4G6O
 
 | | Crystal Structure of the ERK2 | | 分子名称: | 1,2-ETHANEDIOL, 4-{4-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}-N-(2,3-dihydro-1-benzofuran-5-ylmethyl)-1H-pyrrole-2-carboxamide, Mitogen-activated protein kinase 1, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | | 登録日 | 2012-07-19 | | 公開日 | 2012-09-19 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal Structure of the ERK2 complexed with E28
to be published
|
|
4FSU
 | | Crystal Structure of the CHK1 | | 分子名称: | 4-[6-(1H-imidazol-1-ylmethyl)-7-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl]benzonitrile, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Chang, P, Russell, A.J. | | 登録日 | 2012-06-27 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of the CHK1
To be Published
|
|
4FT5
 | | Crystal Structure of the CHK1 | | 分子名称: | 1-{5-chloro-2-[(3R)-pyrrolidin-3-yloxy]phenyl}-3-(5-cyanopyrazin-2-yl)urea, GLYCEROL, SULFATE ION, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Chang, P, Russell, A.J. | | 登録日 | 2012-06-27 | | 公開日 | 2012-08-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structure of the CHK1
To be Published
|
|
4FTO
 | | Crystal Structure of the CHK1 | | 分子名称: | 4-{7-methoxy-6-[3-(morpholin-4-yl)propoxy]-1,4-dihydroindeno[1,2-c]pyrazol-3-yl}benzonitrile, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Chang, P, Russell, A.J. | | 登録日 | 2012-06-27 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of the CHK1
To be Published
|
|
4FUG
 | | Crystal Structure of the Urokinase | | 分子名称: | ACETATE ION, GLYCEROL, SULFATE ION, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. | | 登録日 | 2012-06-28 | | 公開日 | 2012-08-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structure of the Urokinase
to be published
|
|
4FUY
 | |
4FV9
 | | Crystal Structure of the ERK2 complexed with E71 | | 分子名称: | 1,2-ETHANEDIOL, 3-[4-(2,3-difluorophenyl)-1,2-oxazol-5-yl]-5-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine, Mitogen-activated protein kinase 1, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | | 登録日 | 2012-06-29 | | 公開日 | 2012-08-29 | | 最終更新日 | 2014-09-24 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Crystal Structure of the ERK2 complexed with E71
TO BE PUBLISHED
|
|
4G6N
 | | Crystal Structure of the ERK2 | | 分子名称: | 3-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-indazole, Mitogen-activated protein kinase 1, SULFATE ION | | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | | 登録日 | 2012-07-19 | | 公開日 | 2012-09-19 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of the ERK2 complexed with EK0
to be published
|
|
4FU7
 | | Crystal Structure of the Urokinase | | 分子名称: | 2-[(7-carbamimidoyl-2-methoxynaphthalen-1-yl)oxy]acetamide, ACETATE ION, SULFATE ION, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. | | 登録日 | 2012-06-28 | | 公開日 | 2012-08-22 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of the Urokinase
to be published
|
|
4FUE
 | | Crystal Structure of the Urokinase | | 分子名称: | 6-(1,2,3,4-tetrahydroisoquinolin-6-ylethynyl)naphthalene-2-carboximidamide, ACETATE ION, GLYCEROL, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. | | 登録日 | 2012-06-28 | | 公開日 | 2012-08-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of the Urokinase
to be published
|
|
4FV1
 | |
4FW3
 | |
4FSY
 | | Crystal Structure of the CHK1 | | 分子名称: | 2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-3-yl)benzamide, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Chang, P, Russell, A.J. | | 登録日 | 2012-06-27 | | 公開日 | 2012-08-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structure of the CHK1
To be Published
|
|
4FUH
 | | Crystal Structure of the Urokinase | | 分子名称: | 6-[(phenylcarbamoyl)amino]naphthalene-2-carboximidamide, ACETATE ION, GLYCEROL, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. | | 登録日 | 2012-06-28 | | 公開日 | 2012-08-22 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal Structure of the Urokinase
to be published
|
|
4FV4
 | | Crystal Structure of the ERK2 complexed with EK7 | | 分子名称: | 9-(dimethylamino)-2-[(3-hydroxyphenyl)amino]-5,6-dihydrothieno[3,4-h]quinazoline-7-carbonitrile, GLYCEROL, Mitogen-activated protein kinase 1, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | | 登録日 | 2012-06-29 | | 公開日 | 2012-08-29 | | 最終更新日 | 2014-09-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of the ERK2 complexed with EK7
TO BE PUBLISHED
|
|
4FW6
 | |
4FKP
 | |
4FKO
 | |
4FKJ
 | |
4FKW
 | |
6E1A
 | | Menin bound to M-89 | | 分子名称: | (1S,2R)-2-[(4S)-2-methyl-4-{1-[(1-{4-[(pyridin-4-yl)sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}-1,2,3,4-tetrahydroisoquinolin-4-yl]cyclopentyl methylcarbamate, Menin, praseodymium triacetate | | 著者 | Stuckey, J.A. | | 登録日 | 2018-07-09 | | 公開日 | 2019-07-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction.
J.Med.Chem., 62, 2019
|
|
6WNH
 | | Menin bound to inhibitor M-808 | | 分子名称: | Menin, methyl [(1S,2R)-2-{(1S)-2-(azetidin-1-yl)-1-(3-fluorophenyl)-1-[1-({1-[4-({1-[4-(piperidin-1-yl)butanoyl]azetidin-3-yl}sulfonyl)phenyl]azetidin-3-yl}methyl)piperidin-4-yl]ethyl}cyclopentyl]carbamate, praseodymium triacetate | | 著者 | Stuckey, J.A. | | 登録日 | 2020-04-22 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with StrongIn VivoAntitumor Activity.
J.Med.Chem., 63, 2020
|
|
6B41
 | | Menin bound to M-525 | | 分子名称: | Menin, methyl {(1S,2R)-2-[(S)-cyano[1-({1-[4-({1-[4-(dimethylamino)butanoyl]azetidin-3-yl}sulfonyl)phenyl]azetidin-3-yl}methyl)piperidin-4-yl](3-fluorophenyl)methyl]cyclopentyl}carbamate, praseodymium triacetate | | 著者 | Stuckey, J.A. | | 登録日 | 2017-09-25 | | 公開日 | 2018-01-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.
Angew. Chem. Int. Ed. Engl., 57, 2018
|
|
8SX4
 | | Crystal Structure of eIF4e in complex with Compound 7n | | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E, [(~{Z})-4-[2-azanyl-7-[(5-chloranyl-1~{H}-indol-2-yl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]but-2-enyl]phosphonic acid | | 著者 | Meagher, J.L, Stuckey, J.A. | | 登録日 | 2023-05-19 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.986 Å) | | 主引用文献 | Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer.
J.Med.Chem., 66, 2023
|
|
1YTN
 | | HYDROLASE | | 分子名称: | NITRATE ION, YERSINIA PROTEIN TYROSINE PHOSPHATASE | | 著者 | Yuvaniyama, C, Fauman, E.B, Saper, M.A. | | 登録日 | 1996-05-01 | | 公開日 | 1996-11-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications.
J.Biol.Chem., 271, 1996
|
|
