8Y58

Crystal structure of TRIM21 PRYSPRY (D355A) in complex with acepromazine.

Summary for 8Y58

Entry DOI	10.2210/pdb8y58/pdb
Related	8Y59 8Y5B
Descriptor	E3 ubiquitin-protein ligase TRIM21, 1-[10-(3-DIMETHYLAMINO-PROPYL)-10H-PHENOTHIAZIN-2-YL]-ETHANONE, FORMIC ACID, ... (4 entities in total)
Functional Keywords	trim21, pryspry, acepromazine, ligase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	22061.76
Authors	Lu, P.,Cheng, Y.,Xue, L.,Ren, X.,Huang, N.,Han, T. (deposition date: 2024-01-31, release date: 2024-10-09)
Primary citation	Lu, P.,Cheng, Y.,Xue, L.,Ren, X.,Chen, C.,Li, J.,Wu, Q.,Sun, S.,Hou, J.,Jia, W.,Li, C.,Qi, X.,Huang, N.,Han, T. Selective degradation of multimeric proteins via chemically induced proximity to TRIM21. To be published,
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation