1FF3
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![BU of 1ff3 by Molmil](/molmil-images/mine/1ff3) | STRUCTURE OF THE PEPTIDE METHIONINE SULFOXIDE REDUCTASE FROM ESCHERICHIA COLI | 分子名称: | PEPTIDE METHIONINE SULFOXIDE REDUCTASE, SULFATE ION | 著者 | Tete-Favier, F, Cobessi, D, Boschi-Muller, S, Azza, S, Branlant, G, Aubry, A. | 登録日 | 2000-07-25 | 公開日 | 2000-12-06 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the Escherichia coli peptide methionine sulphoxide reductase at 1.9 A resolution. Structure Fold.Des., 8, 2000
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3U11
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![BU of 3u11 by Molmil](/molmil-images/mine/3u11) | Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 著者 | Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A. | 登録日 | 2011-09-29 | 公開日 | 2011-10-26 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J.Biol.Chem., 286, 2011
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3U10
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![BU of 3u10 by Molmil](/molmil-images/mine/3u10) | Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | 著者 | Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A. | 登録日 | 2011-09-29 | 公開日 | 2011-10-26 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J.Biol.Chem., 286, 2011
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3U0Z
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![BU of 3u0z by Molmil](/molmil-images/mine/3u0z) | Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 著者 | Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A. | 登録日 | 2011-09-29 | 公開日 | 2011-10-26 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J.Biol.Chem., 286, 2011
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3JPV
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![BU of 3jpv by Molmil](/molmil-images/mine/3jpv) | Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a pyrrolo[2,3-a]carbazole ligand | 分子名称: | 1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde, Peptide (PIMTIDE) ARKRRRHPSGPPTA, Proto-oncogene serine/threonine-protein kinase Pim-1 | 著者 | Filippakopoulos, P, Bullock, A.N, Fedorov, O, Akue-Gedu, R, Rossignol, E, Azzaro, S, Bain, J, Cohen, P, Prudhomme, M, Moreau, P, Amizon, F, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2009-09-04 | 公開日 | 2009-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new pim kinase inhibitors. J.Med.Chem., 52, 2009
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8SSZ
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![BU of 8ssz by Molmil](/molmil-images/mine/8ssz) | |
8ST3
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![BU of 8st3 by Molmil](/molmil-images/mine/8st3) | |
8ST0
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![BU of 8st0 by Molmil](/molmil-images/mine/8st0) | |
8ST1
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![BU of 8st1 by Molmil](/molmil-images/mine/8st1) | |
8ST2
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![BU of 8st2 by Molmil](/molmil-images/mine/8st2) | |
8ST4
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![BU of 8st4 by Molmil](/molmil-images/mine/8st4) | |
2EUH
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![BU of 2euh by Molmil](/molmil-images/mine/2euh) | HOLO FORM OF A NADP DEPENDENT ALDEHYDE DEHYDROGENASE COMPLEX WITH NADP+ | 分子名称: | NADP DEPENDENT NON PHOSPHORYLATING GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION | 著者 | Cobessi, D, Tete-Favier, F, Marchal, S, Branlant, G, Aubry, A. | 登録日 | 1998-11-05 | 公開日 | 1999-07-22 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Apo and holo crystal structures of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans. J.Mol.Biol., 290, 1999
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1EUH
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![BU of 1euh by Molmil](/molmil-images/mine/1euh) | APO FORM OF A NADP DEPENDENT ALDEHYDE DEHYDROGENASE FROM STREPTOCOCCUS MUTANS | 分子名称: | NADP DEPENDENT NON PHOSPHORYLATING GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, SULFATE ION | 著者 | Cobessi, D, Tete-Favier, F, Marchal, S, Branlant, G, Aubry, A. | 登録日 | 1998-11-05 | 公開日 | 1999-07-22 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Apo and holo crystal structures of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans. J.Mol.Biol., 290, 1999
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4WCD
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![BU of 4wcd by Molmil](/molmil-images/mine/4wcd) | Trypanosoma brucei PTR1 in complex with inhibitor 10 | 分子名称: | 5-(1H-benzotriazol-6-yl)-1,3,4-thiadiazol-2-amine, ACETATE ION, GLYCEROL, ... | 著者 | Mangani, S, Di Pisa, F, Pozzi, C. | 登録日 | 2014-09-04 | 公開日 | 2015-09-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ACS Omega, 2, 2017
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4WCF
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![BU of 4wcf by Molmil](/molmil-images/mine/4wcf) | Trypanosoma brucei PTR1 in complex with inhibitor 9 | 分子名称: | 3-(5-amino-1,3,4-thiadiazol-2-yl)pyridin-4-amine, ACETATE ION, GLYCEROL, ... | 著者 | Mangani, S, Di Pisa, F, Pozzi, C. | 登録日 | 2014-09-04 | 公開日 | 2015-09-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ACS Omega, 2, 2017
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5IZC
