7N3O
 
 | | Cryo-EM structure of the Cas12k-sgRNA complex | | 分子名称: | Cas12k, Single guide RNA | | 著者 | Chang, L, Li, Z, Xiao, R, Wang, S, Han, R. | | 登録日 | 2021-06-01 | | 公開日 | 2021-09-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition.
Mol.Cell, 81, 2021
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7N3P
 | | Cryo-EM structure of the Cas12k-sgRNA-dsDNA complex | | 分子名称: | Cas12k, DNA (5'-D(*CP*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*AP*AP*CP*CP*GP*AP*GP*TP*TP*T)-3'), DNA (5'-D(P*AP*AP*AP*CP*TP*CP*GP*GP*TP*T)-3'), ... | | 著者 | Chang, L, Li, Z, Xiao, R, Wang, S, Han, R. | | 登録日 | 2021-06-01 | | 公開日 | 2021-09-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | | 主引用文献 | Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition.
Mol.Cell, 81, 2021
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5U8M
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5VFA
 | | RitR Mutant - C128D | | 分子名称: | Response regulator | | 著者 | Han, L, Silvaggi, N.R. | | 登録日 | 2017-04-07 | | 公開日 | 2018-04-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.452 Å) | | 主引用文献 | RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization.
PLoS Pathog., 14, 2018
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7L48
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7L49
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6DA6
 | | Crystal structure of the TtnD decarboxylase from the tautomycetin biosynthesis pathway of Streptomyces griseochromogenes, apo form at 2.6 A resolution (P212121) | | 分子名称: | GLYCEROL, MAGNESIUM ION, UNKNOWN LIGAND, ... | | 著者 | Han, L, Rudolf, J.D, Chang, C.-Y, Miller, M.D, Soman, J, Phillips Jr, G.N, Shen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2018-05-01 | | 公開日 | 2018-10-03 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.
ACS Chem. Biol., 13, 2018
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6DA7
 | | Crystal structure of the TtnD decarboxylase from the tautomycetin biosynthesis pathway of Streptomyces griseochromogenes with apo form at 1.83 A resolution (I222) | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, SODIUM ION, ... | | 著者 | Han, L, Rudolf, J.D, Chang, C.-Y, Miller, M.D, Soman, J, Phillips Jr, G.N, Shen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2018-05-01 | | 公開日 | 2018-10-03 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.
ACS Chem. Biol., 13, 2018
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6DA9
 | | Crystal structure of the TtnD decarboxylase from the tautomycetin biosynthesis pathway of Streptomyces griseochromogenes with FMN bound at 2.05 A resolution | | 分子名称: | FLAVIN MONONUCLEOTIDE, GLYCEROL, MANGANESE (II) ION, ... | | 著者 | Han, L, Rudolf, J.D, Chang, C.-Y, Miller, M.D, Soman, J, Xu, W, Phillips Jr, G.N, Shen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2018-05-01 | | 公開日 | 2018-10-03 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.
ACS Chem. Biol., 13, 2018
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5DJ3
 | | Structure of the PLP-Dependent L-Arginine Hydroxylase MppP with D-Arginine Bound | | 分子名称: | (E)-N~2~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-D-arginine, MAGNESIUM ION, PLP-Dependent L-Arginine Hydroxylase MppP | | 著者 | Silvaggi, N.R, Han, L. | | 登録日 | 2015-09-01 | | 公開日 | 2015-11-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.227 Å) | | 主引用文献 | Streptomyces wadayamensis MppP Is a Pyridoxal 5'-Phosphate-Dependent l-Arginine alpha-Deaminase, gamma-Hydroxylase in the Enduracididine Biosynthetic Pathway.
Biochemistry, 54, 2015
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5DJ1
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7OQ6
 | | Crystal structure of cytochrome P450 Sas16 from Streptomyces asterosporus | | 分子名称: | Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, THIOCYANATE ION | | 著者 | Zhang, L, Zhang, S, Bechthold, A, Einsle, O. | | 登録日 | 2021-06-02 | | 公開日 | 2022-06-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate.
Acta Pharm Sin B, 13, 2023
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7N7V
 | | Crystal structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in Streptomyces griseochromogenes at 2 A. | | 分子名称: | CHLORIDE ION, FE (II) ION, Predicted hydroxylase | | 著者 | Han, L, Xu, W, Ma, M, Miller, M.D, Shen, B, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2021-06-11 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in Streptomyces griseochromogenes.
To Be Published
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6W62
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6W5C
 | | Cryo-EM structure of Cas12i(E894A)-crRNA-dsDNA complex | | 分子名称: | Cas12i, NTS, Substrate, ... | | 著者 | Chang, L, Li, Z, Zhang, H. | | 登録日 | 2020-03-13 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease.
Nat.Struct.Mol.Biol., 27, 2020
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6W64
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6NMA
 | | CryoEM structure of the LbCas12a-crRNA-AcrVA4 complex | | 分子名称: | AcrVA1, Cpf1, MAGNESIUM ION, ... | | 著者 | Chang, L, Li, Z, Zhang, H. | | 登録日 | 2019-01-10 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins.
Cell Host Microbe, 25, 2019
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6NMD
 | | cryo-EM Structure of the LbCas12a-crRNA-AcrVA1 complex | | 分子名称: | AcrVA1, Cpf1, MAGNESIUM ION, ... | | 著者 | Chang, L, Li, Z, Zhang, H. | | 登録日 | 2019-01-10 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins.
Cell Host Microbe, 25, 2019
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6NM9
 | | CryoEM structure of the LbCas12a-crRNA-AcrVA4 dimer | | 分子名称: | AcrVA4, Cpf1, MAGNESIUM ION, ... | | 著者 | Chang, L, Li, Z, Zhang, H. | | 登録日 | 2019-01-10 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins.
Cell Host Microbe, 25, 2019
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6NME
 | | Structure of LbCas12a-crRNA | | 分子名称: | Cpf1, MAGNESIUM ION, crRNA | | 著者 | Chang, L, Li, Z, Zhang, H. | | 登録日 | 2019-01-10 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (5.67 Å) | | 主引用文献 | Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins.
Cell Host Microbe, 25, 2019
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6NMC
 | | CryoEM structure of the LbCas12a-crRNA-2xAcrVA1 complex | | 分子名称: | AcrVA1, Cpf1, MAGNESIUM ION, ... | | 著者 | Chang, L, Li, Z, Zhang, H. | | 登録日 | 2019-01-10 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.24 Å) | | 主引用文献 | Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins.
Cell Host Microbe, 25, 2019
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6OMV
 | | CryoEM structure of the LbCas12a-crRNA-AcrVA4-DNA complex | | 分子名称: | AcrVA4, Cpf1, DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*GP*GP*A)-3'), ... | | 著者 | Chang, L, Li, Z, Zhang, H. | | 登録日 | 2019-04-19 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins.
Cell Host Microbe, 25, 2019
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4Y0K
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4XO1
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6UVN
 | | CryoEM structure of VcCascasde-TniQ complex | | 分子名称: | Cas6, Cas7, Cas8/5, ... | | 著者 | Chang, L, Li, Z, Zhang, H. | | 登録日 | 2019-11-03 | | 公開日 | 2020-01-29 | | 最終更新日 | 2020-02-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cryo-EM structure of a type I-F CRISPR RNA guided surveillance complex bound to transposition protein TniQ.
Cell Res., 30, 2020
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