1TVB
 
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1TVH
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6L54
 | | Structure of SMG189 | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein SMG8, ... | | 著者 | Xu, Y, Qi, Y. | | 登録日 | 2019-10-22 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | | 主引用文献 | Cryo-EM structure of SMG1-SMG8-SMG9 complex.
Cell Res., 29, 2019
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6L53
 | | Structure of SMG1 | | 分子名称: | Serine/threonine-protein kinase SMG1 | | 著者 | Xu, Y, Qi, Y. | | 登録日 | 2019-10-22 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | | 主引用文献 | Cryo-EM structure of SMG1-SMG8-SMG9 complex.
Cell Res., 29, 2019
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5H14
 | | EED in complex with an allosteric PRC2 inhibitor EED666 | | 分子名称: | 2-[3-(3,5-dimethylpyrazol-1-yl)-4-nitro-phenyl]-3,4-dihydro-1H-isoquinoline, GLYCEROL, Histone-lysine N-methyltransferase EZH2, ... | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | | 登録日 | 2016-10-08 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
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5H25
 | | EED in complex with PRC2 allosteric inhibitor compound 11 | | 分子名称: | 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | | 登録日 | 2016-10-14 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
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5H15
 | | EED in complex with PRC2 allosteric inhibitor EED709 | | 分子名称: | (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | | 登録日 | 2016-10-08 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
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5H24
 | | EED in complex with PRC2 allosteric inhibitor compound 8 | | 分子名称: | 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | | 登録日 | 2016-10-14 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
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5H13
 | | EED in complex with PRC2 allosteric inhibitor EED396 | | 分子名称: | 4-azanylidene-2-(3-methoxy-4-propan-2-yloxy-phenyl)-6,7-dihydro-[1,3]benzodioxolo[6,5-a]quinolizine-3-carbonitrile, GLYCEROL, PRASEODYMIUM ION, ... | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | | 登録日 | 2016-10-08 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
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5H17
 | | EED in complex with PRC2 allosteric inhibitor EED210 | | 分子名称: | (3R,4aS,10aS)-6-methoxy-3-[(3-methoxyphenyl)methyl]-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | | 登録日 | 2016-10-08 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
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7T3B
 | | GATOR1-RAG-RAGULATOR - GAP Complex | | 分子名称: | ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... | | 著者 | Egri, S.B, Shen, K. | | 登録日 | 2021-12-07 | | 公開日 | 2022-04-06 | | 最終更新日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
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7T3A
 | | GATOR1-RAG-RAGULATOR - Inhibitory Complex | | 分子名称: | GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ... | | 著者 | Egri, S.B, Shen, K. | | 登録日 | 2021-12-07 | | 公開日 | 2022-04-06 | | 最終更新日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
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7T3C
 | | GATOR1-RAG-RAGULATOR - Dual Complex | | 分子名称: | ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... | | 著者 | Egri, S.B, Shen, K. | | 登録日 | 2021-12-07 | | 公開日 | 2022-04-06 | | 最終更新日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
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7STF
 | | Structure of KRAS G12V/HLA-A*03:01 in complex with antibody fragment V2 | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A alpha chain, ... | | 著者 | Wright, K.M, Gabelli, S.B, Miller, M. | | 登録日 | 2021-11-12 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen.
Nat Commun, 14, 2023
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8IDE
 | | Structure of an ancient TsaD-TsaC-SUA5-TcdA modular enzyme (TsaN) | | 分子名称: | MANGANESE (II) ION, N(6)-L-threonylcarbamoyladenine synthase | | 著者 | Zhang, Z.L, Jin, M.Q, Yu, Z.J, Chen, W, Wang, X.L, Lei, D.S, Zhang, W.H. | | 登録日 | 2023-02-13 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Structure-function analysis of an ancient TsaD-TsaC-SUA5-TcdA modular enzyme reveals a prototype of tRNA t6A and ct6A synthetases.
Nucleic Acids Res., 51, 2023
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6PEP
 | | Focussed refinement of InvGN0N1:SpaPQR:PrgIJ from the Salmonella SPI-1 injectisome needle complex | | 分子名称: | Protein InvG, Protein PrgH, Protein PrgI, ... | | 著者 | Hu, J, Worrall, L.J, Strynadka, N.C.J. | | 登録日 | 2019-06-20 | | 公開日 | 2019-10-23 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly.
Nat Microbiol, 4, 2019
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6PEE
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6PEM
 | | Focussed refinement of InvGN0N1:SpaPQR:PrgHK from Salmonella SPI-1 injectisome NC-base | | 分子名称: | Lipoprotein PrgK, Protein InvG, Protein PrgH, ... | | 著者 | Hu, J, Worrall, L.J, Strynadka, N.C.J. | | 登録日 | 2019-06-20 | | 公開日 | 2019-10-23 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly.
Nat Microbiol, 4, 2019
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6Q15
 | | Structure of the Salmonella SPI-1 injectisome needle complex | | 分子名称: | Lipoprotein PrgK, Protein InvG, Protein PrgH, ... | | 著者 | Hu, J, Worrall, L.J, Strynadka, N.C.J. | | 登録日 | 2019-08-02 | | 公開日 | 2019-10-23 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (5.15 Å) | | 主引用文献 | T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly.
Nat Microbiol, 4, 2019
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6Q14
 | | Structure of the Salmonella SPI-1 injectisome NC-base | | 分子名称: | Lipoprotein PrgK, Protein InvG, Protein PrgH, ... | | 著者 | Hu, J, Worrall, L.J, Strynadka, N.C.J. | | 登録日 | 2019-08-02 | | 公開日 | 2019-10-23 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly.
Nat Microbiol, 4, 2019
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6QDB
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6QDA
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6QDG
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7ROZ
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7RQS
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