7BMI
 
 | | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 3-fluoropyridine-2,4-dicarboxylic acid, and factor X substrate peptide fragment (39mer-4Ser) | | 分子名称: | 3-fluoranylpyridine-2,4-dicarboxylic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... | | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | | 登録日 | 2021-01-20 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases
J Fluor Chem, 247, 2021
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7BMJ
 | | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 5-fluoropyridine-2,4-dicarboxylic acid, and factor X substrate peptide fragment (39mer-4Ser) | | 分子名称: | 5-fluoranylpyridine-2,4-dicarboxylic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... | | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | | 登録日 | 2021-01-20 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases
J Fluor Chem, 247, 2021
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1WVT
 | | Crystal structure of uncharacterized protein ST2180 from Sulfolobus tokodaii | | 分子名称: | hypothetical protein ST2180 | | 著者 | Sasaki, T, Tanaka, Y, Yasutake, Y, Tsumoto, K, Tanaka, I, Kumagai, I. | | 登録日 | 2004-12-27 | | 公開日 | 2006-01-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular properties of two proteins homologous to PduO-type ATP:cob(I)alamin adenosyltransferase from Sulfolobus tokodaii
Proteins, 68, 2007
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4IC2
 | | Crystal structure of the XIAP RING domain | | 分子名称: | E3 ubiquitin-protein ligase XIAP, NICKEL (II) ION, ZINC ION | | 著者 | Linke, K, Nakatani, Y, Day, C.L. | | 登録日 | 2012-12-09 | | 公開日 | 2012-12-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase
Biochem.J., 450, 2013
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4NWZ
 | | Structure of bacterial type II NADH dehydrogenase from Caldalkalibacillus thermarum at 2.5A resolution | | 分子名称: | FAD-dependent pyridine nucleotide-disulfide oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Nakatani, Y, Heikal, A, Lott, J.S, Sazanov, L.A, Baker, E.N, Cook, G.M. | | 登録日 | 2013-12-07 | | 公開日 | 2014-02-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation.
Mol.Microbiol., 91, 2014
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3O6A
 | | F144Y/F258Y Double Mutant of Exo-beta-1,3-glucanase from Candida albicans at 2 A | | 分子名称: | Glucan 1,3-beta-glucosidase | | 著者 | Nakatani, Y, Cutfield, S.M, Cutfield, J.F. | | 登録日 | 2010-07-28 | | 公開日 | 2010-09-15 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Carbohydrate binding sites in Candida albicans exo-beta-1,3-glucanase and the role of the Phe-Phe 'clamp' at the active site entrance
Febs J., 277, 2010
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5B13
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8II0
 | | FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(3-(3-chlorophenyl)isoxazol-5-yl)-3-hydroxypicolinoyl)glycine | | 分子名称: | 2-[[5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ... | | 著者 | Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J. | | 登録日 | 2023-02-24 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity.
Angew.Chem.Int.Ed.Engl., 63, 2024
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8IHZ
 | | FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(1-(3-(4-chlorophenyl)propyl)-1H-1,2,3-triazol-4-yl)-3-hydroxypicolinoyl)glycine | | 分子名称: | 2-[[5-[1-[3-(4-chlorophenyl)propyl]-1,2,3-triazol-4-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ... | | 著者 | Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J. | | 登録日 | 2023-02-24 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity.
Angew.Chem.Int.Ed.Engl., 63, 2024
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5B3D
 | | Structure of a flagellar type III secretion chaperone, FlgN | | 分子名称: | Flagella synthesis protein FlgN | | 著者 | Nakanishi, Y, Kinoshita, M, Namba, K, Minamino, T, Imada, K. | | 登録日 | 2016-02-15 | | 公開日 | 2016-06-01 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Rearrangements of alpha-helical structures of FlgN chaperone control the binding affinity for its cognate substrates during flagellar type III export
Mol.Microbiol., 101, 2016
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5YHF
 | | Crystal structure of SecDF in Super-membrane-facing form | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, DI(HYDROXYETHYL)ETHER, Protein translocase subunit SecDF | | 著者 | Tanaka, Y, Tsukazaki, T, Yoshikaie, K, Furukawa, A. | | 登録日 | 2017-09-28 | | 公開日 | 2018-02-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Remote Coupled Drastic beta-Barrel to beta-Sheet Transition of the Protein Translocation Motor.
