5GOE
 
 | | Truncated mitofusin-1, GDP-bound | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Mitofusin-1 | | 著者 | Cao, Y.L, Gao, S. | | 登録日 | 2016-07-26 | | 公開日 | 2017-01-25 | | 最終更新日 | 2017-03-08 | | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | | 主引用文献 | MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion
Nature, 542, 2017
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5EDQ
 | | EGFR kinase (T790M/L858R) with inhibitor compound 15: ~{N}-(7-chloranyl-1~{H}-indazol-3-yl)-7,7-dimethyl-2-(1~{H}-pyrazol-4-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine | | 分子名称: | Epidermal growth factor receptor, ~{N}-(7-chloranyl-1~{H}-indazol-3-yl)-7,7-dimethyl-2-(1~{H}-pyrazol-4-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine | | 著者 | Eigenbrot, C, Yu, C. | | 登録日 | 2015-10-21 | | 公開日 | 2015-12-02 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | 4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.
Bioorg.Med.Chem.Lett., 26, 2016
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5EM7
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8WI0
 | | wt-hMRP5 inward-open | | 分子名称: | ATP-binding cassette sub-family C member 5 | | 著者 | Liu, Z.M, Huang, Y. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5.
Nat Commun, 15, 2024
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5GO4
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5GOF
 | | Truncated mitofusin-1, GTP-bound | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mitofusin-1, ... | | 著者 | Cao, Y.L, Gao, S. | | 登録日 | 2016-07-26 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.604 Å) | | 主引用文献 | MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion
Nature, 542, 2017
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7ESC
 | | FmnB complexed with AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, FAD:protein FMN transferase, MAGNESIUM ION | | 著者 | Cheng, W, Zheng, Y.H. | | 登録日 | 2021-05-10 | | 公開日 | 2021-11-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | | 主引用文献 | Structural insights into the catalytic and inhibitory mechanisms of the flavin transferase FmnB in Listeria monocytogenes.
MedComm (2020), 3, 2022
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7ESA
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7ESB
 | | FmnB complexed with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, FAD:protein FMN transferase, MAGNESIUM ION | | 著者 | Zheng, Y.H, Cheng, W. | | 登録日 | 2021-05-09 | | 公開日 | 2021-11-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural insights into the catalytic and inhibitory mechanisms of the flavin transferase FmnB in Listeria monocytogenes.
MedComm (2020), 3, 2022
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7F39
 | | The structure of flavin transferase FmnB | | 分子名称: | FAD:protein FMN transferase | | 著者 | Cheng, W, Zheng, Y.H. | | 登録日 | 2021-06-15 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.888 Å) | | 主引用文献 | Structural insights into the catalytic and inhibitory mechanisms of the flavin transferase FmnB in Listeria monocytogenes.
MedComm (2020), 3, 2022
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7F2U
 | | FmnB complexed with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, FAD:protein FMN transferase, MAGNESIUM ION | | 著者 | Cheng, W, Zheng, Y.H. | | 登録日 | 2021-06-14 | | 公開日 | 2021-11-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.984 Å) | | 主引用文献 | Structural insights into the catalytic and inhibitory mechanisms of the flavin transferase FmnB in Listeria monocytogenes.
MedComm (2020), 3, 2022
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8WI5
 | | M5PI-bound hMRP5 | | 分子名称: | ATP-binding cassette sub-family C member 5 | | 著者 | Liu, Z.M, Huang, Y. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5.
Nat Commun, 15, 2024
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8WI2
 | | RD-hMRP5-inward open | | 分子名称: | ATP-binding cassette sub-family C member 5, CYS-GLN-ASP-ALA-LEU-GLU-THR-ALA-ALA-ARG-ALA-GLU-GLY-LEU-SER-LEU-ASP-ALA-SER | | 著者 | Liu, Z.M, Huang, Y. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (4.06 Å) | | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5.
Nat Commun, 15, 2024
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8WI3
 | | ND-hMRP5-inward open | | 分子名称: | ATP-binding cassette sub-family C member 5 | | 著者 | Liu, Z.M, Huang, Y. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5.
Nat Commun, 15, 2024
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8WI4
 | | m6-hMRP5 inward open | | 分子名称: | ATP-binding cassette sub-family C member 5 | | 著者 | Liu, Z.M, Huang, Y. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5.
Nat Commun, 15, 2024
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7CYD
 | | Cryo-EM structures of Alphacoronavirus spike glycoprotein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Song, X, Shi, Y, Ding, W, Liu, Z.J, Peng, G. | | 登録日 | 2020-09-03 | | 公開日 | 2020-12-23 | | 最終更新日 | 2021-06-02 | | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | | 主引用文献 | Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes.
Nat Commun, 12, 2021
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5H3B
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5GOM
 | | Truncated mitofusin-1, transition-like state | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GUANOSINE-5'-DIPHOSPHATE, Mitofusin-1 | | 著者 | Cao, Y.L, Gao, S. | | 登録日 | 2016-07-27 | | 公開日 | 2017-02-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.802 Å) | | 主引用文献 | MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion
Nature, 542, 2017
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6JYJ
 | | Crystal structure of FAM46B (TENT5B) | | 分子名称: | CITRATE ANION, Terminal nucleotidyltransferase 5B | | 著者 | Zhang, H, Hu, J.L, Gao, S. | | 登録日 | 2019-04-26 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.693199 Å) | | 主引用文献 | FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Nucleic Acids Res., 48, 2020
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3HKS
 | | Crystal structure of eukaryotic translation initiation factor eIF-5A2 from Arabidopsis thaliana | | 分子名称: | 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 5A-2 | | 著者 | Teng, Y.B, He, Y.X, Jiang, Y.L, Chen, Y.X, Zhou, C.Z. | | 登録日 | 2009-05-25 | | 公開日 | 2009-09-29 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of Arabidopsis translation initiation factor eIF-5A2
Proteins, 77, 2009
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7JV9
 | | Human CD73 (ecto 5'-nucleotidase) in complex with compound 12 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-nucleotidase, 6-chloro-N-[(2-chlorophenyl)methyl]-1-[5-O-(phosphonomethyl)-beta-D-ribofuranosyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, ... | | 著者 | Gibbons, P, Du, X. | | 登録日 | 2020-08-20 | | 公開日 | 2020-09-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production.
J.Med.Chem., 63, 2020
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7JV8
 | | Human CD73 (ecto 5'-nucleotidase) in complex with compound 35 | | 分子名称: | 5'-nucleotidase, 6-chloro-N-cyclopentyl-1-{5-O-[(2R)-1-hydroxy-3-methoxy-2-phosphonopropan-2-yl]-beta-D-ribofuranosyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, ... | | 著者 | Gibbons, P, Du, X. | | 登録日 | 2020-08-20 | | 公開日 | 2020-09-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production.
J.Med.Chem., 63, 2020
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1VBS
 | | STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE | | 分子名称: | CYCLOPHILIN A, TETRAPEPTIDE | | 著者 | Zhao, Y, Chen, Y, Schutkowski, M, Fischer, G, Ke, H. | | 登録日 | 1998-06-16 | | 公開日 | 1999-01-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Mapping the stereospecificity of peptidyl prolyl cis/trans isomerases.
FEBS Lett., 432, 1998
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4FAA
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7TZO
 | | The apo structure of human mTORC2 complex | | 分子名称: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | | 著者 | Yu, Z, Chen, J, Pearce, D. | | 登録日 | 2022-02-16 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
J.Biol.Chem., 298, 2022
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