7WX4
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7WXH
| GPR domain open form of Drosophila P5CS filament with glutamate, ATP, and NADPH | 分子名称: | Delta-1-pyrroline-5-carboxylate synthase | 著者 | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | 登録日 | 2022-02-14 | 公開日 | 2022-03-30 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7WXG
| GPR domain closed form of Drosophila P5CS filament with glutamate, ATP, and NADPH | 分子名称: | Delta-1-pyrroline-5-carboxylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | 登録日 | 2022-02-14 | 公開日 | 2022-03-30 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7WXF
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7WX3
| GK domain of Drosophila P5CS filament with glutamate, ATP, and NADPH | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Delta-1-pyrroline-5-carboxylate synthase, GAMMA-GLUTAMYL PHOSPHATE, ... | 著者 | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | 登録日 | 2022-02-14 | 公開日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7WD4
| Crystal structure of the Ilheus virus helicase: implications for enzyme function and drug design | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, NS3 helicase | 著者 | Wang, D.P, Wang, M.Y, Zhou, X, Wang, W.M, Cao, J.M. | 登録日 | 2021-12-21 | 公開日 | 2023-01-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structure of the Ilheus virus helicase: implications for enzyme function and drug design To Be Published
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7C72
| Structure of a mycobacterium tuberculosis puromycin-hydrolyzing peptidase | 分子名称: | D-MALATE, GLYCEROL, Prolyl oligopeptidase | 著者 | Ruiz-Carrillo, D, Zhao, Y.H, Feng, Q, Zhou, X, Zhang, Y, Jiang, J, Lukman, M. | 登録日 | 2020-05-22 | 公開日 | 2021-03-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.00004458 Å) | 主引用文献 | Mycobacterium tuberculosis puromycin hydrolase displays a prolyl oligopeptidase fold and an acyl aminopeptidase activity. Proteins, 89, 2021
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7DJ1
| Crystal structure of the G26C mutant of LeuT | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | 登録日 | 2020-11-19 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.528 Å) | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
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7DII
| Crystal structure of LeuT in lipidic cubic phase at pH 7 | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | 登録日 | 2020-11-19 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.403 Å) | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
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7DIX
| Crystal structure of LeuT in lipidic cubic phase at pH 5 | 分子名称: | Na(+):neurotransmitter symporter (Snf family), SELENOMETHIONINE, SODIUM ION | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | 登録日 | 2020-11-19 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
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7DJ2
| Crystal structure of the G26C/E290S mutant of LeuT | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | 登録日 | 2020-11-19 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
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7DJC
| Crystal structure of the G26C/Q250A mutant of LeuT | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | 登録日 | 2020-11-20 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
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6D39
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6D38
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8K4F
| DHODH in complex with compound A0 | 分子名称: | 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine, 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, ACETATE ION, ... | 著者 | Jian, L, Sun, Q. | 登録日 | 2023-07-18 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Discovery and Optimization of Novel h DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease. J.Med.Chem., 66, 2023
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8I5M
| Rat Kir4.1 in complex with PIP2 | 分子名称: | ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Zhao, C, Guo, J. | 登録日 | 2023-01-26 | 公開日 | 2024-02-28 | 最終更新日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses. Nat.Chem.Biol., 20, 2024
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8I5N
| Rat Kir4.1 in complex with PIP2 and Lys05 | 分子名称: | ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Zhao, C, Guo, J. | 登録日 | 2023-01-26 | 公開日 | 2024-02-28 | 最終更新日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses. Nat.Chem.Biol., 20, 2024
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7MF1
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 47D1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 47D1 Fab heavy chain, ... | 著者 | Yuan, M, Zhu, X, Wilson, I.A. | 登録日 | 2021-04-08 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | 主引用文献 | Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2. Cell Rep, 35, 2021
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7C2Q
| The crystal structure of COVID-19 main protease in the apo state | 分子名称: | 3C-like proteinase | 著者 | Zhou, X.L, Zhong, F.L, Lin, C, Hu, X.H, Zhou, H, Wang, Q.S, Li, j, Zhang, J. | 登録日 | 2020-05-08 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structure of SARS-CoV-2 main protease in the apo state. Sci China Life Sci, 64, 2021
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8HCO
| Substrate-engaged TOM complex from yeast | 分子名称: | Mitochondrial import receptor subunit TOM22, Mitochondrial import receptor subunit TOM40, Mitochondrial import receptor subunit TOM5, ... | 著者 | Zhou, X.Y, Yang, Y.Q, Wang, G.P, Wang, S.S. | 登録日 | 2022-11-02 | 公開日 | 2023-09-13 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Molecular pathway of mitochondrial preprotein import through the TOM-TIM23 supercomplex. Nat.Struct.Mol.Biol., 30, 2023
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6L6Z
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6LFG
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8SMK
| hPAD4 bound to Activating Fab hA362 | 分子名称: | Activating Fab 362 heavy chain, Activating Fab 362 light chain, CALCIUM ION, ... | 著者 | Maker, A, Verba, K.A. | 登録日 | 2023-04-26 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4. Nat.Chem.Biol., 20, 2024
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8SML
| hPAD4 bound to inhibitory Fab hI365 | 分子名称: | CALCIUM ION, Fab hI365 heavy chain, Fab hI365 light chain, ... | 著者 | Maker, A, Verba, K.A. | 登録日 | 2023-04-26 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4. Nat.Chem.Biol., 20, 2024
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7WIZ
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