8G9B
| Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; compressed filament segment reconstruction | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | 著者 | O'Neill, A.G, Kollman, J.M. | 登録日 | 2023-02-21 | 公開日 | 2023-04-19 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
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8G8F
| Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; extended filament segment reconstruction | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, ... | 著者 | O'Neill, A.G, Kollman, J.M. | 登録日 | 2023-02-17 | 公開日 | 2023-04-19 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
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6CPU
| Crystal structure of yeast caPDE2 | 分子名称: | MAGNESIUM ION, Phosphodiesterase, ZINC ION | 著者 | Ke, H, Wang, y. | 登録日 | 2018-03-14 | 公開日 | 2019-02-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structures of Candida albicans Phosphodiesterase 2 and Implications for Its Biological Functions. Biochemistry, 57, 2018
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5UZT
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5UZZ
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5WXY
| Crystal structure of Microcystis aeruginosa PCC 7806 aspartate racemase in complex with L-aspartate | 分子名称: | ASPARTIC ACID, McyF | 著者 | Cao, D.D, Zhou, K, Jiang, Y.L, Zhou, C.Z. | 登録日 | 2017-01-09 | 公開日 | 2018-01-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Structural insights into the catalysis and substrate specificity of cyanobacterial aspartate racemase McyF. Biochem.Biophys.Res.Commun., 514, 2019
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5WXX
| Crystal structure of Microcystis aeruginosa PCC 7806 aspartate racemase in complex with citrate | 分子名称: | CITRIC ACID, McyF | 著者 | Cao, D.D, Zhou, K, Jiang, Y.L, Zhou, C.Z. | 登録日 | 2017-01-09 | 公開日 | 2018-01-17 | 最終更新日 | 2019-07-31 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural insights into the catalysis and substrate specificity of cyanobacterial aspartate racemase McyF. Biochem.Biophys.Res.Commun., 514, 2019
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3KRJ
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5WXZ
| Crystal structure of Microcystis aeruginosa PCC 7806 aspartate racemase in complex with D-aspartate | 分子名称: | D-ASPARTIC ACID, McyF | 著者 | Cao, D.D, Zhou, K, Jiang, Y.L, Zhou, C.Z. | 登録日 | 2017-01-09 | 公開日 | 2018-01-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural insights into the catalysis and substrate specificity of cyanobacterial aspartate racemase McyF. Biochem.Biophys.Res.Commun., 514, 2019
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5XM8
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7EOD
| MITF HLHLZ Delta AKE | 分子名称: | GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor | 著者 | Li, P, Liu, Z, Fang, P, Wang, J. | 登録日 | 2021-04-22 | 公開日 | 2022-04-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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7F4N
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7F4R
| Crystal structure of MTA1 | 分子名称: | MT-a70 family protein | 著者 | Chen, J, Liu, L. | 登録日 | 2021-06-21 | 公開日 | 2022-06-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Structural basis for MTA1c-mediated DNA N6-adenine methylation Nat Commun, 13, 2022
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7F4P
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7F4S
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7F4O
| Crystal structure of MTA1-p2 complex | 分子名称: | MT-a70 family protein, Transmembrane protein, putative | 著者 | Chen, J, Liu, L. | 登録日 | 2021-06-21 | 公開日 | 2022-06-15 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural basis for MTA1c-mediated DNA N6-adenine methylation Nat Commun, 13, 2022
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7F4Q
| Crystal structure of SAH-bound MTA1-p2 complex | 分子名称: | MT-a70 family protein, S-ADENOSYL-L-HOMOCYSTEINE, Transmembrane protein, ... | 著者 | Chen, J, Liu, L. | 登録日 | 2021-06-21 | 公開日 | 2022-06-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | 主引用文献 | Structural basis for MTA1c-mediated DNA N6-adenine methylation Nat Commun, 13, 2022
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7F4T
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7F4L
| Crystal structure of MTA1-p1-p2 complex | 分子名称: | MT-a70 family protein, Transmembrane protein, putative, ... | 著者 | Chen, J, Liu, L. | 登録日 | 2021-06-21 | 公開日 | 2022-06-15 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Structural basis for MTA1c-mediated DNA N6-adenine methylation Nat Commun, 13, 2022
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7F4M
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3HKS
| Crystal structure of eukaryotic translation initiation factor eIF-5A2 from Arabidopsis thaliana | 分子名称: | 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 5A-2 | 著者 | Teng, Y.B, He, Y.X, Jiang, Y.L, Chen, Y.X, Zhou, C.Z. | 登録日 | 2009-05-25 | 公開日 | 2009-09-29 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of Arabidopsis translation initiation factor eIF-5A2 Proteins, 77, 2009
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6A3N
| Crystal structure of the PDE9 catalytic domain in complex with inhibitor 2 | 分子名称: | 1-cyclopentyl-6-({(2R)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-yl}amino)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | 著者 | Wu, Y.N, Zhou, Q, Chen, Y.P, Luo, H.B. | 登録日 | 2018-06-15 | 公開日 | 2019-04-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. J. Med. Chem., 62, 2019
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6O9D
| Structure of the IRAK4 kinase domain with compound 5 | 分子名称: | Interleukin-1 receptor-associated kinase 4, N-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | 著者 | Yu, C, Drobnick, J, Bryan, M.C, Kiefer, J, Lupardus, P.J. | 登録日 | 2019-03-13 | 公開日 | 2019-05-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J.Med.Chem., 62, 2019
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6O8U
| Crystal structure of IRAK4 in complex with compound 23 | 分子名称: | GLYCEROL, Interleukin-1 receptor-associated kinase 4, N-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ... | 著者 | Kiefer, J.R, Yu, C, Drobnick, J, Bryan, M.C, Lupardus, P.J. | 登録日 | 2019-03-12 | 公開日 | 2019-05-22 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J.Med.Chem., 62, 2019
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6O95
| Structure of the IRAK4 kinase domain with compound 41 | 分子名称: | Interleukin-1 receptor-associated kinase 4, N-[(2R)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, SULFATE ION | 著者 | Yu, C, Drobnick, J, Bryan, M.C, Kiefer, J, Lupardus, P.J. | 登録日 | 2019-03-13 | 公開日 | 2019-05-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J.Med.Chem., 62, 2019
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