1N45
| X-RAY CRYSTAL STRUCTURE OF HUMAN HEME OXYGENASE-1 (HO-1) IN COMPLEX WITH ITS SUBSTRATE HEME | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, heme oxygenase 1 | 著者 | Schuller, D.J, Wilks, A, Ortiz de Montellano, P.R, Poulos, T.L. | 登録日 | 2002-10-30 | 公開日 | 2002-11-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1. J. Biol. Chem., 278, 2003
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1N3U
| Crystal structure of human heme oxygenase 1 (HO-1) in complex with its substrate heme, crystal form B | 分子名称: | CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, heme oxygenase 1 | 著者 | Lad, L, Schuller, D.J, Friedman, J.P, Li, H, Ortiz de Montellano, P.R, Poulos, T.L. | 登録日 | 2002-10-29 | 公開日 | 2002-11-06 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1 J.Biol.Chem., 278, 2003
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1ME5
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1F4T
| THERMOPHILIC P450: CYP119 FROM SULFOLOBUS SOLFACTARICUS WITH 4-PHENYLIMIDAZOLE BOUND | 分子名称: | 4-PHENYL-1H-IMIDAZOLE, CYTOCHROME P450 119, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Yano, J.K, Koo, L.S, Schuller, D.J, Li, H, Ortiz de Montellano, P.R, Poulos, T.L. | 登録日 | 2000-06-09 | 公開日 | 2000-10-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus. J.Biol.Chem., 275, 2000
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1LW1
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1GU9
| Crystal Structure of Mycobacterium tuberculosis Alkylperoxidase AhpD | 分子名称: | ALKYLHYDROPEROXIDASE D | 著者 | Nunn, C.M, Djordjevic, S, Hillas, P.J, Nishida, C, Ortiz de Montellano, P.R. | 登録日 | 2002-01-24 | 公開日 | 2002-02-14 | 最終更新日 | 2018-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Crystal Structure of Mycobacterium Tuberculosis Alkylhydroperoxidase Ahpd, a Potential Target for Antitubercular Drug Design J.Biol.Chem., 277, 2002
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4APY
| Ethylene glycol-bound form of P450 CYP125A3 from Mycobacterium smegmatis | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, P450 HEME-THIOLATE PROTEIN, ... | 著者 | Frank, D.J, Garcia Fernandez, E, Kells, P.M, Garcia Lopez, J.L, Podust, L.M, Ortiz de Montellano, P.R. | 登録日 | 2012-04-09 | 公開日 | 2013-02-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Highly Conserved Mycobacterial Cholesterol Catabolic Pathway. Environ.Microbiol., 15, 2013
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3ZBY
| Ligand-free structure of CYP142 from Mycobacterium smegmatis | 分子名称: | 1,2-ETHANEDIOL, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), P450 HEME-THIOLATE PROTEIN, ... | 著者 | Garcia-Fernandez, E, Frank, D.J, Galan, B, Kells, P.M, Podust, L.M, Garcia, J.L, Ortiz de Montellano, P.R. | 登録日 | 2012-11-13 | 公開日 | 2013-02-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | A Highly Conserved Mycobacterial Cholesterol Catabolic Pathway. Environ.Microbiol., 15, 2013
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2NSD
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2XN8
| X-RAY STRUCTURE OF THE SUBSTRATE-FREE MYCOBACTERIUM TUBERCULOSIS CYTOCHROME P450 CYP125 | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 125, SULFATE ION | 著者 | Ouellet, H, Kells, P.M, Ortiz de Montellano, P.R, Podust, L.M. | 登録日 | 2010-07-30 | 公開日 | 2010-11-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Reverse Type I Inhibitor of Mycobacteriumtuberculosis Cyp125A1. Bioorg.Med.Chem.Lett., 21, 2011
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2YOO
| Cholest-4-en-3-one bound structure of CYP142 from Mycobacterium smegmatis | 分子名称: | (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, MAGNESIUM ION, P450 HEME-THIOLATE PROTEIN, ... | 著者 | Garcia-Fernandez, E, Frank, D.J, Galan, B, Kells, P.M, Podust, L.M, Garcia, J.L, Ortiz de Montellano, P.R. | 登録日 | 2012-10-25 | 公開日 | 2013-02-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | A Highly Conserved Mycobacterial Cholesterol Catabolic Pathway. Environ.Microbiol., 15, 2013
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2XC3
| X-ray structure of Mycobacterium tuberculosis cyp125 bound to the reverse type I inhibitor | 分子名称: | NALPHA-[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]-N-PYRIDIN-4-YL-D-TRYPTOPHANAMIDE, PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 125 | 著者 | Ouellet, H, Kells, P.M, Ortiz de Montellano, P.R, Podust, L.M. | 登録日 | 2010-04-16 | 公開日 | 2010-11-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Reverse Type I Inhibitor of Mycobacteriumtuberculosis Cyp125A1. Bioorg.Med.Chem.Lett., 21, 2011
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2H7R
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2H7S
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2H7Q
