8TR4
| Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor X20404 | 分子名称: | 4-(2-{(4M)-4-[(6M)-6-(2,5-dimethoxyphenyl)pyridin-3-yl]-1H-1,2,3-triazol-1-yl}ethyl)-N,N-dimethylbenzamide, Polyketide synthase Pks13, SULFATE ION | 著者 | Krieger, I.V, Sacchettini, J.C. | 登録日 | 2023-08-09 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening. Acs Infect Dis., 10, 2024
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6M6C
| CryoEM structure of Thermus thermophilus RNA polymerase elongation complex | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Shi, J, Wen, A, Feng, Y. | 登録日 | 2020-03-14 | 公開日 | 2020-10-14 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of Mfd-dependent transcription termination. Nucleic Acids Res., 48, 2020
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8SHJ
| Crystal structure of the WD-repeat domain of human WDR91 in complex with MR45279 | 分子名称: | N-[3-(4-chlorophenyl)oxetan-3-yl]-4-[(3S)-3-hydroxypyrrolidin-1-yl]benzamide, WD repeat-containing protein 91 | 著者 | Ahmad, H, Zeng, H, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Xu, J, Feng, J.W, Brown, P.J, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2023-04-14 | 公開日 | 2023-07-05 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning. J.Med.Chem., 66, 2023
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6MIN
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6MIM
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8IX3
| Cryo-EM structure of SARS-CoV-2 BA.4/5 spike protein in complex with 1G11 (local refinement) | 分子名称: | BA.4/5 variant spike protein, heavy chain of 1G11, light chain of 1G11 | 著者 | Sun, H, Jiang, Y, Zheng, Z, Zheng, Q, Li, S. | 登録日 | 2023-03-31 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant. J.Virol., 97, 2023
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6MIO
| Crystal structure of Taf14 YEATS domain in complex with histone H3K9pr | 分子名称: | Histone H3K9pr, Transcription initiation factor TFIID subunit 14 | 著者 | Klein, B.J, Andrews, F.H, Vann, K.R, Kutateladze, T.G. | 登録日 | 2018-09-19 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain. Nat Commun, 9, 2018
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6MIQ
| Crystal structure of Taf14 YEATS domain in complex with histone H3K9bu | 分子名称: | Histone H3K9bu, Transcription initiation factor TFIID subunit 14 | 著者 | Klein, B.J, Andrews, F.H, Vann, K.R, Kutateladze, T.G. | 登録日 | 2018-09-19 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain. Nat Commun, 9, 2018
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6MIP
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7KN3
| Crystal structure of SARS-CoV-2 spike protein receptor-binding domain complexed with a pre-pandemic antibody S-B8 Fab | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, S-B8 Fab heavy chain, ... | 著者 | Liu, H, Zhu, X, Wilson, I.A. | 登録日 | 2020-11-04 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.251 Å) | 主引用文献 | Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago. Adv Sci, 9, 2022
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7KN4
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2IC8
| Crystal structure of GlpG | 分子名称: | Protein glpG, nonyl beta-D-glucopyranoside | 著者 | Ha, Y. | 登録日 | 2006-09-12 | 公開日 | 2006-10-17 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of a rhomboid family intramembrane protease. Nature, 444, 2006
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6MIL
| Crystal structure of AF9 YEATS domain in complex with histone H3K9bu | 分子名称: | DI(HYDROXYETHYL)ETHER, Histone H3K9bu, MALONATE ION, ... | 著者 | Vann, K.R, Klein, B.J, Kutateladze, T.G. | 登録日 | 2018-09-19 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain. Nat Commun, 9, 2018
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8T55
| Co-crystal structure of the WD-repeat domain of human WDR91 in complex with MR46654 | 分子名称: | 1,2-ETHANEDIOL, N-[3-(4-chlorophenyl)oxetan-3-yl]-1-propanoyl-1,2,3,4-tetrahydroquinoline-5-carboxamide, WD repeat-containing protein 91 | 著者 | Ahmad, H, Zeng, H, Dong, A, Li, Y, Yen, H, Seitova, A, Xu, J, Feng, J.W, Brown, P.J, Santhakumar, V, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2023-06-12 | 公開日 | 2023-07-05 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning. J.Med.Chem., 66, 2023
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5K86
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7P0Z
| 2.43 A Mycobacterium marinum EspB. | 分子名称: | ESX-1 secretion-associated protein EspB | 著者 | Gijsbers, A, Zhang, Y, Vinciauskaite, V, Siroy, A, Ye, G, Tria, G, Mathew, A, Sanchez-Puig, N, Lopez-Iglesias, C, Peters, P.J, Ravelli, R.B.G. | 登録日 | 2021-07-01 | 公開日 | 2021-08-18 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | Priming mycobacterial ESX-secreted protein B to form a channel-like structure. Curr Res Struct Biol, 3, 2021
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7LRT
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8K46
| A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses including all major Omicron strains | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Lu, Y, Gao, Y, Yao, H, Xu, W, Yang, H. | 登録日 | 2023-07-17 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses, including all major Omicron strains. MedComm (2020), 4, 2023
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8K45
| A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses including all major Omicron strains | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nb4 nanobody, ... | 著者 | Lu, Y, Gao, Y, Yao, H, Xu, W, Yang, H. | 登録日 | 2023-07-17 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses, including all major Omicron strains. MedComm (2020), 4, 2023
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8K47
| A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses including all major Omicron strains | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Lu, Y, Gao, Y, Yao, H, Xu, W, Yang, H. | 登録日 | 2023-07-17 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses, including all major Omicron strains. MedComm (2020), 4, 2023
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8KAE
| 16d-bound human SPNS2 | 分子名称: | 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, NbFab chain L, NbFab-H chain, ... | 著者 | He, Y, Duan, Y. | 登録日 | 2023-08-03 | 公開日 | 2024-01-03 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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4GUS
| Crystal structure of LSD2-NPAC with H3 in space group P3221 | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Histone H3.3, ... | 著者 | Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. | 登録日 | 2012-08-29 | 公開日 | 2013-01-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
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3AQS
| Crystal structure of RolR (NCGL1110) without ligand | 分子名称: | Bacterial regulatory proteins, tetR family | 著者 | Li, D.F, Zhang, N, Hou, Y.J, Liu, S.J, Wang, D.C. | 登録日 | 2010-11-18 | 公開日 | 2011-07-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Crystal structures of the transcriptional repressor RolR reveals a novel recognition mechanism between inducer and regulator. Plos One, 6, 2011
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5KSJ
| Crystal structure of deoxygenated hemoglobin in complex with Sphingosine phosphate | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | 著者 | Ahmed, M.H, Safo, M.K, Xia, Y. | 登録日 | 2016-07-08 | 公開日 | 2017-07-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease. Sci Rep, 7, 2017
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5T1I
| CBX3 chromo shadow domain in complex with histone H3 peptide | 分子名称: | Chromobox protein homolog 3, Histone H3.1, UNKNOWN ATOM OR ION | 著者 | Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2016-08-19 | 公開日 | 2016-09-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1. J. Biol. Chem., 292, 2017
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