7SSE
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![BU of 7sse by Molmil](/molmil-images/mine/7sse) | Crystal structure of the WDR domain of human DCAF1 in complex with CYCA-117-70 | 分子名称: | DDB1- and CUL4-associated factor 1, N-[(3R)-1-(3-fluorophenyl)piperidin-3-yl]-6-(morpholin-4-yl)pyrimidin-4-amine | 著者 | Kimani, S, Owen, J, Li, A, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Shahani, V.M, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2021-11-10 | 公開日 | 2021-12-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Discovery of a Novel DCAF1 Ligand Using a Drug-Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets. J.Chem.Inf.Model., 63, 2023
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7T39
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![BU of 7t39 by Molmil](/molmil-images/mine/7t39) | Co-crystal structure of human PRMT9 in complex with MT221 inhibitor | 分子名称: | 7-[5-S-(4-{[(2-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Protein arginine N-methyltransferase 9 | 著者 | Zeng, H, Dong, A, Hutchinson, A, Seitova, A, Li, Y, Gao, Y.D, Schneider, S, Siliphaivanh, P, Sloman, D, Nicholson, B, Fischer, C, Hicks, J, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2021-12-07 | 公開日 | 2021-12-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Co-crystal structure of human PRMT9 in complex with MT221 inhibitor To Be Published
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7U9I
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![BU of 7u9i by Molmil](/molmil-images/mine/7u9i) | Co-crystal structure of human CARM1 in complex with MT556 inhibitor | 分子名称: | 7-[5-S-(4-{[(4-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Histone-arginine methyltransferase CARM1, UNKNOWN ATOM OR ION | 著者 | Zeng, H, Perveen, S, Dong, A, Hutchinson, A, Seitova, A, Gibson, E, Hajian, T, Li, Y, Gao, Y.D, Schneider, S, Siliphaivanh, P, Sloman, D, Nicholson, B, Fischer, C, Hicks, J, Vedadi, M, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2022-03-10 | 公開日 | 2023-01-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Co-crystal structure of human CARM1 in complex with MT556 inhibitor To Be Published
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7RUO
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![BU of 7ruo by Molmil](/molmil-images/mine/7ruo) | Crystal structure of human UTP15 | 分子名称: | U3 small nucleolar RNA-associated protein 15 homolog, UNKNOWN ATOM OR ION | 著者 | Dehghani-Tafti, S, Dong, A, Zeng, H, Hutchinson, A, Seitova, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2021-08-17 | 公開日 | 2021-11-10 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of human UTP15 To Be Published
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1VYH
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![BU of 1vyh by Molmil](/molmil-images/mine/1vyh) | PAF-AH Holoenzyme: Lis1/Alfa2 | 分子名称: | PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB ALPHA SUBUNIT, PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB BETA SUBUNIT | 著者 | Tarricone, C, Perrina, F, Monzani, S, Massimiliano, L, Knapp, S, Tsai, L.-H, Derewenda, Z.S, Musacchio, A. | 登録日 | 2004-04-30 | 公開日 | 2005-05-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Coupling Paf Signaling to Dynein Regulation: Structure of Lis1 in Complex with Paf-Acetylhydrolase. Neuron, 44, 2004
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4ODC
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![BU of 4odc by Molmil](/molmil-images/mine/4odc) | Crystal structure of Trematomus bernacchii hemoglobin in a partially cyanided state | 分子名称: | CYANIDE ION, GLYCEROL, Hemoglobin subunit alpha, ... | 著者 | Mazzarella, L, Merlino, A, Vitagliano, L, Vergara, A. | 登録日 | 2014-01-10 | 公開日 | 2014-12-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Structural modifications induced by the switch from an endogenous bis-histidyl to an exogenous cyanomet hexa-coordination in a tetrameric haemoglobin RSC ADV, 4, 2014
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4QBB
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![BU of 4qbb by Molmil](/molmil-images/mine/4qbb) | Structure of the foot-and-mouth disease virus leader proteinase in complex with inhibitor (N~2~-[(3S)-4-({(2R)-1-[(4-CARBAMIMIDAMIDOBUTYL)AMINO]-4-METHYL-1-OXOPENTAN-2-YL}AMINO)-3-HYDROXY-4-OXOBUTANOYL]-L-ARGINYL-L-PROLINAMIDE) | 分子名称: | Leader protease, N~2~-[(3S)-4-({(2R)-1-[(4-carbamimidamidobutyl)amino]-4-methyl-1-oxopentan-2-yl}amino)-3-hydroxy-4-oxobutanoyl]-L-arginyl-L-prolinamide, PHOSPHATE ION, ... | 著者 | Grishkovskaya, I, Steinberger, J, Cencic, R, Juliano, M.A, Juliano, L, Skern, T. | 登録日 | 2014-05-07 | 公開日 | 2014-11-05 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Foot-and-mouth disease virus leader proteinase: Structural insights into the mechanism of intermolecular cleavage. Virology, 468-470C, 2014
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4J5B
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![BU of 4j5b by Molmil](/molmil-images/mine/4j5b) | Human Cyclophilin D Complexed with an Inhibitor | 分子名称: | 1-(4-aminobenzyl)-3-(2-{(2R)-2-[2-(methylsulfanyl)phenyl]pyrrolidin-1-yl}-2-oxoethyl)urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial | 著者 | Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F. | 登録日 | 2013-02-08 | 公開日 | 2014-02-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nat Commun, 7, 2016
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4J59
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![BU of 4j59 by Molmil](/molmil-images/mine/4j59) | Human Cyclophilin D Complexed with an Inhibitor | 分子名称: | 1-(4-aminobenzyl)-3-{2-[(2R)-2-(naphthalen-1-yl)pyrrolidin-1-yl]-2-oxoethyl}urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial | 著者 | Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F. | 登録日 | 2013-02-08 | 公開日 | 2014-02-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nat Commun, 7, 2016
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4J5C
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![BU of 4j5c by Molmil](/molmil-images/mine/4j5c) | Human Cyclophilin D Complexed with an Inhibitor | 分子名称: | 1-(4-aminobenzyl)-3-[(2S)-4-(methylsulfanyl)-1-{(2R)-2-[2-(methylsulfanyl)phenyl]pyrrolidin-1-yl}-1-oxobutan-2-yl]urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial | 著者 | Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F. | 登録日 | 2013-02-08 | 公開日 | 2014-02-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | 主引用文献 | Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nat Commun, 7, 2016
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4J5E
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![BU of 4j5e by Molmil](/molmil-images/mine/4j5e) | Human Cyclophilin D Complexed with an Inhibitor | 分子名称: | 1-(4-aminobenzyl)-3-{2-[(2R)-2-(2-methoxyphenyl)pyrrolidin-1-yl]-2-oxoethyl}urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial | 著者 | Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F. | 登録日 | 2013-02-08 | 公開日 | 2014-02-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (0.99 Å) | 主引用文献 | Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nat Commun, 7, 2016
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4J5D
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![BU of 4j5d by Molmil](/molmil-images/mine/4j5d) | Human Cyclophilin D Complexed with an Inhibitor | 分子名称: | 1-(4-aminobenzyl)-3-{2-[(2R)-2-(2-bromophenyl)pyrrolidin-1-yl]-2-oxoethyl}urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial | 著者 | Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F. | 登録日 | 2013-02-08 | 公開日 | 2014-02-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nat Commun, 7, 2016
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4Q4N
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![BU of 4q4n by Molmil](/molmil-images/mine/4q4n) | Structure of the Resuscitation Promoting Factor Interacting protein RipA mutated at H432 | 分子名称: | Peptidoglycan endopeptidase RipA | 著者 | Squeglia, F, Ruggiero, A, Romano, M, Vitagliano, L, Berisio, R. | 登録日 | 2014-04-15 | 公開日 | 2014-09-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Mutational and structural study of RipA, a key enzyme in Mycobacterium tuberculosis cell division: evidence for the L-to-D inversion of configuration of the catalytic cysteine. Acta Crystallogr.,Sect.D, 70, 2014
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4Q4T
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![BU of 4q4t by Molmil](/molmil-images/mine/4q4t) | Structure of the Resuscitation Promoting Factor Interacting protein RipA mutated at E444 | 分子名称: | FORMIC ACID, GLYCEROL, Peptidoglycan endopeptidase RipA | 著者 | Squeglia, F, Ruggiero, A, Romano, M, Vitagliano, L, Berisio, R. | 登録日 | 2014-04-15 | 公開日 | 2014-09-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Mutational and structural study of RipA, a key enzyme in Mycobacterium tuberculosis cell division: evidence for the L-to-D inversion of configuration of the catalytic cysteine. Acta Crystallogr.,Sect.D, 70, 2014
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4PSH
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![BU of 4psh by Molmil](/molmil-images/mine/4psh) | Structure of holo ArgBP from T. maritima | 分子名称: | ABC-type transporter, periplasmic subunit family 3, ARGININE | 著者 | Ruggiero, A, Dattelbaum, J.D, Staiano, M, Berisio, R, D'Auria, S, Vitagliano, L. | 登録日 | 2014-03-07 | 公開日 | 2014-07-23 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima Plos One, 9, 2014
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4PRS