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![BU of 5izc by Molmil](/molmil-images/mine/5izc) | Trypanosoma brucei PTR1 in complex with inhibitor F032 | 分子名称: | ACETATE ION, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Pozzi, C, Landi, G, Di Pisa, F, Mangani, S. | 登録日 | 2016-03-25 | 公開日 | 2017-04-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ACS Omega, 2, 2017
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2YHI
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![BU of 2yhi by Molmil](/molmil-images/mine/2yhi) | Trypanosoma brucei PTR1 in complex with inhibitor WH16 | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... | 著者 | Nerini, E, Dawson, A, Hunter, W.N, Costi, M.P. | 登録日 | 2011-05-03 | 公開日 | 2012-05-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ACS Omega, 2, 2017
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2YHU
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![BU of 2yhu by Molmil](/molmil-images/mine/2yhu) | Trypanosoma brucei PTR1 in complex with inhibitor WHF30 | 分子名称: | 3-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1-THIOPHEN-2-YLPROPAN-1-ONE, ACETATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Nerini, E, Dawson, A, Hunter, W.N, Costi, M.P. | 登録日 | 2011-05-06 | 公開日 | 2012-05-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ACS Omega, 2, 2017
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5KCX
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![BU of 5kcx by Molmil](/molmil-images/mine/5kcx) | Pim-1 kinase in Complex with a Selective N-substituted 7-azaindole Inhibitor | 分子名称: | 4-chloranyl-1-methyl-2-[4-(4-methylpiperazin-1-yl)phenyl]pyrrolo[2,3-b]pyridine-6-carboxamide, ACETATE ION, IMIDAZOLE, ... | 著者 | Mechin, I, McLean, L.R, Zhang, Y, Wang, R. | 登録日 | 2016-06-07 | 公開日 | 2017-07-19 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I. Bioorg. Med. Chem. Lett., 27, 2017
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2RGP
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![BU of 2rgp by Molmil](/molmil-images/mine/2rgp) | Structure of EGFR in complex with hydrazone, a potent dual inhibitor | 分子名称: | Epidermal growth factor receptor, N-[1-(3-fluorobenzyl)-1H-indazol-5-yl]-5-[(piperidin-1-ylamino)methyl]pyrimidine-4,6-diamine, PHOSPHATE ION | 著者 | Abad, M.C. | 登録日 | 2007-10-04 | 公開日 | 2008-08-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
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8USS
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![BU of 8uss by Molmil](/molmil-images/mine/8uss) | IL17A complexed to Compound 7 | 分子名称: | 4,5-dichloro-N-[(1S)-1-cyclohexyl-2-{[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]amino}-2-oxoethyl]-1H-pyrrole-2-carboxamide, CHLORIDE ION, Interleukin-17A | 著者 | Argiriadi, M.A, Ramos, A.L. | 登録日 | 2023-10-29 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds. J.Med.Chem., 67, 2024
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8USR
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![BU of 8usr by Molmil](/molmil-images/mine/8usr) | IL17A homodimer complexed to Compound 23 | 分子名称: | Interleukin-17A, ~{N}-[(2~{S})-1-[[(1~{S})-1-(8~{a}~{H}-imidazo[1,2-a]pyrimidin-2-yl)ethyl]amino]-1-oxidanylidene-4-phenyl-butan-2-yl]-4,5-bis(chloranyl)-1~{H}-pyrrole-2-carboxamide | 著者 | Argiriadi, M.A, Ramos, A.L. | 登録日 | 2023-10-29 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds. J.Med.Chem., 67, 2024
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5TOE
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![BU of 5toe by Molmil](/molmil-images/mine/5toe) | Pim-1 kinase in complex with a 7-azaindole | 分子名称: | 2-[4-(piperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile, Serine/threonine-protein kinase pim-1 | 著者 | Mclean, L, Mechin, I, Zhang, Y, Wang, R, Batchelor, J.D. | 登録日 | 2016-10-17 | 公開日 | 2017-10-11 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | 主引用文献 | Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I. Bioorg. Med. Chem. Lett., 27, 2017
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5TEX
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![BU of 5tex by Molmil](/molmil-images/mine/5tex) | Pim-1 kinase in complex with a 7-azaindole | 分子名称: | (4-{4-chloro-1-methyl-2-[4-(piperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)methanol, IMIDAZOLE, Serine/threonine-protein kinase pim-1 | 著者 | Mechin, I, Wang, R, Batchelor, J.D, McLean, L. | 登録日 | 2016-09-23 | 公開日 | 2017-10-11 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.149 Å) | 主引用文献 | Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I. Bioorg. Med. Chem. Lett., 27, 2017
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5TUR
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![BU of 5tur by Molmil](/molmil-images/mine/5tur) | Pim-1 kinase in complex with a 7-azaindole | 分子名称: | 1-methyl-2-[4-(piperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile, Serine/threonine-protein kinase pim-1 | 著者 | Mechin, I, Zhang, Y, Wang, R, Batchelor, J.D, Mclean, L. | 登録日 | 2016-11-07 | 公開日 | 2017-10-11 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.948 Å) | 主引用文献 | Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I. Bioorg. Med. Chem. Lett., 27, 2017
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