4FW3
 
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4FSY
 | | Crystal Structure of the CHK1 | | 分子名称: | 2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-3-yl)benzamide, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Chang, P, Russell, A.J. | | 登録日 | 2012-06-27 | | 公開日 | 2012-08-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structure of the CHK1
To be Published
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4FUH
 | | Crystal Structure of the Urokinase | | 分子名称: | 6-[(phenylcarbamoyl)amino]naphthalene-2-carboximidamide, ACETATE ION, GLYCEROL, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. | | 登録日 | 2012-06-28 | | 公開日 | 2012-08-22 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal Structure of the Urokinase
to be published
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4FV4
 | | Crystal Structure of the ERK2 complexed with EK7 | | 分子名称: | 9-(dimethylamino)-2-[(3-hydroxyphenyl)amino]-5,6-dihydrothieno[3,4-h]quinazoline-7-carbonitrile, GLYCEROL, Mitogen-activated protein kinase 1, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | | 登録日 | 2012-06-29 | | 公開日 | 2012-08-29 | | 最終更新日 | 2014-09-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of the ERK2 complexed with EK7
TO BE PUBLISHED
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4FW6
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4FKO
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4FKJ
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4FKW
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4FKR
 | | Crystal structure of the cdk2 in complex with oxindole inhibitor | | 分子名称: | (8Z)-8-{[(2,2-dioxido-1,3-dihydro-2-benzothiophen-5-yl)amino]methylidene}-6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one, Cyclin-dependent kinase 2, GLYCEROL | | 著者 | Kang, Y.N, Stuckey, J.A. | | 登録日 | 2012-06-13 | | 公開日 | 2013-05-08 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of the cdk2 in complex with oxindole inhibitor
To be Published
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4FKL
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4J09
 | | Crystal Structure of LpxA bound to RJPXD33 | | 分子名称: | 1,2-ETHANEDIOL, Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, DIMETHYL SULFOXIDE, ... | | 著者 | Jenkins, R.J, Meagher, J.L, Stuckey, J.A, Dotson, G.D. | | 登録日 | 2013-01-30 | | 公開日 | 2014-04-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Basis for the Recognition of Peptide RJPXD33 by Acyltransferases in Lipid A Biosynthesis.
J.Biol.Chem., 289, 2014
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4FUB
 | | Crystal Structure of the Urokinase | | 分子名称: | 6-[(2S,3S)-3-phenyloxiran-2-yl]naphthalene-2-carboximidamide, ACETATE ION, GLYCEROL, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. | | 登録日 | 2012-06-28 | | 公開日 | 2012-08-22 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structure of the Urokinase
to be published
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4FV2
 | | Crystal Structure of the ERK2 complexed with EK5 | | 分子名称: | 1,2-ETHANEDIOL, 4-[4-(3-chlorophenyl)-1H-pyrazol-5-yl]-N-(2,3-dihydro-1-benzofuran-5-ylmethyl)-1H-pyrrole-2-carboxamide, GLYCEROL, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | | 登録日 | 2012-06-29 | | 公開日 | 2012-08-29 | | 最終更新日 | 2014-09-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of the ERK2 complexed with EK5
TO BE PUBLISHED
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4FSN
 | | Crystal Structure of the CHK1 | | 分子名称: | 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID, ISOPROPYL ALCOHOL, SULFATE ION, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Chang, P, Russell, A.J. | | 登録日 | 2012-06-27 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of the CHK1
To be Published
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4G4M
 | | Crystal structure of the de novo designed fluorinated peptide alpha4F3(6-13) | | 分子名称: | 1,2-ETHANEDIOL, TETRAETHYLENE GLYCOL, alpha4F3(6-13) | | 著者 | Buer, B.C, Meagher, J.L, Stuckey, J.A, Marsh, E.N.G. | | 登録日 | 2012-07-16 | | 公開日 | 2012-10-31 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Comparison of the structures and stabilities of coiled-coil proteins containing hexafluoroleucine and t-butylalanine provides insight into the stabilizing effects of highly fluorinated amino acid side-chains.
Protein Sci., 21, 2012
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4G3B
 | | Crystal structure of the de novo designed fluorinated peptide alpha4F3d | | 分子名称: | ACETYL GROUP, alpha4F3d | | 著者 | Buer, B.C, Meagher, J.L, Stuckey, J.A, Marsh, E.N.G. | | 登録日 | 2012-07-13 | | 公開日 | 2012-10-31 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | | 主引用文献 | Comparison of the structures and stabilities of coiled-coil proteins containing hexafluoroleucine and t-butylalanine provides insight into the stabilizing effects of highly fluorinated amino acid side-chains.
Protein Sci., 21, 2012
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4FT3
 | | Crystal Structure of the CHK1 | | 分子名称: | 1-(5-chloro-2,4-dimethoxyphenyl)-3-pyrazin-2-ylurea, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Chang, P, Russell, A.J. | | 登録日 | 2012-06-27 | | 公開日 | 2012-08-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of the CHK1
To be Published
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4FV5
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4FSM
 | | Crystal Structure of the CHK1 | | 分子名称: | 4-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenol, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Chang, P, Russell, A.J. | | 登録日 | 2012-06-27 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structure of the CHK1
To be Published
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4FT9
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6E1A
 | | Menin bound to M-89 | | 分子名称: | (1S,2R)-2-[(4S)-2-methyl-4-{1-[(1-{4-[(pyridin-4-yl)sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}-1,2,3,4-tetrahydroisoquinolin-4-yl]cyclopentyl methylcarbamate, Menin, praseodymium triacetate | | 著者 | Stuckey, J.A. | | 登録日 | 2018-07-09 | | 公開日 | 2019-07-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction.
J.Med.Chem., 62, 2019
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6WNH
 | | Menin bound to inhibitor M-808 | | 分子名称: | Menin, methyl [(1S,2R)-2-{(1S)-2-(azetidin-1-yl)-1-(3-fluorophenyl)-1-[1-({1-[4-({1-[4-(piperidin-1-yl)butanoyl]azetidin-3-yl}sulfonyl)phenyl]azetidin-3-yl}methyl)piperidin-4-yl]ethyl}cyclopentyl]carbamate, praseodymium triacetate | | 著者 | Stuckey, J.A. | | 登録日 | 2020-04-22 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with StrongIn VivoAntitumor Activity.
J.Med.Chem., 63, 2020
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6B41
 | | Menin bound to M-525 | | 分子名称: | Menin, methyl {(1S,2R)-2-[(S)-cyano[1-({1-[4-({1-[4-(dimethylamino)butanoyl]azetidin-3-yl}sulfonyl)phenyl]azetidin-3-yl}methyl)piperidin-4-yl](3-fluorophenyl)methyl]cyclopentyl}carbamate, praseodymium triacetate | | 著者 | Stuckey, J.A. | | 登録日 | 2017-09-25 | | 公開日 | 2018-01-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.
Angew. Chem. Int. Ed. Engl., 57, 2018
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8SX4
 | | Crystal Structure of eIF4e in complex with Compound 7n | | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E, [(~{Z})-4-[2-azanyl-7-[(5-chloranyl-1~{H}-indol-2-yl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]but-2-enyl]phosphonic acid | | 著者 | Meagher, J.L, Stuckey, J.A. | | 登録日 | 2023-05-19 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.986 Å) | | 主引用文献 | Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer.
J.Med.Chem., 66, 2023
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1YTW
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