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![BU of 4prs by Molmil](/molmil-images/mine/4prs) | Structure of apo ArgBP from T. maritima | 分子名称: | ABC-type transporter, periplasmic subunit family 3 | 著者 | Ruggiero, A, Dattelbaum, J.D, Staiano, M, Berisio, R, D'Auria, S, Vitagliano, L. | 登録日 | 2014-03-06 | 公開日 | 2014-07-23 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima Plos One, 9, 2014
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3QYU
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![BU of 3qyu by Molmil](/molmil-images/mine/3qyu) | Crystal structure of human cyclophilin D at 1.54 A resolution at room temperature | 分子名称: | Peptidyl-prolyl cis-trans isomerase F | 著者 | Colliandre, L, Gelin, M, Labesse, G, Guichou, J.-F. | 登録日 | 2011-03-04 | 公開日 | 2011-08-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | In-plate protein crystallization, in situ ligand soaking and X-ray diffraction. Acta Crystallogr.,Sect.D, 67, 2011
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5AEQ
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![BU of 5aeq by Molmil](/molmil-images/mine/5aeq) | Neuronal calcium sensor (NCS-1)from Rattus norvegicus | 分子名称: | CALCIUM ION, NEURONAL CALCIUM SENSOR 1, SODIUM ION | 著者 | Saleem, M, Karuppiah, V, Pandalaneni, S, Burgoyne, R, Derrick, J.P, Lian, L.Y. | 登録日 | 2015-01-08 | 公開日 | 2015-02-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-Protein-Coupled Receptor Kinase 1 (Grk1) Peptides Using Different Modes of Interactions. J.Biol.Chem., 290, 2015
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2LNS
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![BU of 2lns by Molmil](/molmil-images/mine/2lns) | Solution structure of AGR2 residues 41-175 | 分子名称: | Anterior gradient protein 2 homolog | 著者 | Patel, P, Clarke, C.J, Barraclough, D.L, Rudland, P.S, Barraclough, R, Lian, L. | 登録日 | 2012-01-04 | 公開日 | 2013-01-09 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion. J.Mol.Biol., 425, 2013
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2LV7
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![BU of 2lv7 by Molmil](/molmil-images/mine/2lv7) | Solution structure of Ca2+-bound CaBP7 N-terminal doman | 分子名称: | CALCIUM ION, Calcium-binding protein 7 | 著者 | Mccue, H.V, Patel, P, Herbert, A.P, Lian, L, Burgoyne, R.D, Haynes, L.P. | 登録日 | 2012-06-29 | 公開日 | 2012-09-26 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR Structure of the Ca2+-bound N-terminal Domain of CaBP7: A REGULATOR OF GOLGI TRAFFICKING. J.Biol.Chem., 287, 2012
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5AER
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![BU of 5aer by Molmil](/molmil-images/mine/5aer) | Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with D2 dopamine receptor peptide from Homo sapiens | 分子名称: | CALCIUM ION, D(2) DOPAMINE RECEPTOR, NEURONAL CALCIUM SENSOR 1, ... | 著者 | Saleem, M, Karuppiah, V, Pandalaneni, S, Burgoyne, R, Derrick, J.P, Lian, L.Y. | 登録日 | 2015-01-08 | 公開日 | 2015-02-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-Protein-Coupled Receptor Kinase 1 (Grk1) Peptides Using Different Modes of Interactions. J.Biol.Chem., 290, 2015
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1FT0
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![BU of 1ft0 by Molmil](/molmil-images/mine/1ft0) | CRYSTAL STRUCTURE OF TRUNCATED HUMAN RHOGDI K113A MUTANT | 分子名称: | RHO GDP-DISSOCIATION INHIBITOR 1 | 著者 | Longenecker, K.L, Garrard, S.M, Sheffield, P.J, Derewenda, Z.S. | 登録日 | 2000-09-11 | 公開日 | 2001-05-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI. Acta Crystallogr.,Sect.D, 57, 2001
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1FT3
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![BU of 1ft3 by Molmil](/molmil-images/mine/1ft3) | CRYSTAL STRUCTURE OF TRUNCATED RHOGDI K141A MUTANT | 分子名称: | RHO GDP-DISSOCIATION INHIBITOR 1 | 著者 | Longenecker, K.L, Garrard, S.M, Sheffield, P.J, Derewenda, Z.S. | 登録日 | 2000-09-11 | 公開日 | 2001-05-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI. Acta Crystallogr.,Sect.D, 57, 2001
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1FST
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![BU of 1fst by Molmil](/molmil-images/mine/1fst) | CRYSTAL STRUCTURE OF TRUNCATED HUMAN RHOGDI TRIPLE MUTANT | 分子名称: | RHO GDP-DISSOCIATION INHIBITOR 1 | 著者 | Longenecker, K.L, Garrard, S.M, Sheffield, P.J, Derewenda, Z.S. | 登録日 | 2000-09-11 | 公開日 | 2001-05-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI. Acta Crystallogr.,Sect.D, 57, 2001
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2LNT
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![BU of 2lnt by Molmil](/molmil-images/mine/2lnt) | Solution structure of E60A mutant AGR2 | 分子名称: | Anterior gradient protein 2 homolog | 著者 | Patel, P, Clarke, C.J, Barraclough, D.L, Rudland, P.S, Barraclough, R, Lian, L. | 登録日 | 2012-01-04 | 公開日 | 2013-01-09 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion. J.Mol.Biol., 425, 2013
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