1X29
 
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3WDZ
 | | Crystal Structure of Keap1 in Complex with phosphorylated p62 | | 分子名称: | Kelch-like ECH-associated protein 1, Peptide from Sequestosome-1 | | 著者 | Fukutomi, T, Takagi, K, Mizushima, T, Tanaka, K, Komatsu, M, Yamamoto, M. | | 登録日 | 2013-06-26 | | 公開日 | 2013-09-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Mol.Cell, 51, 2013
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8IIA
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7WM4
 | | Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RNA (81-MER), ... | | 著者 | Sakaniwa, K, Ohto, U, Shimizu, T. | | 登録日 | 2022-01-14 | | 公開日 | 2023-01-25 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction.
Nat Commun, 14, 2023
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8IJU
 | | ATP-dependent RNA helicase DDX39A (URH49delta41) | | 分子名称: | 1,2-ETHANEDIOL, ATP-dependent RNA helicase DDX39A, PHOSPHATE ION, ... | | 著者 | Mikami, B, Fujita, K, Masuda, S, Kojima, M. | | 登録日 | 2023-02-28 | | 公開日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.
Nat Commun, 15, 2024
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7WIR
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7WRR
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7WRT
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7VTQ
 | | Cryo-EM structure of mouse NLRP3 (full-length) dodecamer | | 分子名称: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ... | | 著者 | Ohto, U, Shimizu, T. | | 登録日 | 2021-10-30 | | 公開日 | 2022-03-09 | | 最終更新日 | 2022-03-23 | | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | | 主引用文献 | Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VTP
 | | Cryo-EM structure of PYD-deleted human NLRP3 hexamer | | 分子名称: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ... | | 著者 | Ohto, U, Shimizu, T. | | 登録日 | 2021-10-30 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7WIS
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2ZFU
 | | Structure of the methyltransferase-like domain of nucleomethylin | | 分子名称: | Cerebral protein 1, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Minami, H, Hashimoto, H, Murayama, A, Yanagisawa, J, Sato, M, Shimizu, T. | | 登録日 | 2008-01-14 | | 公開日 | 2008-12-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Epigenetic control of rDNA loci in response to intracellular energy status
Cell(Cambridge,Mass.), 133, 2008
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5ZQQ
 | | Tankyrase-2 in complex with compound 52 | | 分子名称: | 1-methyl-1'-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl)spiro[indole-3,4'-piperidin]-2(1H)-one, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | | 登録日 | 2018-04-19 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
J. Med. Chem., 62, 2019
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5ZQO
 | | Tankyrase-2 in complex with compound 1a | | 分子名称: | 2-[4-(2-methoxyphenyl)piperazin-1-yl]-5,6,7,8-tetrahydroquinazolin-4(3H)-one, GLYCEROL, SULFATE ION, ... | | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | | 登録日 | 2018-04-19 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
J. Med. Chem., 62, 2019
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5ZQP
 | | Tankyrase-2 in complex with compound 12 | | 分子名称: | 1'-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl)-2H-spiro[1-benzofuran-3,4'-piperidin]-2-one, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | | 登録日 | 2018-04-19 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
J. Med. Chem., 62, 2019
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6IYQ
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7WZ8
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6KGB
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6KZR
 | | Crystal structure of mouse DCAR2 CRD domain | | 分子名称: | C-type lectin domain family 4, member b1, CALCIUM ION, ... | | 著者 | Omahdi, Z, Horikawa, Y, Toyonaga, K, Teramoto, T, Kakuta, Y, Yamasaki, S. | | 登録日 | 2019-09-25 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.304 Å) | | 主引用文献 | Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR.
J.Biol.Chem., 295, 2020
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6LFJ
 | | Crystal structure of mouse DCAR2 CRD domain complex with IPM2 | | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, C-type lectin domain family 4, member b1, ... | | 著者 | Omahdi, Z, Horikawa, Y, Toyonaga, K, Kakuta, Y, Yamasaki, S. | | 登録日 | 2019-12-03 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR.
J.Biol.Chem., 295, 2020
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3B0T
 | | Human VDR ligand binding domain in complex with maxacalcitol | | 分子名称: | (1S,3R,5Z,7E,14beta,17alpha,20S)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol, SULFATE ION, Vitamin D3 receptor | | 著者 | Hishiki, A, Hashimoto, H, Sato, M, Shimizu, T. | | 登録日 | 2011-06-14 | | 公開日 | 2011-08-10 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Human VDR ligand binding domain in complex with maxacalcitol
To be Published
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2LWI
 | | Solution structure of H-RasT35S mutant protein in complex with Kobe2601 | | 分子名称: | 2-(2,4-dinitrophenyl)-N-(4-fluorophenyl)hydrazinecarbothioamide, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Araki, M, Tamura, A, Shima, F, Kataoka, T. | | 登録日 | 2012-08-01 | | 公開日 | 2013-05-22 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
Proc.Natl.Acad.Sci.USA, 110, 2013
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1LLA
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3WC7
 | | Carboxypeptidase B in complex with EF6265 | | 分子名称: | (2S)-7-amino-2-{[(R)-hydroxy{(1R)-2-methyl-1-[(3-phenylpropanoyl)amino]propyl}phosphoryl]methyl}heptanoic acid, Carboxypeptidase B, ZINC ION | | 著者 | Yoshimoto, N, Itoh, T, Inaba, Y, Yamamoto, K. | | 登録日 | 2013-05-24 | | 公開日 | 2013-10-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme.
J.Med.Chem., 56, 2013
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3WAB
 | | Carboxypeptidase B in complex with DD2 | | 分子名称: | (2R)-7-amino-2-(sulfanylmethyl)heptanoic acid, CACODYLATE ION, Carboxypeptidase B, ... | | 著者 | Yoshimoto, N, Itoh, T, Inaba, Y, Yamamoto, K. | | 登録日 | 2013-05-01 | | 公開日 | 2013-10-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.154 Å) | | 主引用文献 | Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme.
J.Med.Chem., 56, 2013
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