5EM7

EGFR kinase domain mutant "TMLR" with pyridone compound 13: 4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide

Summary for 5EM7

Entry DOI	10.2210/pdb5em7/pdb
Related	5EM5 5EM6 5EM8
Descriptor	Epidermal growth factor receptor, SULFATE ION, 4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide (3 entities in total)
Functional Keywords	protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	38078.96
Authors	Eigenbrot, C.,Yu, C. (deposition date: 2015-11-05, release date: 2015-12-30, Last modification date: 2024-03-06)
Primary citation	Bryan, M.C.,Burdick, D.J.,Chan, B.K.,Chen, Y.,Clausen, S.,Dotson, J.,Eigenbrot, C.,Elliott, R.,Hanan, E.J.,Heald, R.,Jackson, P.,La, H.,Lainchbury, M.,Malek, S.,Mann, S.E.,Purkey, H.E.,Schaefer, G.,Schmidt, S.,Seward, E.,Sideris, S.,Wang, S.,Yen, I.,Yu, C.,Heffron, T.P. Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR. Acs Med.Chem.Lett., 7:100-104, 2016 Cited by PubMed: 26819674 DOI: 10.1021/acsmedchemlett.5b00428 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.81 Å)

Structure validation