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2X9C
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BU of 2x9c by Molmil
Crystal structure of a soluble PrgI mutant from Salmonella Typhimurium
分子名称: PROTEIN PRGI
著者Poyraz, O, Schmidt, H, Seidel, K, Delissen, F, Ader, C, Tenenboim, H, Goosmann, C, Laube, B, Thuenemann, A.F, Zychlinsky, A, Baldus, M, Lange, A, Griesinger, C, Kolbe, M.
登録日2010-03-15
公開日2010-06-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Protein Refolding is Required for Assembly of the Type Three Secretion Needle
Nat.Struct.Mol.Biol., 17, 2010
2KV7
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BU of 2kv7 by Molmil
NMR solution structure of a soluble PrgI mutant from Salmonella Typhimurium
分子名称: Protein prgI
著者Schmidt, H, Poyraz, O, Seidel, K, Delissen, F, Ader, C, Tenenboim, H, Goosmann, C, Laube, B, Thuenemann, A.F, Zychlinski, A, Baldus, M, Lange, A, Griesinger, C, Kolbe, M.
登録日2010-03-09
公開日2010-06-16
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Protein refolding is required for assembly of the type three secretion needle.
Nat.Struct.Mol.Biol., 17, 2010
6EI9
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BU of 6ei9 by Molmil
Crystal structure of E. coli tRNA-dihydrouridine synthase B (DusB)
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Bou-Nader, C, Hamdane, D.
登録日2017-09-18
公開日2018-01-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Unveiling structural and functional divergences of bacterial tRNA dihydrouridine synthases: perspectives on the evolution scenario.
Nucleic Acids Res., 46, 2018
6EZB
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BU of 6ezb by Molmil
Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain Q305K mutant
分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, SULFATE ION, ...
著者Bou-Nader, C, Bregeon, D, Pecqueur, L, Fontecave, M, Hamdane, D.
登録日2017-11-14
公開日2018-09-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
6EZA
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BU of 6eza by Molmil
Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K mutant
分子名称: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Bou-Nader, C, Bregeon, D, Pecqueur, L, Vincent, G, Fontecave, M, Hamdane, D.
登録日2017-11-14
公開日2018-09-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
4WFS
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BU of 4wfs by Molmil
Crystal Structure of tRNA-dihydrouridine(20) synthase catalytic domain
分子名称: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, SULFATE ION, ...
著者Bou-Nader, C, Pecqueur, L, Kamah, A, Bregeon, D, Golinelli-Pimpaneau, B, Guimaraes, B.G, Fontecave, M, Hamdane, D.
登録日2014-09-17
公開日2015-10-07
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献An extended dsRBD is required for post-transcriptional modification in human tRNAs.
Nucleic Acids Res., 43, 2015
4WFT
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BU of 4wft by Molmil
Crystal structure of tRNA-dihydrouridine(20) synthase dsRBD domain
分子名称: tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
著者Bou-Nader, C, Pecqueur, L, Kamah, A, Bregeon, D, Golinelli-Pimpaneau, B, Guimaraes, B.G, Fontecave, M, Hamdane, D.
登録日2014-09-17
公開日2015-10-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献An extended dsRBD is required for post-transcriptional modification in human tRNAs.
Nucleic Acids Res., 43, 2015
6OL3
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BU of 6ol3 by Molmil
Crystal structure of an adenovirus virus-associated RNA
分子名称: Adenovirus Virus-Associated (VA) RNA I apical and central domains, POTASSIUM ION
著者Hood, I.V, Gordon, J.M, Bou-Nader, C, Henderson, F.V, Bahmanjah, S, Zhang, J.
登録日2019-04-15
公開日2019-07-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Crystal structure of an adenovirus virus-associated RNA.
Nat Commun, 10, 2019
6EI8
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BU of 6ei8 by Molmil
Crystal structure of human tRNA-dihydrouridine (20) synthase dsRBD F359A mutant
分子名称: SULFATE ION, tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
著者Bou-Nader, C, Pecqueur, L, Hamdane, D.
登録日2017-09-18
公開日2018-10-10
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Conformational Stability Adaptation of a Double-Stranded RNA-Binding Domain to Transfer RNA Ligand.
Biochemistry, 58, 2019
7MRL
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BU of 7mrl by Molmil
Structure of HIV-1 matrix domain bound to human tRNALys3
分子名称: HIV-1 matrix domain, MAGNESIUM ION, tRNA Lys3
著者Bou-Nader, C, Zhang, J.
登録日2021-05-07
公開日2021-08-11
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization.
Cell Host Microbe, 29, 2021
7TQA
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BU of 7tqa by Molmil
Crystal Structure of monoclonal S9.6 Fab
分子名称: Fab S9.6 heavy chain, Fab S9.6 light chain, GLYCEROL, ...
著者Bou-Nader, C, Zhang, J.
