6JCR
 
 | | AAV1 in neutral condition at 3.07 Ang | | 分子名称: | Capsid protein | | 著者 | Lou, Z, Zhang, R. | | 登録日 | 2019-01-30 | | 公開日 | 2019-10-23 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Divergent engagements between adeno-associated viruses with their cellular receptor AAVR.
Nat Commun, 10, 2019
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6JCQ
 | | AAV1 in complex with AAVR | | 分子名称: | Capsid protein, Dyslexia-associated protein KIAA0319-like protein | | 著者 | Lou, Z, Zhang, R. | | 登録日 | 2019-01-30 | | 公開日 | 2019-10-23 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Divergent engagements between adeno-associated viruses with their cellular receptor AAVR.
Nat Commun, 10, 2019
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8JAH
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6JCT
 | | AAV5 in neutral condition at 3.18 Ang | | 分子名称: | Capsid protein | | 著者 | Lou, Z, Zhang, R. | | 登録日 | 2019-01-30 | | 公開日 | 2019-07-31 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Divergent engagements between adeno-associated viruses with their cellular receptor AAVR.
Nat Commun, 10, 2019
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7WED
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7WEA
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7WE8
 | | SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv265 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 265, ... | | 著者 | Wang, X, Wang, L. | | 登録日 | 2021-12-23 | | 公開日 | 2022-05-04 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants.
Nature, 603, 2022
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7WE7
 | | SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv282 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 282, ... | | 著者 | Wang, X, Wang, L. | | 登録日 | 2021-12-23 | | 公開日 | 2022-05-04 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants.
Nature, 603, 2022
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7WEE
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7WEB
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7WEF
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7WEC
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7WE9
 | | SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv289 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Wang, X, Wang, L. | | 登録日 | 2021-12-23 | | 公開日 | 2022-05-04 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants.
Nature, 603, 2022
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7WLC
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8Y58
 | | Crystal structure of TRIM21 PRYSPRY (D355A) in complex with acepromazine. | | 分子名称: | 1-[10-(3-DIMETHYLAMINO-PROPYL)-10H-PHENOTHIAZIN-2-YL]-ETHANONE, E3 ubiquitin-protein ligase TRIM21, FORMIC ACID | | 著者 | Lu, P, Cheng, Y, Xue, L, Ren, X, Huang, N, Han, T. | | 登録日 | 2024-01-31 | | 公開日 | 2024-10-09 | | 最終更新日 | 2024-12-25 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders.
Cell, 187, 2024
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8Y59
 | | Crystal structure of TRIM21 PRYSPRY (D355A) in complex with (S)-hydroxyl-acepromazine. | | 分子名称: | (1~{S})-1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanol, E3 ubiquitin-protein ligase TRIM21 | | 著者 | Lu, P, Cheng, Y, Xue, L, Ren, X, Huang, N, Han, T. | | 登録日 | 2024-01-31 | | 公開日 | 2024-10-09 | | 最終更新日 | 2024-12-25 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders.
Cell, 187, 2024
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8Y5B
 | | Crystal structure of TRIM21 PRYSPRY (D355A) in complex with (R)-hydroxyl-acepromazine. | | 分子名称: | (1~{R})-1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanol, E3 ubiquitin-protein ligase TRIM21 | | 著者 | Lu, P, Cheng, Y, Xue, L, Ren, X, Huang, N, Han, T. | | 登録日 | 2024-01-31 | | 公開日 | 2024-10-09 | | 最終更新日 | 2024-12-25 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders.
Cell, 187, 2024
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7UHC
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7WQV
 | | Crystal structure of a neutralizing monoclonal antibody (Ab08) in complex with SARS-CoV-2 receptor-binding domain (RBD) | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Ab08, ... | | 著者 | Zha, J, Meng, L, Zhang, X, Li, D. | | 登録日 | 2022-01-26 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy.
Plos Pathog., 19, 2023
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8HEF
 | | The Crystal structure of deuterated S-217622 (Ensitrelvir) bound to the main protease (3CLpro/Mpro) of SARS-CoV-2 | | 分子名称: | 3C-like proteinase, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, GLYCEROL | | 著者 | Yan, M, Zhang, H. | | 登録日 | 2022-11-08 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2.
Antiviral Res., 213, 2023
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7XCT
 | | Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex | | 分子名称: | DNA (145-MER), Histone H2A, Histone H2B type 1-K, ... | | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | | 登録日 | 2022-03-25 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.
Nat.Chem.Biol., 18, 2022
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7XCR
 | | Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 1:1 complex | | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B type 1-K, ... | | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | | 登録日 | 2022-03-25 | | 公開日 | 2022-04-20 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.
Nat.Chem.Biol., 18, 2022
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7XD0
 | | cryo-EM structure of H2BK34ub nucleosome | | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B type 1-K, ... | | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | | 登録日 | 2022-03-26 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.
Nat.Chem.Biol., 18, 2022
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7XD1
 | | cryo-EM structure of unmodified nucleosome | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | | 登録日 | 2022-03-26 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.
Nat.Chem.Biol., 18, 2022
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8ZBQ
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