrotransposon endonuclease, SULFATE ION, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID
著者D'Ordine, A.M, Jogl, G, Sedivy, J.M.
登録日2023-05-02
公開日2024-05-22
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease.
Nat Commun, 15, 2024
8SP5
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BU of 8sp5 by Molmil
LINE-1 retrotransposon endonuclease domain complex with Mn2+
分子名称: LINE-1 retrotransposon endonuclease, MANGANESE (II) ION, SULFATE ION
著者D'Ordine, A.M, Jogl, G, Sedivy, J.M.
登録日2023-05-02
公開日2024-05-22
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease.
Nat Commun, 15, 2024
7MPZ
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BU of 7mpz by Molmil
HNH Nuclease Domain from G. stearothermophilus Cas9
分子名称: CRISPR-associated endonuclease Cas9
著者D'Ordine, A.M, Belato, H.B, Lisi, G.P, Jogl, G.
登録日2021-05-05
公開日2021-12-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structural and dynamic insights into the HNH nuclease of divergent Cas9 species.
J.Struct.Biol., 214, 2021
8F43
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HNH Nuclease Domain from G. stearothermophilus Cas9, K597A mutant
分子名称: CRISPR-associated endonuclease Cas9
著者D'Ordine, A.M, Belato, H.B, Lisi, G.P, Jogl, G.
登録日2022-11-10
公開日2022-12-21
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Disruption of electrostatic contacts in the HNH nuclease from a thermophilic Cas9 rewires allosteric motions and enhances high-temperature DNA cleavage.
J.Chem.Phys., 157, 2022
8SCA
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BU of 8sca by Molmil
Rec3 Domain from S. pyogenes Cas9
分子名称: 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9/Csn1
著者D'Ordine, A.M, Skeens, E, Lisi, G.P, Jogl, G.
登録日2023-04-05
公開日2024-03-13
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献High-fidelity, hyper-accurate, and evolved mutants rewire atomic-level communication in CRISPR-Cas9.
Sci Adv, 10, 2024

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件を2024-06-26に公開中

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