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2WGY
| Crystal structure of the G243A mutant of CYP130 from M. tuberculosis | 分子名称: | CYTOCHROME P450 130, ISOPROPYL ALCOHOL, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Podust, L.M, Ouellet, H, von Kries, J.P, Ortiz de Montellano, P.R. | 登録日 | 2009-04-28 | 公開日 | 2009-05-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines. J. Biol. Chem., 284, 2009
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2WH8
| Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines | 分子名称: | 5-AMINO-2-{4-[(4-AMINOPHENYL)SULFANYL]PHENYL}-1H-ISOINDOLE-1,3(2H)-DIONE, PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 130 | 著者 | Podust, L.M, Ouellet, H, von Kries, J.P, Ortiz de Montellano, P.R. | 登録日 | 2009-05-01 | 公開日 | 2009-07-14 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines. J. Biol. Chem., 284, 2009
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2WHF
| Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines | 分子名称: | 1-(3-METHYLPHENYL)-1H-BENZIMIDAZOL-5-AMINE, PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 130 | 著者 | Podust, L.M, Ouellet, H, von Kries, J.P, Ortiz de Montellano, P.R. | 登録日 | 2009-05-04 | 公開日 | 2009-07-14 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines. J. Biol. Chem., 284, 2009
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4TRJ
| Crystal structure of Mycobacterium tuberculosis enoyl reductase (INHA) complexed with N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide, refined with new ligand restraints | 分子名称: | (3S)-N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | He, X, Alian, A, Stroud, R.M, Ortiz de Montellano, P.R. | 登録日 | 2014-06-17 | 公開日 | 2014-08-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis J. Med. Chem., 2006
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4TZK
| Crystal structure of Mycobacterium tuberculosis enoyl reductase (INHA) complexed WITH 1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE | 分子名称: | (3S)-1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | He, X, Alian, A, Stroud, R.M, Ortiz de Montellano, P.R. | 登録日 | 2014-07-10 | 公開日 | 2014-08-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis J. Med. Chem., 2006
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4U0J
| Crystal structure of Mycobacterium tuberculosis enoyl reductase (INHA) complexed with 1-CYCLOHEXYL-5-OXO-N-PHENYLPYRROLIDINE-3-CARBOXAMIDE, refined with new ligand restraints | 分子名称: | (3S)-1-CYCLOHEXYL-5-OXO-N-PHENYLPYRROLIDINE-3-CARBOXAMIDE, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | He, X, Alian, A, Stroud, R.M, Ortiz de Montellano, P.R. | 登録日 | 2014-07-11 | 公開日 | 2014-07-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis J. Med. Chem., 2006
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4U0K
| Crystal structure of Mycobacterium tuberculosis enoyl reductase complexed with N-(5-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide | 分子名称: | (3S)-N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | He, X, Alian, A, Stroud, R.M, Ortiz de Montellano, P.R. | 登録日 | 2014-07-11 | 公開日 | 2014-07-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis J. Med. Chem., 2006
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4TZT
| CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL- 5-OXOPYRROLIDINE-3-CARBOXAMIDE | 分子名称: | (3S)-N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | He, X, Alian, A, Stroud, R.M, Ortiz de Montellano, P.R. | 登録日 | 2014-07-10 | 公開日 | 2014-08-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis J. Med. Chem., 2006
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1XJZ
| Crystal Structures of the G139A, G139A-NO and G143H Mutants of Human Heme Oxygenase-1 | 分子名称: | Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Lad, L, Ortiz de Montellano, P.R, Poulos, T.L. | 登録日 | 2004-09-26 | 公開日 | 2005-10-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Crystal Structures of the G139A, G139A-NO and G143H Mutants of Human Heme Oxygenase-1. A finely tuned hydrogen-bonding network controls oxygenase versus peroxidase activity. J.Biol.Inorg.Chem., 10, 2005
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1XK1
| Crystal Structures of the G139A, G139A-NO and G143H Mutants of Human Heme Oxygenase-1 | 分子名称: | Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Lad, L, Ortiz de Montellano, P.R, Poulos, T.L. | 登録日 | 2004-09-26 | 公開日 | 2005-12-13 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Crystal structures of the G139A, G139A-NO and G143H mutants of human heme oxygenase-1. A finely tuned hydrogen-bonding network controls oxygenase versus peroxidase activity. J.Biol.Inorg.Chem., 10, 2005
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