5NHG

Crystal structure of the human dihydrolipoamide dehydrogenase

Summary for 5NHG

Entry DOI	10.2210/pdb5nhg/pdb
Descriptor	Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
Functional Keywords	dihydrolipoamide dehydrogenase, e3 subunit, oxidoreductase, pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase complex
Biological source	Homo sapiens (Human)
Total number of polymer chains	8
Total formula weight	427396.48
Authors	Szabo, E.,Mizsei, R.,Wilk, P.,Zambo, Z.,Torocsik, B.,Weiss, M.S.,Adam-Vizi, V.,Ambrus, A. (deposition date: 2017-03-21, release date: 2018-05-16, Last modification date: 2024-01-17)
Primary citation	Szabo, E.,Mizsei, R.,Wilk, P.,Zambo, Z.,Torocsik, B.,Weiss, M.S.,Adam-Vizi, V.,Ambrus, A. Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase. Free Radic. Biol. Med., 124:214-220, 2018 Cited by PubMed: 29908278 DOI: 10.1016/j.freeradbiomed.2018.06.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation