6ZA6
 
 | | M. tuberculosis salicylate synthase MbtI in complex with Ba2+ | | 分子名称: | BARIUM ION, CHLORIDE ION, GLYCEROL, ... | | 著者 | Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M. | | 登録日 | 2020-06-04 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.804 Å) | | 主引用文献 | Shedding X-ray Light on the Role of Magnesium in the Activity ofMycobacterium tuberculosisSalicylate Synthase (MbtI) for Drug Design.
J.Med.Chem., 63, 2020
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6ZA5
 | | M. tuberculosis salicylate synthase MbtI in complex with salicylate and Mg2+ | | 分子名称: | 2-HYDROXYBENZOIC ACID, ACETATE ION, MAGNESIUM ION, ... | | 著者 | Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M. | | 登録日 | 2020-06-04 | | 公開日 | 2020-07-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.109 Å) | | 主引用文献 | Shedding X-ray Light on the Role of Magnesium in the Activity ofMycobacterium tuberculosisSalicylate Synthase (MbtI) for Drug Design.
J.Med.Chem., 63, 2020
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6ZA4
 | | M. tuberculosis salicylate synthase MbtI in complex with 5-(3-cyanophenyl)furan-2-carboxylate | | 分子名称: | 5-(3-cyanophenyl)furan-2-carboxylic acid, CHLORIDE ION, Salicylate synthase | | 著者 | Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M. | | 登録日 | 2020-06-04 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | | 主引用文献 | Shedding X-ray Light on the Role of Magnesium in the Activity ofMycobacterium tuberculosisSalicylate Synthase (MbtI) for Drug Design.
J.Med.Chem., 63, 2020
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8QN5
 | | M. tuberculosis salicylate synthase MbtI in complex with methyl-AMT (new crystal form) | | 分子名称: | 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, AMMONIUM ION, CITRATE ANION, ... | | 著者 | Mori, M, Villa, S, Meneghetti, M, Bellinzoni, M. | | 登録日 | 2023-09-25 | | 公開日 | 2023-11-15 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.544 Å) | | 主引用文献 | Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery.
Pharmaceuticals, 16, 2023
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8QC4
 | | M. tuberculosis salicylate synthase MbtI in complex with 5-(3-carboxyphenyl)furan-2-carboxylic acid | | 分子名称: | 5-(3-carboxyphenyl)furan-2-carboxylic acid, GLYCEROL, SULFATE ION, ... | | 著者 | Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M. | | 登録日 | 2023-08-25 | | 公開日 | 2023-11-15 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.578 Å) | | 主引用文献 | Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery.
Pharmaceuticals, 16, 2023
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2K4W
 | | The Solution Structure of the Monomeric Copper, Zinc Superoxide Dismutase from Salmonella enterica | | 分子名称: | COPPER (I) ION, Superoxide dismutase [Cu-Zn], ZINC ION | | 著者 | Mori, M, Jimenez, B, Piccioli, M, Battistoni, A, Sette, M, Structural Proteomics in Europe (SPINE) | | 登録日 | 2008-06-20 | | 公開日 | 2008-11-18 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Solution Structure of the Monomeric Copper, Zinc Superoxide Dismutase from Salmonella enterica: Structural Insights To Understand the Evolution toward the Dimeric Structure.
Biochemistry, 47, 2008
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4YCN
 | | Crystal structure of the calcium pump with bound marine macrolide BLLB | | 分子名称: | (4S,5E,8S,9E,11S,13E,15E,18R)-4-hydroxy-8-methoxy-9,11-dimethyl-18-[(1Z,4E)-2-methylhexa-1,4-dien-1-yl]oxacyclooctadeca-5,9,13,15-tetraen-2-one, PHOSPHATIDYLETHANOLAMINE, SODIUM ION, ... | | 著者 | Morita, M, Ogawa, H, Ohno, O, Yamori, T, Suenaga, K, Toyoshima, C. | | 登録日 | 2015-02-20 | | 公開日 | 2016-01-13 | | 最終更新日 | 2020-02-05 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca(2+) pumps with a unique mode of binding
Febs Lett., 589, 2015
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4YCM
 | | Crystal structure of the calcium pump with bound marine macrolide BLS | | 分子名称: | (4S,5E,8S,9E,11S,13E,15E,18R)-8-methoxy-9,11-dimethyl-18-[(1Z,4E)-2-methylhexa-1,4-dien-1-yl]-2-oxooxacyclooctadeca-5,9,13,15-tetraen-4-yl 3-O-methyl-beta-D-glucopyranoside, PHOSPHATIDYLETHANOLAMINE, SODIUM ION, ... | | 著者 | Morita, M, Ogawa, H, Ohno, O, Yamori, T, Suenaga, K, Toyoshima, C. | | 登録日 | 2015-02-20 | | 公開日 | 2016-01-13 | | 最終更新日 | 2020-02-05 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca(2+) pumps with a unique mode of binding
Febs Lett., 589, 2015
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3J6H
 | | Nucleotide-free Kinesin motor domain complexed with GMPCPP-microtubule | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin heavy chain isoform 5C, MAGNESIUM ION, ... | | 著者 | Morikawa, M, Yajima, H, Nitta, R, Inoue, S, Ogura, T, Sato, C, Hirokawa, N. | | 登録日 | 2014-02-21 | | 公開日 | 2015-04-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (8.1 Å) | | 主引用文献 | X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding
Embo J., 2015
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7CTR
 | | Closed form of PET-degrading cutinase Cut190 with thermostability-improving mutations of S226P/R228S/Q138A/D250C-E296C/Q123H/N202H | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, Alpha/beta hydrolase family protein | | 著者 | Emori, M, Numoto, N, Senga, A, Bekker, G.J, Kamiya, N, Ito, N, Kawai, F, Oda, M. | | 登録日 | 2020-08-20 | | 公開日 | 2021-02-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structural basis of mutants of PET-degrading enzyme from Saccharomonospora viridis AHK190 with high activity and thermal stability.
