8BG9
| Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta | 分子名称: | Amyloid-beta protein 40 | 著者 | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | 登録日 | 2022-10-27 | 公開日 | 2023-01-18 | 最終更新日 | 2023-02-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
|
|
1RQC
| Crystals of peptide deformylase from Plasmodium falciparum with ten subunits per asymmetric unit reveal critical characteristics of the active site for drug design | 分子名称: | COBALT (II) ION, formylmethionine deformylase | 著者 | Robien, M.A, Nguyen, K.T, Kumar, A, Hirsh, I, Turley, S, Pei, D, Hol, W.G. | 登録日 | 2003-12-04 | 公開日 | 2004-01-20 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | An improved crystal form of Plasmodium falciparum peptide deformylase Protein Sci., 13, 2004
|
|
8BFZ
| Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42 | 分子名称: | Amyloid-beta precursor protein | 著者 | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordberg, A, Goedert, M, Scheres, S.H.W. | 登録日 | 2022-10-27 | 公開日 | 2023-01-18 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
|
|
3P20
| Crystal structure of vanadate bound subunit A of the A1AO ATP synthase | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETIC ACID, ... | 著者 | Manimekalai, M.S.S, Kumar, A, Jeyakanthan, J, Gruber, G. | 登録日 | 2010-10-01 | 公開日 | 2011-03-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | The transition-like state and Pi entrance into the catalytic a subunit of the biological engine A-ATP synthase. J.Mol.Biol., 408, 2011
|
|
3QG1
| Crystal structure of P-loop G239A mutant of subunit A of the A1AO ATP synthase | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, V-type ATP synthase alpha chain | 著者 | Ragunathan, P, Manimekalai, M.S.S, Kumar, A, Jeyakanthan, J, Gruber, G. | 登録日 | 2011-01-24 | 公開日 | 2011-10-05 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Conserved glycine residues in the P-loop of ATP synthases form a doorframe for nucleotide entrance. J.Mol.Biol., 413, 2011
|
|
5HWK
| Crystal structure of gama glutamyl cyclotransferease specific to glutathione from yeast | 分子名称: | BENZOIC ACID, Glutathione-specific gamma-glutamylcyclotransferase, PHOSPHATE ION | 著者 | Kaur, A, Gautam, R, Srivastava, R, Chandel, A, Kumar, A, Karthikeyan, S, Bachhawat, A.K. | 登録日 | 2016-01-29 | 公開日 | 2016-12-14 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.344 Å) | 主引用文献 | ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione J. Biol. Chem., 292, 2017
|
|
5HWI
| Crystal structure of selenomethionine labelled gama glutamyl cyclotransferease specific to glutathione from yeast | 分子名称: | GLYCEROL, Glutathione-specific gamma-glutamylcyclotransferase, SUCCINIC ACID | 著者 | Kaur, A, Gautam, R, Srivastava, R, Chandel, A, Kumar, A, Karthikeyan, S, Bachhawat, A.K. | 登録日 | 2016-01-29 | 公開日 | 2016-12-14 | 最終更新日 | 2017-01-25 | 実験手法 | X-RAY DIFFRACTION (1.755 Å) | 主引用文献 | ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione J. Biol. Chem., 292, 2017
|
|
2BPG
| STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP | 分子名称: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*GP*CP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*CP*GP*CP*CP*G)-3'), ... | 著者 | Pelletier, H, Sawaya, M.R, Kumar, A, Wilson, S.H, Kraut, J. | 登録日 | 1994-05-19 | 公開日 | 1994-08-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP. Science, 264, 1994
|
|
2BPF
| STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP | 分子名称: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*GP*CP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*CP*GP*CP*CP*G)-3'), ... | 著者 | Pelletier, H, Sawaya, M.R, Kumar, A, Wilson, S.H, Kraut, J. | 登録日 | 1994-05-19 | 公開日 | 1994-12-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP. Science, 264, 1994
|
|
5XYL
| |
4B2Z
| Structure of Osh6 in complex with phosphatidylserine | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, ... | 著者 | Maeda, K, Anand, K, Chiapparino, A, Kumar, A, Poletto, M, Kaksonen, M, Gavin, A.C. | 登録日 | 2012-07-19 | 公開日 | 2013-06-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Interactome Map Uncovers Phosphatidylserine Transport by Oxysterol-Binding Proteins Nature, 501, 2013
|
|
7TU9
| Alpha1/BetaB Heteromeric Glycine Receptor in Strychnine-Bound State | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor beta subunit 2, ... | 著者 | Gibbs, E, Kumar, A, Chakrapani, S. | 登録日 | 2022-02-02 | 公開日 | 2023-03-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Conformational transitions and allosteric modulation in a heteromeric glycine receptor Nat Commun, 14, 2023
|
|
7TVI
| Alpha1/BetaB Heteromeric Glycine Receptor in Glycine-Bound State | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor beta subunit 2, ... | 著者 | Gibbs, E, Chakrapani, S, Kumar, A. | 登録日 | 2022-02-04 | 公開日 | 2023-03-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Conformational transitions and allosteric modulation in a heteromeric glycine receptor Nat Commun, 14, 2023