登録日2022-01-26
公開日2022-03-30
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.328 Å)
主引用文献Structural basis of R-loop recognition by the S9.6 monoclonal antibody.
Nat Commun, 13, 2022
7TQB
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BU of 7tqb by Molmil
Crystal structure of monoclonal S9.6 Fab bound to DNA-RNA hybrid
分子名称: DNA, FAB S9.6 Heavy Chain, FAB S9.6 Light Chain, ...
著者Bou-Nader, C, Zhang, J.
登録日2022-01-26
公開日2022-03-30
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis of R-loop recognition by the S9.6 monoclonal antibody.
Nat Commun, 13, 2022
6BA5
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BU of 6ba5 by Molmil
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain Heavy chain, antibody R11, ...
著者Park, H, Rader, C.
登録日2017-10-12
公開日2018-06-13
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BAN
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BU of 6ban by Molmil
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain R11 Heavy chain, Variable domain of R11 Light Chain
著者Park, H, Rader, C.
登録日2017-10-14
公開日2018-06-13
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5OC6
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BU of 5oc6 by Molmil
Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD in complex with a 22 nucleotide dsRNA
分子名称: RNA, tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
著者Bou-nader, C, Pecqueur, L, Hamdane, D.
登録日2017-06-29
公開日2018-12-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.
Nucleic Acids Res., 47, 2019
5OC5
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BU of 5oc5 by Molmil
Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD K419A-K420A mutant
分子名称: CHLORIDE ION, GLYCEROL, tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
著者Bou-nader, C, Pecqueur, L, Hamdane, D.
登録日2017-06-29
公開日2018-12-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.893 Å)
主引用文献Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.
Nucleic Acids Res., 47, 2019
7NDZ
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BU of 7ndz by Molmil
ThyX reconstituted with N5-carbinolamine flavin
分子名称: DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent thymidylate synthase, ...
著者Bou-Nader, C, Pecqueur, L, Hamdane, D.
登録日2021-02-02
公開日2021-07-21
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献An enzymatic activation of formaldehyde for nucleotide methylation.
Nat Commun, 12, 2021
5OC4
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BU of 5oc4 by Molmil
Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD R361A-R362A mutant
分子名称: CACODYLATE ION, CHLORIDE ION, GLYCEROL, ...
著者Bou-nader, C, Pecqueur, L, Hamdane, D.
登録日2017-06-29
公開日2018-12-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.
Nucleic Acids Res., 47, 2019
7NDW
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BU of 7ndw by Molmil
ThyX-FADH2 soaked with 20 mM Formaldehyde
分子名称: DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent thymidylate synthase, ...
著者Bou-Nader, C, Pecqueur, L, Hamdane, D.
登録日2021-02-02
公開日2021-07-21
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An enzymatic activation of formaldehyde for nucleotide methylation.
Nat Commun, 12, 2021
5NL1
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BU of 5nl1 by Molmil
Shigella IpaA-VBS3/TBS in complex with the Talin VBS1 domain 488-512
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Invasin IpaA, ...
著者Bou-Nader, C, Pecqueur, L, Valencia-Gallardo, C, Fontecave, M, Tran Van Nhieu, G.
登録日2017-04-03
公開日2018-05-16
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Shigella IpaA Binding to Talin Stimulates Filopodial Capture and Cell Adhesion.
Cell Rep, 26, 2019
6EZC
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BU of 6ezc by Molmil
Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K Q305K double mutant
分子名称: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Bou-Nader, C, Bregeon, D, Vincent, G, Fontecave, M, Hamdane, D.
登録日2017-11-14
公開日2018-09-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
6OSV
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BU of 6osv by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
分子名称: Antibody heavy chain variable region, Antibody light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
著者Park, H, Rader, C.
登録日2019-05-02
公開日2020-04-01
最終更新日2020-05-13
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSN
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BU of 6osn by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
分子名称: ACETATE ION, Tyrosine-protein kinase transmembrane receptor ROR2
著者Park, H, Rader, C.
登録日2019-05-01
公開日2020-04-01
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.083 Å)
主引用文献Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSH
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BU of 6osh by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
分子名称: Antibody Light chain variable region, Antibody heavy chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
著者Park, H, Rader, C.
登録日2019-05-01
公開日2020-04-01
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.117 Å)
主引用文献Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6U85
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BU of 6u85 by Molmil
Site-specific lysine arylation as an alternative bioconjugation strategy for chemically programmed antibodies and antibody-drug conjugates
分子名称: Antibody Fab heavy chain, GLYCEROL, antibody Fab Light chain
著者Park, H, Rader, C.
登録日2019-09-04
公開日2019-11-13
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Site-Specific Lysine Arylation as an Alternative Bioconjugation Strategy for Chemically Programmed Antibodies and Antibody-Drug Conjugates.
Bioconjug.Chem., 30, 2019

 

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