Structure, 26, 2018
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2D5K
 | | Crystal structure of Dps from Staphylococcus aureus | | 分子名称: | Dps family protein, GLYCEROL | | 著者 | Tanaka, Y, Yao, M, Watanabe, N, Tanaka, I. | | 登録日 | 2005-11-02 | | 公開日 | 2006-10-17 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Nucleoid compaction by MrgA(Asp56Ala/Glu60Ala) does not contribute to staphylococcal cell survival against oxidative stress and phagocytic killing by macrophages
FEMS Microbiol. Lett., 360, 2014
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2DCM
 | | The Crystal Structure of S603A Mutated Prolyl Tripeptidyl Aminopeptidase Complexed with Substrate | | 分子名称: | GLYCYLALANYL-N-2-NAPHTHYL-L-PROLINEAMIDE, dipeptidyl aminopeptidase IV, putative | | 著者 | Nakajima, Y, Ito, K, Xu, Y, Yamada, N, Onohara, Y, Yoshimoto, T. | | 登録日 | 2006-01-09 | | 公開日 | 2006-09-19 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal Structure and Mechanism of Tripeptidyl Activity of Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis
J.Mol.Biol., 362, 2006
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2D5L
 | | Crystal Structure of Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis | | 分子名称: | SULFATE ION, dipeptidyl aminopeptidase IV, putative | | 著者 | Nakajima, Y, Ito, K, Xu, Y, Yamada, N, Onohara, Y, Yoshimoto, T. | | 登録日 | 2005-11-02 | | 公開日 | 2006-09-19 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure and Mechanism of Tripeptidyl Activity of Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis
J.Mol.Biol., 362, 2006
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2YXY
 | | Crystarl structure of Hypothetical conserved protein, GK0453 | | 分子名称: | Hypothetical conserved protein, GK0453 | | 著者 | Nakamu, Y, Bessho, Y, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-04-27 | | 公開日 | 2007-10-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426
Acta Crystallogr.,Sect.F, 69, 2013
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7Y3V
 | | Crystal structure of CdpNPT in complex with harmane | | 分子名称: | 1-methyl-9H-pyrido[3,4-b]indole, Cyclic dipeptide N-prenyltransferase, PHOSPHATE ION | | 著者 | Nakashima, Y, Morita, H. | | 登録日 | 2022-06-13 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Catalytic potential of a fungal indole prenyltransferase toward beta-carbolines, harmine and harman, and their prenylation effects on antibacterial activity.
J.Biosci.Bioeng., 134, 2022
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7XVJ
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2DQ6
 | | Crystal Structure of Aminopeptidase N from Escherichia coli | | 分子名称: | Aminopeptidase N, SULFATE ION, ZINC ION | | 著者 | Nakajima, Y, Onohara, Y, Ito, K, Yoshimoto, T. | | 登録日 | 2006-05-22 | | 公開日 | 2006-08-01 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli: Crystal structure and conformational change of the methionine 260 residue involved in substrate recognition
J.Biol.Chem., 281, 2006
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5XI8
 | | Structure and function of the TPR domain | | 分子名称: | Beta-barrel assembly-enhancing protease | | 著者 | Tanaka, Y, Tsukazaki, T. | | 登録日 | 2017-04-26 | | 公開日 | 2017-10-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The TPR domain of BepA is required for productive interaction with substrate proteins and the beta-barrel assembly machinery complex.
Mol. Microbiol., 106, 2017
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5Z3C
 | | Glycosidase E178A | | 分子名称: | GLYCEROL, Glycoside hydrolase 15-related protein | | 著者 | Tanaka, Y, Chen, M, Tagami, T, Yao, M, Kimura, A. | | 登録日 | 2018-01-05 | | 公開日 | 2019-05-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural insights reveal the second base catalyst of isomaltose glucohydrolase.
Febs J., 289, 2022
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5Z3D
 | | Glycosidase F290Y | | 分子名称: | CITRIC ACID, GLYCEROL, Glycoside hydrolase 15-related protein | | 著者 | Tanaka, Y, Chen, M, Tagami, T, Yao, M, Kimura, A. | | 登録日 | 2018-01-05 | | 公開日 | 2019-05-15 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Structural insights reveal the second base catalyst of isomaltose glucohydrolase.
Febs J., 289, 2022
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5Z3B
 | | Glycosidase Y48F | | 分子名称: | CITRIC ACID, GLYCEROL, Glycoside hydrolase 15-related protein | | 著者 | Tanaka, Y, Chen, M, Tagami, T, Yao, M, Kimura, A. | | 登録日 | 2018-01-05 | | 公開日 | 2019-05-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Structural insights reveal the second base catalyst of isomaltose glucohydrolase.
Febs J., 289, 2022
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5Z3A
 | | Glycosidase Wild Type | | 分子名称: | CITRIC ACID, GLYCEROL, Glycoside hydrolase 15-related protein | | 著者 | Tanaka, Y, Chen, M, Tagami, T, Yao, M, Kimura, A. | | 登録日 | 2018-01-05 | | 公開日 | 2019-05-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.401 Å) | | 主引用文献 | Structural insights reveal the second base catalyst of isomaltose glucohydrolase.
Febs J., 289, 2022
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5Z3E
 | | Glycosidase E335A | | 分子名称: | CITRIC ACID, GLYCEROL, Glycoside hydrolase 15-related protein | | 著者 | Tanaka, Y, Chen, M, Tagami, T, Yao, M, Kimura, A. | | 登録日 | 2018-01-05 | | 公開日 | 2019-05-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Structural insights reveal the second base catalyst of isomaltose glucohydrolase.
Febs J., 289, 2022
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5Z3F
 | | Glycosidase E335A in complex with glucose | | 分子名称: | CITRIC ACID, GLYCEROL, Glycoside hydrolase 15-related protein, ... | | 著者 | Tanaka, Y, Chen, M, Tagami, T, Yao, M, Kimura, A. | | 登録日 | 2018-01-05 | | 公開日 | 2019-05-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Structural insights reveal the second base catalyst of isomaltose glucohydrolase.
Febs J., 289, 2022
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