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6W8A
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BU of 6w8a by Molmil
K2P2.1 (TREK-1):ML335 complex, 10 mM K+
分子名称: CADMIUM ION, DODECANE, HEXADECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.002 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W8F
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BU of 6w8f by Molmil
K2P2.1 (TREK-1):ML335 complex, 0 mM K+
分子名称: CADMIUM ION, DODECANE, HEXADECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W85
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BU of 6w85 by Molmil
K2P2.1 (TREK-1):ML335 complex, 200 mM K+
分子名称: CADMIUM ION, DECANE, HEXADECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W8C
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BU of 6w8c by Molmil
K2P2.1 (TREK-1):ML335 complex, 1 mM K+
分子名称: CADMIUM ION, DODECANE, HEXADECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W82
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BU of 6w82 by Molmil
K2P2.1 (TREK-1), 50 mM K+
分子名称: CADMIUM ION, DECANE, DODECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W86
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BU of 6w86 by Molmil
K2P2.1 (TREK-1):ML335 complex, 100 mM K+
分子名称: CADMIUM ION, DECANE, DODECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.299 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W7C
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BU of 6w7c by Molmil
K2P2.1 (TREK-1), 1 mM K+
分子名称: CADMIUM ION, DECANE, DODECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-19
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W88
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BU of 6w88 by Molmil
K2P2.1 (TREK-1):ML335 complex, 30 mM K+
分子名称: CADMIUM ION, DECANE, DODECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W83
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BU of 6w83 by Molmil
K2P2.1 (TREK-1), 100 mM K+
分子名称: CADMIUM ION, DECANE, DODECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.901 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W87
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BU of 6w87 by Molmil
K2P2.1 (TREK-1):ML335 complex, 50 mM K+
分子名称: CADMIUM ION, DECANE, DODECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W7E
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BU of 6w7e by Molmil
K2P2.1 (TREK-1), 30 mM K+
分子名称: CADMIUM ION, DODECANE, HEXADECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-19
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.29 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
8U8F
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BU of 8u8f by Molmil
GPR3 Orphan G-coupled Protein Receptor in complex with Dominant Negative Gs.
分子名称: G-protein coupled receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Russell, I.C, Belousoff, M.J, Sexton, P.
登録日2023-09-17
公開日2024-03-06
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3.
Biochemistry, 63, 2024
6WI9
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BU of 6wi9 by Molmil
Human secretin receptor Gs complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Belousoff, M.J, Khoshouei, M.
登録日2020-04-09
公開日2020-08-12
最終更新日2020-09-02
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structure and dynamics of the active Gs-coupled human secretin receptor.
Nat Commun, 11, 2020
6W7D
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BU of 6w7d by Molmil
K2P2.1 (TREK-1), 10 mM K+
分子名称: CADMIUM ION, DODECANE, HEXADECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-19
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6WZG
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BU of 6wzg by Molmil
Human secretin receptor Gs complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Piper, S.J, Belousoff, M.J, Danev, R.
登録日2020-05-13
公開日2020-08-12
最終更新日2020-09-02
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Structure and dynamics of the active Gs-coupled human secretin receptor.
Nat Commun, 11, 2020
6UUN
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BU of 6uun by Molmil
CryoEM Structure of the active Adrenomedullin 1 receptor G protein complex with adrenomedullin peptide
分子名称: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
登録日2019-10-30
公開日2020-03-25
最終更新日2020-04-29
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Acs Pharmacol Transl Sci, 3, 2020
4A6X
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BU of 4a6x by Molmil
RadA C-terminal ATPase domain from Pyrococcus furiosus bound to ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA REPAIR AND RECOMBINATION PROTEIN RADA, MAGNESIUM ION
著者Marsh, M.E, Ehebauer, M.T, Scott, D, Abell, C, Blundell, T.L, Hyvonen, M.
登録日2011-11-10
公開日2012-11-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.548 Å)
主引用文献ATP Half-Sites in Rada and Rad51 Recombinases Bind Nucleotides
FEBS Open Bio, 6, 2016
4A6P
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BU of 4a6p by Molmil
RadA C-terminal ATPase domain from Pyrococcus furiosus
分子名称: DNA REPAIR AND RECOMBINATION PROTEIN RADA, PHOSPHATE ION
著者Marsh, M.E, Ehebauer, M.T, Scott, D, Abell, C, Blundell, T.L, Hyvonen, M.
登録日2011-11-08
公開日2012-11-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.498 Å)
主引用文献ATP Half-Sites in Rada and Rad51 Recombinases Bind Nucleotides
FEBS Open Bio, 6, 2016
4B2P
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BU of 4b2p by Molmil
RadA C-terminal ATPase domain from Pyrococcus furiosus bound to GTP
分子名称: DNA REPAIR AND RECOMBINATION PROTEIN RADA, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Marsh, M.E, Ehebauer, M.T, Scott, D, Abell, C, Blundell, T.L, Hyvonen, M.
登録日2012-07-17
公開日2013-07-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献ATP Half-Sites in Rada and Rad51 Recombinases Bind Nucleotides
FEBS Open Bio, 6, 2016
8OME
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BU of 8ome by Molmil
Crystal structure of hKHK-A in complex with compound-4
分子名称: Ketohexokinase, compound
著者Ebenhoch, R, Pautsch, A.
登録日2023-03-31
公開日2023-09-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.
Acta Crystallogr D Struct Biol, 79, 2023
8OMD
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BU of 8omd by Molmil
Crystal structure of mKHK in complex with compound-4
分子名称: Ketohexokinase, compound
著者Ebenhoch, R, Pautsch, A.
登録日2023-03-31
公開日2023-09-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.
Acta Crystallogr D Struct Biol, 79, 2023
8OMF
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BU of 8omf by Molmil
Crystal structure of hKHK-C in complex with compound-4
分子名称: Ketohexokinase, SULFATE ION, compound
著者Ebenhoch, R, Pautsch, A.
登録日2023-03-31
公開日2023-09-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.
Acta Crystallogr D Struct Biol, 79, 2023
8OMG
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BU of 8omg by Molmil
Crystal structure of mKHK (apo)
分子名称: Ketohexokinase
著者Ebenhoch, E, Pautsch, P.
登録日2023-03-31
公開日2023-09-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.
Acta Crystallogr D Struct Biol, 79, 2023
8OMK
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BU of 8omk by Molmil
hKHK-C in complex with ADP & fructose 1-phosphate
分子名称: 1-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-DIPHOSPHATE, Ketohexokinase, ...
著者Ebenhoch, R, Pautsch, A.
登録日2023-03-31
公開日2024-01-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Discovery of BI-9787, a Potent Zwitterionic KHK-Inhibitor with Oral Bioavailability
To Be Published
8OMJ
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BU of 8omj by Molmil
hKHK-C in complex with compound 28
分子名称: Ketohexokinase, SULFATE ION, [3-[[6-[(3~{a}~{R},6~{a}~{S})-2,3,3~{a},4,6,6~{a}-hexahydro-1~{H}-pyrrolo[3,4-c]pyrrol-5-yl]-3-cyano-4-(trifluoromethyl)pyridin-2-yl]amino]-4-methylsulfanyl-phenyl]methoxy-methyl-phosphinic acid
著者Pautsch, A, Ebenhoch, R.
登録日2023-03-31
公開日2024-07-10
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (1.978 Å)
主引用文献Discovery of BI-9787, a Potent Zwitterionic KHK-Inhibitor with Oral Bioavailability
To Be Published

224004

件を2024-08-21に公開中

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