Proteins, 89, 2021
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7CTS
 | | Open form of PET-degrading cutinase Cut190 with thermostability-improving mutations of S226P/R228S/Q138A/D250C-E296C/Q123H/N202H and S176A inactivation | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, Alpha/beta hydrolase family protein, BICINE, ... | | 著者 | Emori, M, Numoto, N, Senga, A, Bekker, G.J, Kamiya, N, Ito, N, Kawai, F, Oda, M. | | 登録日 | 2020-08-20 | | 公開日 | 2021-02-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Structural basis of mutants of PET-degrading enzyme from Saccharomonospora viridis AHK190 with high activity and thermal stability.
Proteins, 89, 2021
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5AVB
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5AV9
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5AV8
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5AV5
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-11 | | 公開日 | 2015-12-23 | | 最終更新日 | 2020-02-19 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5AV6
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5AVC
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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8QBT
 | | E. coli ApdP-stalled ribosomal complex | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S11, ... | | 著者 | Morici, M, Wilson, D.N. | | 登録日 | 2023-08-25 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity.
Nat Commun, 15, 2024
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8QCQ
 | | B. subtilis ApdA-stalled ribosomal complex | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Morici, M, Wilson, D.N. | | 登録日 | 2023-08-28 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity.
Nat Commun, 15, 2024
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8QIJ
 | | Crystallographic Structure of a Salicylate Synthase from M. abscessus (Mab-SaS) | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Cassetta, A, Covaceuszach, S, Tomaiuolo, M, Meneghetti, F, Villa, S, Mori, M, Chiarelli, L.R, Mangiatordi, G.F. | | 登録日 | 2023-09-12 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.073 Å) | | 主引用文献 | Structural basis for specific inhibition of salicylate synthase from Mycobacterium abscessus.
Eur.J.Med.Chem., 265, 2024
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4GUY
 | | Human MMP12 catalytic domain in complex with*N*-Hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide | | 分子名称: | CALCIUM ION, Macrophage metalloelastase, N-hydroxy-N~2~-{[2-(4-methoxyphenyl)ethyl]sulfonyl}glycinamide, ... | | 著者 | Calderone, V, Fragai, M, Luchinat, C, Massaro, A, Mordini, A, Mori, M. | | 登録日 | 2012-08-30 | | 公開日 | 2012-09-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Contribution of free energy of solvation to ligand affinity in new potent MMPs inhibitors.
To be Published
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7EAU
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5GSY
 | | Kinesin-8 motor, KIF19A, in the nucleotide-free state complexed with GDP-taxol microtubule | | 分子名称: | Kinesin-like protein KIF19 | | 著者 | Morikawa, M, Nitta, R, Yajima, H, Shigematsu, H, Kikkawa, M, Hirokawa, N. | | 登録日 | 2016-08-17 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (7 Å) | | 主引用文献 | Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A
Elife, 5, 2016
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1H2G
 | | Altered substrate specificity mutant of penicillin acylase | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, PENICILLIN G ACYLASE ALPHA SUBUNIT, ... | | 著者 | McVey, C.E, Morillas, M, Brannigan, J.A, Ladurner, A.G, Forney, L.J, Virden, R. | | 登録日 | 2002-08-08 | | 公開日 | 2003-07-17 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Mutations of Penicillin Acylase Residue B71 Extend Substrate Specificity by Decreasing Steric Constraints for Substrate Binding
Biochem.J., 371, 2003
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5XXX
 | | GMPCPP-microtubule complexed with nucleotide-free KIF5C | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | 著者 | Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N. | | 登録日 | 2017-07-05 | | 公開日 | 2018-10-10 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (6.43 Å) | | 主引用文献 | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport
J. Cell Biol., 217, 2018
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