|
|
4JC4
| Crystal structure of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa at 2.25 angstrom resolution | 分子名称: | GLYCEROL, Peptidyl-tRNA hydrolase | 著者 | Singh, A, Kumar, A, Sinha, M, Bhushan, A, Kaur, P, Sharma, S, Arora, A, Singh, T.P. | 登録日 | 2013-02-21 | 公開日 | 2013-04-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure-based inhibitor design against peptidyl-tRNA hydrolase Biochem.J., 463, 2014
|
|
5IQY
| Structure of apo-Dehydroascorbate Reductase from Pennisetum Glaucum phased by Iodide-SAD method | 分子名称: | Dehydroascorbate reductase, IODIDE ION | 著者 | Das, B.K, Kumar, A, Manidola, P, Arockiasamy, A. | 登録日 | 2016-03-11 | 公開日 | 2016-05-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Non-native ligands define the active site of Pennisetum glaucum (L.) R. Br dehydroascorbate reductase Biochem.Biophys.Res.Commun., 473, 2016
|
|
1FMQ
| Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG | 分子名称: | 2,5-BIS{[4-(N-CYCLOBUTYLDIAMINOMETHYL)PHENYL]}FURAN, 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION | 著者 | Simpson, I.J, Lee, M, Kumar, A, Boykin, D.W, Neidle, S. | 登録日 | 2000-08-18 | 公開日 | 2000-09-11 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | DNA minor groove interactions and the biological activity of 2,5-bis-[4-(N-alkylamidino)phenyl] furans Bioorg.Med.Chem.Lett., 10, 2000
|
|
1FMS
| Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG) | 分子名称: | 2,5-BIS{[4-(N-CYCLOHEXYLDIAMINOMETHYL)PHENYL]}FURAN, 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION | 著者 | Simpson, I.J, Lee, M, Kumar, A, Boykin, D.W, Neidle, S. | 登録日 | 2000-08-18 | 公開日 | 2000-09-11 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | DNA minor groove interactions and the biological activity of 2,5-bis-[4-(N-alkylamidino)phenyl] furans Bioorg.Med.Chem.Lett., 10, 2000
|
|
7D5L
| Discovery of BMS-986144, a Third Generation, Pan Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection | 分子名称: | NS3/4A Protease, ZINC ION, [1,1,1-tris(fluoranyl)-2-methyl-propan-2-yl] ~{N}-[(1~{S},4~{R},6~{S},7~{Z},11~{R},13~{R},14~{S},18~{R})-13-ethyl-18-(7-fluoranyl-6-methoxy-isoquinolin-1-yl)oxy-11-methyl-4-[(1-methylcyclopropyl)sulfonylcarbamoyl]-2,15-bis(oxidanylidene)-3,16-diazatricyclo[14.3.0.0^{4,6}]nonadec-7-en-14-yl]carbamate | 著者 | Ghosh, K, Anumula, R, Kumar, A. | 登録日 | 2020-09-26 | 公開日 | 2020-12-16 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J.Med.Chem., 63, 2020
|
|
6IGR
| Crystal structure of S9 peptidase (S514A mutant in inactive state) from Deinococcus radiodurans R1 | 分子名称: | Acyl-peptide hydrolase, putative, GLYCEROL | 著者 | Yadav, P, Gaur, N.K, Goyal, V.D, Kumar, A, Makde, R.D. | 登録日 | 2018-09-25 | 公開日 | 2018-11-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Carboxypeptidase in prolyl oligopeptidase family: Unique enzyme activation and substrate-screening mechanisms. J.Biol.Chem., 294, 2019
|
|
6IGP
| Crystal structure of S9 peptidase (inactive state)from Deinococcus radiodurans R1 in P212121 | 分子名称: | Acyl-peptide hydrolase, putative, GLYCEROL | 著者 | Yadav, P, Goyal, V.D, Kumar, A, Makde, R.D. | 登録日 | 2018-09-25 | 公開日 | 2018-11-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Carboxypeptidase in prolyl oligopeptidase family: Unique enzyme activation and substrate-screening mechanisms. J.Biol.Chem., 294, 2019
|
|
6IGQ
| Crystal structure of inactive state of S9 peptidase from Deinococcus radiodurans R1 (PMSF treated) | 分子名称: | Acyl-peptide hydrolase, putative, GLYCEROL, ... | 著者 | Yadav, P, Goyal, V.D, Kumar, A, Makde, R.D. | 登録日 | 2018-09-25 | 公開日 | 2018-11-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Carboxypeptidase in prolyl oligopeptidase family: Unique enzyme activation and substrate-screening mechanisms. J.Biol.Chem., 294, 2019
|
|
6IKG
| Crystal structure of substrate-bound S9 peptidase (S514A mutant) from Deinococcus radiodurans | 分子名称: | Acyl-peptide hydrolase, putative, GLYCEROL, ... | 著者 | Yadav, P, Kumar, A, Goyal, V.D, Makde, R.D. | 登録日 | 2018-10-16 | 公開日 | 2018-11-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Carboxypeptidase in prolyl oligopeptidase family: Unique enzyme activation and substrate-screening mechanisms. J.Biol.Chem., 294, 2019
|
|
8HMR
| Crystal Structure of PKM2 mutant L144P | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ... | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | 登録日 | 2022-12-05 | 公開日 | 2023-01-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
|
|
8HMU
| Crystal Structure of PKM2 mutant R516C | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | 登録日 | 2022-12-05 | 公開日 | 2023-01-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
|
|
8HMS
| Crystal Structure of PKM2 mutant C474S | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | 登録日 | 2022-12-05 | 公開日 | 2023-01-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
|
|