6I4R
 
 | | Crystal structure of the disease-causing R460G mutant of the human dihydrolipoamide dehydrogenase at 1.44 Angstrom resolution | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dihydrolipoyl dehydrogenase, mitochondrial, ... | | 著者 | Szabo, E, Wilk, P, Bui, D, Torocsik, B, Weiss, M.S, Adam-Vizi, V, Ambrus, A. | | 登録日 | 2018-11-10 | | 公開日 | 2019-11-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.439 Å) | | 主引用文献 | Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 28, 2019
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6I4S
 | | Crystal structure of the disease-causing R447G mutant of the human dihydrolipoamide dehydrogenase | | 分子名称: | Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Szabo, E, Wilk, P, Hubert, A, Torocsik, B, Weiss, M.S, Adam-Vizi, V, Ambrus, A. | | 登録日 | 2018-11-10 | | 公開日 | 2019-11-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 28, 2019
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6H0X
 | | Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA040 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysine-specific demethylase 4D, ... | | 著者 | Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. | | 登録日 | 2018-07-10 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA040
To be published
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6H2P
 | | Crystal Structure of Arg184Gln mutant of Human Prolidase with Mn ions and Cacodylate ligand | | 分子名称: | CACODYLATE ION, GLYCEROL, MANGANESE (II) ION, ... | | 著者 | Wilk, P, Piwowarczyk, R, Weiss, M.S. | | 登録日 | 2018-07-14 | | 公開日 | 2018-08-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.479 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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6H11
 | | Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA028 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysine-specific demethylase 4D, ... | | 著者 | Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. | | 登録日 | 2018-07-10 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.516 Å) | | 主引用文献 | Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA028
To be published
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6H0W
 | | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS035 | | 分子名称: | (2~{R})-3-phenyl-2-(2~{H}-1,2,3,4-tetrazol-5-yl)propanehydrazide, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. | | 登録日 | 2018-07-10 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | | 主引用文献 | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS035
To be published
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6I4T
 | | Crystal structure of the disease-causing I445M mutant of the human dihydrolipoamide dehydrogenase | | 分子名称: | Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Szabo, E, Wilk, P, Zambo, Z, Torocsik, B, Weiss, M.S, Adam-Vizi, V, Ambrus, A. | | 登録日 | 2018-11-10 | | 公開日 | 2019-11-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.823 Å) | | 主引用文献 | Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 28, 2019
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6H0Y
 | | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS022 | | 分子名称: | (2~{R})-3-(4-methoxyphenyl)-2-(2~{H}-1,2,3,4-tetrazol-5-yl)propanehydrazide, 1,2-ETHANEDIOL, Lysine-specific demethylase 4D, ... | | 著者 | Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. | | 登録日 | 2018-07-10 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.212 Å) | | 主引用文献 | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS022
To be published
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6GKO
 | | Mouse thymidylate synthase cocrystallized with dUMP and soaked in phenolphthalein | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one, DIMETHYL SULFOXIDE, ... | | 著者 | Maj, P, Wilk, P, Jarmula, A, Weiss, M.S, Rode, W. | | 登録日 | 2018-05-21 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.839 Å) | | 主引用文献 | Thymidylate synthase fragment screening
To Be Published
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6H10
 | | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR073 | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... | | 著者 | Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. | | 登録日 | 2018-07-10 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.104 Å) | | 主引用文献 | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR073
To be published
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5M4J
 | | Crystal Structure of Wild-Type Human Prolidase with GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, PROLINE, ... | | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | | 登録日 | 2016-10-18 | | 公開日 | 2017-07-12 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase.
FEBS J., 284, 2017
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5M4Q
 | | Crystal Structure of Wild-Type Human Prolidase with Mn ions and Pro ligand | | 分子名称: | GLYCEROL, HYDROXIDE ION, MANGANESE (II) ION, ... | | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | | 登録日 | 2016-10-18 | | 公開日 | 2017-07-12 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase.
FEBS J., 284, 2017
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5MBZ
 | | Crystal Structure of Ser202Phe mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | CHLORIDE ION, GLYCEROL, GLYCINE, ... | | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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5MC5
 | | Crystal Structure of delGlu452 mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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5MC3
 | | Crystal Structure of Glu412Lys mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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5MC0
 | | Crystal Structure of delTyr231 mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | CHLORIDE ION, GLYCEROL, GLYCINE, ... | | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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5MC4
 | | Crystal Structure of Gly448Arg mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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5MC2
 | | Crystal Structure of Gly278Asp mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, MANGANESE (II) ION, ... | | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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5M4G
 | | Crystal Structure of Wild-Type Human Prolidase with Mn ions | | 分子名称: | GLYCEROL, HYDROXIDE ION, MANGANESE (II) ION, ... | | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | | 登録日 | 2016-10-18 | | 公開日 | 2017-07-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase.
FEBS J., 284, 2017
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5MC1
 | | Crystal Structure of Asp276Asn mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, MANGANESE (II) ION, ... | | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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5NHG
 | | Crystal structure of the human dihydrolipoamide dehydrogenase | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dihydrolipoyl dehydrogenase, ... | | 著者 | Szabo, E, Mizsei, R, Wilk, P, Zambo, Z, Torocsik, B, Weiss, M.S, Adam-Vizi, V, Ambrus, A. | | 登録日 | 2017-03-21 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase.
Free Radic. Biol. Med., 124, 2018
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5M4L
 | | Crystal Structure of Wild-Type Human Prolidase with Mg ions and LeuPro ligand | | 分子名称: | GLYCEROL, HYDROXIDE ION, LEUCINE, ... | | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | | 登録日 | 2016-10-18 | | 公開日 | 2017-07-12 | | 最終更新日 | 2020-04-22 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase.
FEBS J., 284, 2017
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5MBY
 | | Crystal Structure of Arg184Gln mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | | 著者 | Wilk, P, Piwowarczyk, R, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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6Y08
 | | Mouse thymidylate synthase cocrystallized with dUMP and soaked in sulfamethoxazole | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Sulfamethoxazole, Thymidylate synthase | | 著者 | Maj, P, Jarmula, A, Wilk, P, Weiss, M.S, Rode, W. | | 登録日 | 2020-02-06 | | 公開日 | 2021-02-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.297 Å) | | 主引用文献 | Mouse thymidylate synthase cocrystallized with dUMP and soaked in sulfamethoxazole
To Be Published
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1LK9
 | | The Three-dimensional Structure of Alliinase from Garlic | | 分子名称: | 2-AMINO-ACRYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Kuettner, E.B, Hilgenfeld, R, Weiss, M.S. | | 登録日 | 2002-04-24 | | 公開日 | 2002-12-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | The active principle of garlic at atomic resolution
J.Biol.Chem., 277, 2002
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